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ENZYME

ENZYME entry: EC 1.14.15.4

Accepted Name
steroid 11beta-monooxygenase
Alternative Name(s)
cytochrome p450 XIB1
steroid 11beta/18-hydroxylase
steroid 11beta-hydroxylase
Reaction catalysed
a steroid + 2 H(+) + O2 + 2 reduced [adrenodoxin] <=> an 11beta-hydroxysteroid + H2O + 2 oxidized [adrenodoxin]
Comment(s)
  • Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone.
  • Formerly EC 1.14.1.6 and EC 1.99.1.7.
Cross-references
BRENDA1.14.15.4
EC2PDB1.14.15.4
ExplorEnz1.14.15.4
PRIAM enzyme-specific profiles1.14.15.4
KEGG Ligand Database for Enzyme Nomenclature1.14.15.4
IUBMB Enzyme Nomenclature1.14.15.4
IntEnz1.14.15.4
MEDLINEFind literature relating to 1.14.15.4
MetaCyc1.14.15.4
Rhea expert-curated reactions1.14.15.4
UniProtKB/Swiss-Prot
P15150, C11B1_BOVINQ64408, C11B1_CAVPOP15538, C11B1_HUMAN
P97720, C11B1_MESAUQ29527, C11B1_PAPHUQ29552, C11B1_PIG
P15393, C11B1_RATP51663, C11B1_SHEEPP19099, C11B2_HUMAN
Q64658, C11B2_MESAUP15539, C11B2_MOUSEP30099, C11B2_RAT
P30100, C11B3_RATQ92104, CP11B_AQUCT

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