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ENZYME

ENZYME entry: EC 1.8.1.12

Accepted Name
trypanothione-disulfide reductase
Alternative Name(s)
N(1),N(8)-bis(glutathionyl)spermidine reductase
NADPH:trypanothione oxidoreductase
trypanothione reductase
Reaction catalysed
NADP(+) + trypanothione <=> H(+) + NADPH + trypanothione disulfide
Comment(s)
  • Trypanothione disulfide is the oxidized form of N(1),N(8)- bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata.
  • The activity is dependent on a redox-active cystine at the active center (cf. EC 1.8.1.7).
  • Formerly EC 1.6.4.8.
Cross-references
BRENDA1.8.1.12
EC2PDB1.8.1.12
ExplorEnz1.8.1.12
PRIAM enzyme-specific profiles1.8.1.12
KEGG Ligand Database for Enzyme Nomenclature1.8.1.12
IUBMB Enzyme Nomenclature1.8.1.12
IntEnz1.8.1.12
MEDLINEFind literature relating to 1.8.1.12
MetaCyc1.8.1.12
Rhea expert-curated reactions1.8.1.12
UniProtKB/Swiss-Prot
P39040, TYTR_CRIFAP39050, TYTR_LEIDOP39051, TYTR_TRYBB
P13110, TYTR_TRYCOP28593, TYTR_TRYCR

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