ProtParam

SYNE1_HUMAN (Q8NF91)

Nesprin-1 (Enaptin) (KASH domain-containing protein 1) (KASH1) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1)
Homo sapiens (Human)

The computation has been carried out on the complete sequence (8797 amino acids).

Warning: All computation results shown below do not take into account
any annotated post-translational modification.
 References and documentation are available.

Number of amino acids: 8797

Molecular weight: 1011085.96

Theoretical pI: 5.37

Amino acid composition: 
Ala (A) 569	  6.5%
Arg (R) 425	  4.8%
Asn (N) 289	  3.3%
Asp (D) 465	  5.3%
Cys (C) 117	  1.3%
Gln (Q) 763	  8.7%
Glu (E) 972	 11.0%
Gly (G) 291	  3.3%
His (H) 238	  2.7%
Ile (I) 391	  4.4%
Leu (L)1148	 13.0%
Lys (K) 697	  7.9%
Met (M) 204	  2.3%
Phe (F) 206	  2.3%
Pro (P) 176	  2.0%
Ser (S) 730	  8.3%
Thr (T) 413	  4.7%
Trp (W) 131	  1.5%
Tyr (Y) 142	  1.6%
Val (V) 430	  4.9%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 1437
Total number of positively charged residues (Arg + Lys): 1122

Atomic composition:

Carbon      C	     44190
Hydrogen    H	     71252
Nitrogen    N	     12428
Oxygen      O	     14009
Sulfur      S	       321

Formula: C44190H71252N12428O14009S321
Total number of atoms: 142200

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   939330
Abs 0.1% (=1 g/l)   0.929, assuming all pairs of Cys residues form cystines


Ext. coefficient   932080
Abs 0.1% (=1 g/l)   0.922, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 51.64
This classifies the protein as unstable.



Aliphatic index: 88.87

Grand average of hydropathicity (GRAVY): -0.622