ProtParam

User-provided sequence:

        10         20         30         40         50         60 
SDLEKTQNRT QRRMPKELSA TRKKDQISGY TVQTHSVEET RPIEEPNSIA TPQETPVNES 

        70         80         90        100        110        120 
MITGWSTTRK IQKPVFNKPL SELKIRKTDP MQRESSVDMI SSSVSRKKRG SDTERIKQLL 

       130        140        150        160        170        180 
ENKTDKMSHE SLSSNNRKLL ITKDIKPDNN QYKKESSIST YYPKKIKCKF DDKHGRPCII 

       190        200        210        220        230        240 
CWKINNLFIE NNEGSAASLL KFIFAPTVVP ISHFKKIYEI KRKMSNRLIS NNQFDKRNND 

       250        260        270        280        290        300 
GPDDNNNNIC FQTFLDSFEN SWLPHTKPIS PLAALNILLI DTSKNLYEVY NIGMPKLLNL 

       310        320        330        340        350        360 
VKTLHLLEVG SFGTITVNLF PSSSFEHHLL KSSSSVQFEI TSLFPKSWLD IPHLLKQYYL 

       370        380        390        400        410        420 
CREIFFETVI GDNDDIIEPL DNFSDLAKNS PIIYYSHDYI GSLYSTEIKG GNQVVIKTLI 

       430        440        450        460        470        480 
SRHNGPFIHH IIFACNKFIL TSNDSLDEQK NNISLPSQGL VSFNTKSHQQ LSMAKDWIKE 

       490        500        510        520        530        540 
GKPKFKNLLS STKPLSPTLT SSSQQRQLSS QADINTPFTT NIKDWCDCSN SGISDYPLDK 

       550        560        570        580        590        600 
INPLLYYPDY PLLASRKQCD LIWKFHVIPI NQEIAANVRA GLLTDTVFIS IQGNQGQDDD 

       610        620        630        640        650        660 
DNHSSTDKIV FNQYNYSSCG LKKISRVLSD ISTINTDTIR GIFINFNHLY KFSFRRYLIK 

       670        680        690        700        710        720 
LMEYTSGTMT ATNSDPLINE GSLWLQYIDD IAQIDIFIID FRHKVAFKFK NTNTTSGVVL 

       730        740        750        760 
VNVQRTLDKS FIGGLKIIKK SIKKALIENN IATPCFTIGQ FPKM 

References and documentation are available.

Number of amino acids: 764

Molecular weight: 87240.64

Theoretical pI: 9.08

Amino acid composition: 
Ala (A)  20	  2.6%
Arg (R)  27	  3.5%
Asn (N)  59	  7.7%
Asp (D)  47	  6.2%
Cys (C)  11	  1.4%
Gln (Q)  32	  4.2%
Glu (E)  32	  4.2%
Gly (G)  28	  3.7%
His (H)  18	  2.4%
Ile (I)  77	 10.1%
Leu (L)  68	  8.9%
Lys (K)  69	  9.0%
Met (M)  11	  1.4%
Phe (F)  38	  5.0%
Pro (P)  37	  4.8%
Ser (S)  81	 10.6%
Thr (T)  51	  6.7%
Trp (W)   8	  1.0%
Tyr (Y)  23	  3.0%
Val (V)  27	  3.5%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 79
Total number of positively charged residues (Arg + Lys): 96

Atomic composition:

Carbon      C	      3906
Hydrogen    H	      6175
Nitrogen    N	      1049
Oxygen      O	      1169
Sulfur      S	        22

Formula: C3906H6175N1049O1169S22
Total number of atoms: 12321

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    78895
Abs 0.1% (=1 g/l)   0.904, assuming all pairs of Cys residues form cystines


Ext. coefficient    78270
Abs 0.1% (=1 g/l)   0.897, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is S (Ser).

The estimated half-life is: 1.9 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 36.65
This classifies the protein as stable.



Aliphatic index: 86.88

Grand average of hydropathicity (GRAVY): -0.448