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ProtParam

User-provided sequence:

        10         20         30         40         50         60 
LLFNIALVVK FELLLIAFRS HFRFRFTFVQ AMVLPPLAKW PYENGFTFTT WCRLDPINSV 

        70         80         90        100        110        120 
NIEREKPYLY SFKTSKGVGY TAHFVGNCLV LTSMKVKGKG FQHCVKYEFQ PRKWYMIAIV 

       130        140        150        160        170        180 
YIYNRWTKSE IKCLVNGQLA SSTEMAWFVS TNDPFDKCYI GATPELDEER VFCGQMSAIY 

       190        200        210        220        230        240 
LFSEALTTQQ ICAMHRLGPG YKSQFRFDNE CYLNLPDNHK RVSHFQLLPA TLGASALSGG 

       250        260        270        280        290        300 
SGSGAGSGSG NDASAAAAAA VAAGQQQQLQ LQFQILAAEQ EARAIDWSDE KLDLNAAFVK 

       310        320        330        340        350        360 
IRAVLTARNA VTLAGSSSTG TTAVATAAAA AAAAGAGAGT TAAATSAAAA AAATQNENDA 

       370        380        390        400        410        420 
AVGQQQHATH HHATAATGSA DDPLGDLPTG NASSSSSSFE QLRRMSSVSS LNSMVGSADT 

       430        440        450        460        470        480 
EEVDQLKAVL YDGKLSNAIV FMYNPVATDG QLCLQSSPKG NVSYFVHTPH ALMLQDVKAV 

       490        500        510        520        530        540 
VTHSIHCTLN SIGGIQVLFP LFSQLDMAHE GLGDIKRDPT LCSKLLGFIC ELVETSQTVQ 

       550        560        570        580        590        600 
QHMIQNRGFL VISFMLQRSS REHLTLEVLG SFLNLTKYLV TCLSANSDLL LKQLLDHVLF 

       610        620        630        640        650        660 
NPALWIYTPA NVQARLYSYL ATEFLSDTQI YSNVRRVSTV LQTVHTLKYY YWVVNPRAKS 

       670        680        690        700        710        720 
GIIPKGLDGP RPAQKDILAI RAYILLFLKQ LIMIGNGVKE DELQSILNYL TTMHEDENLH 

       730        740        750        760        770        780 
DVLQMLISLM SEHPSSMVPA FDVKHGVRSI FKLLAAESQL IRLQALKLLG FFLSRSTHKR 

       790        800        810        820        830        840 
KYDVMSPHNL YTLLAERLLL YEESLSLPTY NVLYEIMTEH ISQQILYTRH PEPESHYRLE 

       850        860        870        880        890        900 
NPMILKVVAT LIRQSKQTES LIDVKKLFLQ DMTLLCNSNR ENRRTVLQMS VWQEWLIAMA 

       910        920        930        940        950        960 
YIHPKSSEEQ KISDMVYSLF RMLLHHAIKH EYGGWRVWVD TLAIVHSKVS YEEFKLQFAQ 

       970        980        990       1000       1010       1020 
MYEHYERQRT DNITDPALRQ ARPISTISGW EREELHQQQN GGSAAAVATN QTAAVKGSVS 

      1030       1040       1050       1060       1070       1080 
IASLEDVPPV VEEEVEELEL EEVEIQEGPI TEETEQKSVI ANISDVYNEQ LKTDATCNGN 

      1090       1100       1110       1120       1130       1140 
LEDVKEEEPV QQQIGDLEKQ PEPSTPLGAL RETLQLGDDM DVEELELATA KDALNAEQHV 

      1150       1160       1170       1180       1190       1200 
SRVLQASEAA LNDCKMAVDD VLQESSSVLK DEEIELAVNE VVQGVLNNEK KTQSQDNKDN 

      1210       1220       1230       1240       1250       1260 
KEQPGEQDVN VSLLNSKNLL NNNNNNNNNS PSPTPTTATA TAETEAETEV NANEIVSSTE 

      1270       1280       1290       1300       1310       1320 
APKAETETSV APEVETPETA KPSPIVPSPV LATNQKTEDA ANKLNNNEKL AEISASPEPP 

      1330       1340       1350       1360       1370       1380 
IVVETPEADL LQLSDSETKP NKETEAEDSV ALAVRDIVEQ LIDKVIDATE AESASETKTE 

      1390       1400       1410       1420       1430       1440 
TNNNEIPKKE KQTSEEPEDV ETAETLAAAA KEIVQEVVEA ALVMVQEEST QEKPEKGANS 

      1450       1460       1470       1480       1490       1500 
EEEKNEIGKE EILLQLEEKP ASTEVQETKI EGDLKKPEDP KGHSSVEPKT PNLEEPKPQE 

      1510       1520       1530       1540       1550       1560 
TEQQKSQEVA EELPQKPEEQ VVAIVTQVLD TLVDDTVKAV AAEQTTQTSP APEEQSPQIL 

      1570       1580       1590       1600       1610       1620 
AMESPATSVR VKPTEVDSTT QTTPKNEAGS SLLVEQVQQV LQEDDAQQSA GMTIEDEDYS 

      1630       1640       1650       1660       1670       1680 
NQQAAAAVEN ANSSQLDANH YGPGNPESKQ QQQRSKSGST RPMFSPGPTR PPFRIPEFKW 

      1690       1700       1710       1720       1730       1740 
SYIHQRLLSD VLFSLETDIQ VWRSHSTKSV LDFVNSSENA IFVVNTVHLI SQLADNLIIA 

      1750       1760       1770       1780       1790       1800 
CGGLLPLLAS ATSPNSELDV LEPTQGMPLE VAVSFLQRLV NMADVLIFAT SLNFGELEAE 

      1810       1820       1830       1840       1850       1860 
KNMSSGGILR QCLRLVCTCA VRNCLECKER TRYNVGALAR DVPGAAHLQA LIRGAQASPK 

      1870       1880       1890       1900       1910       1920 
NIVESITGQL SPVKDPEKLL QDMDVNRLRA VIYRDVEETK QAQFLSLAIV YFISVLMVSK 

      1930       1940       1950       1960       1970       1980 
YRDILEPPAE PQIQRQSPVL QRTAGGEAAS ARPLFPQWSH HVYPQFLPES HQNHNSNMQH 

      1990       2000       2010       2020       2030       2040 
QQQQQQQQQQ QQQQHYYQQQ QQQQVVHNHS HHHMTAAYYQ QQQHQQVAAG QQQHSPTPLA 

      2050       2060       2070       2080       2090       2100 
THSTSSSASS TATSQPASSS SLSSLASQSQ QQSHRQLHKQ QQQQQQQQQQ QQPHYHPHQP 

      2110       2120       2130       2140       2150       2160 
HYGLINGHQQ HPQLNGKHYA ENGSTAGYHP HSHPHPHGGY MRNGDTSTLQ QNGMPDYQAV 

      2170       2180       2190       2200       2210       2220 
GLMNGHGSGG TGNNNNSSLM NNMRNLRNGG GANSSSSPPG SHQVIQGVAT AGAVNANAAV 

      2230       2240       2250       2260       2270       2280 
GVGMGGAVGV GMGGVAGGLD GGVVYKTSAI NNNYRYNGRN ASAGTGGRQI QDSDYEIIVV 

      2290       2300       2310       2320       2330       2340 
DENNPSVLAD NDSHSSGPPS IKSVDSDVGS LNMNSTGKTK CPRWSHPSEI LIDDHKPSHS 

      2350       2360       2370       2380       2390       2400 
NDESWTDVNL NEDAAVQAAS AGIVVGLVDN RGNVISDKHD PSHHNQQQQQ QAGIIGQQQQ 

      2410       2420       2430       2440       2450       2460 
HGSLGHSERG DKPDSEISVV RVPDGYGGAG SGGGVNSGQG QGVPSNQRPR PEELPMKAPA 

      2470       2480       2490       2500       2510       2520 
LVAQLPLTTP SREASLTQKL EIALGPVCPL LREIMVDFAP FLSKTLVGSH GQELLMEGKG 

      2530       2540       2550       2560       2570       2580 
LTTFKNSHSV VELVMLLCSQ EWQNSLQKHA GLAFIELINE GRLLSHAMKD HIVRVANEAE 

      2590       2600       2610       2620       2630       2640 
FILNRMRADD VLKHADFESQ CAQTLLERRE EERMCDHLIT AARRRDNVIA SRLLEKVRNI 

      2650       2660       2670       2680       2690       2700 
MCNRHGAWGD SSSTSSGGAI VGAGQKSPYW KLDAWEDDAR RRKRMVQNPR GSSHPQATLK 

      2710       2720       2730       2740       2750       2760 
AALENGGPED AILQTRDEFH TQIAVSRTHP SGQHNGELLD DAELLIEDRE LDLDLTGPVN 

      2770       2780       2790       2800       2810       2820 
ISTKARLIAP GLVAPGTVSI TSTEMFFEVD EEHPEFQKID GEVLKYCDHL HGKWYFSEVR 

      2830       2840       2850       2860       2870       2880 
AIFSRRYLLQ NVALEIFLAS RTSILFAFPD QHTVKKVIKA LPRVGVGIKY GIPQTRRASM 

      2890       2900       2910       2920       2930       2940 
MSPRQLMRNS NMTQKWQRRE ISNFEYLMFL NTIAGRTYND LNQYPIFPWV LTNYESKDLD 

      2950       2960       2970       2980       2990       3000 
LSLPSNYRDL SKPIGALNPS RRAYFEERYE SWDSDTIPPF HYGTHYSTAA FTLNWLVRVE 

      3010       3020       3030       3040       3050       3060 
PFTTMFLALQ GGKFDYPDRL FSSVSLSWKN CQRDTSDVKE LIPEWYFLPE MFYNSSGYRL 

      3070       3080       3090       3100       3110       3120 
GHREDGALVD DIELPPWAKS PEEFVRINRM ALESEFVSCQ LHQWIDLIFG YKQRGPEAIR 

      3130       3140       3150       3160       3170       3180 
ATNVFYYLTY EGSVDLDGVL DPVMREAVEN QIRNFGQTPS QLLMEPHPPR SSAMHLSPMM 

      3190       3200       3210       3220       3230       3240 
FSAMPEDLCQ MLKFYQNSPV IHISANTYPQ LSLPSVVTVT AGHQFAVNRW NCNYTASVQS 

      3250       3260       3270       3280       3290       3300 
PSYAESPQSP GSNQPLTIDP VLAVHGTNNN SNAASRRHLG DNFSQMLKIR SNCFVTTVDS 

      3310       3320       3330       3340       3350       3360 
RFLIACGFWD NSFRVFATET AKIVQIVFGH FGVVTCMARS ECNITSDCYI ASGSADCTVL 

      3370       3380       3390       3400       3410       3420 
LWHWNARTQS IVGEGDVPTP RATLTGHEQA VTSVVISAEL GLVVSGSSNG PVLIHTTFGD 

      3430       3440       3450       3460       3470       3480 
LLRSLDPPAE FHSPELITMS REGFIVINYD KGNVAAYTIN GKKLRHETHN DNLQCMLLSR 

      3490       3500       3510       3520       3530       3540 
DGEYLMTAGD RGIVEVWRTF NLAPLYAFPA CNAGIRSLAL THDQKYLLAG LSTGSIIVFH 

      3550 
IDFNRWHHEY QQRY


References and documentation are available. 

Number of amino acids: 3554

Molecular weight: 393341.39

Theoretical pI: 5.42


Amino acid composition: 
Ala (A) 296	  8.3%
Arg (R) 152	  4.3%
Asn (N) 188	  5.3%
Asp (D) 161	  4.5%
Cys (C)  41	  1.2%
Gln (Q) 248	  7.0%
Glu (E) 258	  7.3%
Gly (G) 204	  5.7%
His (H) 118	  3.3%
Ile (I) 158	  4.4%
Leu (L) 332	  9.3%
Lys (K) 143	  4.0%
Met (M)  78	  2.2%
Phe (F) 105	  3.0%
Pro (P) 182	  5.1%
Ser (S) 308	  8.7%
Thr (T) 203	  5.7%
Trp (W)  37	  1.0%
Tyr (Y)  96	  2.7%
Val (V) 246	  6.9%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%



Total number of negatively charged residues (Asp + Glu): 419
Total number of positively charged residues (Arg + Lys): 295

Atomic composition:

Carbon      C	     17245
Hydrogen    H	     27108
Nitrogen    N	      4862
Oxygen      O	      5436
Sulfur      S	       119

Formula: C17245H27108N4862O5436S119
Total number of atoms: 54770

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   349040
Abs 0.1% (=1 g/l)   0.887, assuming all pairs of Cys residues form cystines


Ext. coefficient   346540
Abs 0.1% (=1 g/l)   0.881, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is L (Leu).

The estimated half-life is: 5.5 hours (mammalian reticulocytes, in vitro).
                            3 min (yeast, in vivo).
                            2 min (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 50.61
This classifies the protein as unstable.



Aliphatic index: 82.17

Grand average of hydropathicity (GRAVY): -0.407