ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MAAPEDVAAL QDEIARREEE LASLKQRLAA ALAVEPEPER PIPVMPLPSR AALSRDEILR 

        70         80         90        100        110        120 
YSRQLLLPEL GVRGQLRLAA ASVLVVGCGG LGCPLAQYLA AAGVGRLGLV DHDVVETSNL 

       130        140        150        160        170        180 
ARQVLHGEAQ AGHAKAWSAA AALRRLNSAV EYVPYARALS EAWALDLVRG YDVVADCSDN 

       190        200        210        220        230        240 
VPTRYLVNDA CVLAGRPLVS ASALRFEGQM TVYHYDDGPC YRCVFPRPPP AETVTNCADG 

       250        260        270        280        290        300 
GVLGVVPGVL GCVQALEVLK IAAGLGTTYS GSMLLFDGLG GHFRRIRLRR RRPDCVVCGQ 

       310        320        330        340        350        360 
QPTVTCLKNY EAFCGSSATD KCRSLKLLSP EERISVTDYK RLLDSGVPHV LLDVRPQVEV 

       370        380        390        400        410        420 
DICRLQHSLH IPLSLLERRD ADSLKLLGAA LQEEKRNSQE GAALAVYVIC KLGNDSQKAV 

       430        440        450 
RVLQSLTAVP ELDSLKVQDI SGGLMAWAAK IDGTFPQY 

References and documentation are available.

Number of amino acids: 458

Molecular weight: 49388.91

Theoretical pI: 6.47

Amino acid composition: 
Ala (A)  56	 12.2%
Arg (R)  37	  8.1%
Asn (N)   8	  1.7%
Asp (D)  26	  5.7%
Cys (C)  15	  3.3%
Gln (Q)  19	  4.1%
Glu (E)  26	  5.7%
Gly (G)  35	  7.6%
His (H)   8	  1.7%
Ile (I)  11	  2.4%
Leu (L)  64	 14.0%
Lys (K)  13	  2.8%
Met (M)   5	  1.1%
Phe (F)   6	  1.3%
Pro (P)  26	  5.7%
Ser (S)  28	  6.1%
Thr (T)  13	  2.8%
Trp (W)   3	  0.7%
Tyr (Y)  14	  3.1%
Val (V)  45	  9.8%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 52
Total number of positively charged residues (Arg + Lys): 50

Atomic composition:

Carbon      C	      2171
Hydrogen    H	      3528
Nitrogen    N	       628
Oxygen      O	       645
Sulfur      S	        20

Formula: C2171H3528N628O645S20
Total number of atoms: 6992

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    38235
Abs 0.1% (=1 g/l)   0.774, assuming all pairs of Cys residues form cystines


Ext. coefficient    37360
Abs 0.1% (=1 g/l)   0.756, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 51.43
This classifies the protein as unstable.



Aliphatic index: 104.59

Grand average of hydropathicity (GRAVY): 0.041