ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MAAVTWSRAR CWCPSLLQVL RLPVTKLHLG RPAMRATQQD FENAMNQVKL LKKDPGNEVK 

        70         80         90        100        110        120 
LRLYALYKQA TEGPCTMPKP GVFDFVNKAK WDAWNALGSL PKETARQNYV DLVSSLSSSS 

       130        140        150        160        170        180 
EASSQGKGGA DGKAQESKGI LVTSEGGITK ITFNRPSKKN AITFQMYQDI ILALKNASTD 

       190        200        210        220        230        240 
DTVITVFTGA GDYYSSGNDL TNFTSASGGM EEAANKGAIV LREFVNTFID FPKPLVAVVN 

       250        260        270        280        290        300 
GPAVGISVTL LGLFDAVYAS DRATFHTPFS HLGQSPEACS SYTFPKMMGS AKAAEMLLFG 

       310        320        330        340        350        360 
KKLTAREAWA QGLVTEVFPE STFETEVWTR LKTYAKLPPN SMRISKELIR KNEKEKLHAV 

       370        380        390 
NEEECTTLRA RWLSEECINA IMSFVTRKPK L 

References and documentation are available.

Number of amino acids: 391

Molecular weight: 43021.39

Theoretical pI: 9.11

Amino acid composition: 
Ala (A)  39	 10.0%
Arg (R)  17	  4.3%
Asn (N)  18	  4.6%
Asp (D)  14	  3.6%
Cys (C)   6	  1.5%
Gln (Q)  12	  3.1%
Glu (E)  25	  6.4%
Gly (G)  25	  6.4%
His (H)   4	  1.0%
Ile (I)  14	  3.6%
Leu (L)  36	  9.2%
Lys (K)  31	  7.9%
Met (M)  11	  2.8%
Phe (F)  18	  4.6%
Pro (P)  19	  4.9%
Ser (S)  31	  7.9%
Thr (T)  30	  7.7%
Trp (W)   7	  1.8%
Tyr (Y)   9	  2.3%
Val (V)  25	  6.4%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 39
Total number of positively charged residues (Arg + Lys): 48

Atomic composition:

Carbon      C	      1918
Hydrogen    H	      3040
Nitrogen    N	       518
Oxygen      O	       570
Sulfur      S	        17

Formula: C1918H3040N518O570S17
Total number of atoms: 6063

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    52285
Abs 0.1% (=1 g/l)   1.215, assuming all pairs of Cys residues form cystines


Ext. coefficient    51910
Abs 0.1% (=1 g/l)   1.207, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 43.70
This classifies the protein as unstable.



Aliphatic index: 78.39

Grand average of hydropathicity (GRAVY): -0.242