ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MADGEDIQPL VCDNGTGMVK AGFAGDDAPR AVFPSIVGRP RHTGVMVGMG QKDAYVGDEA 

        70         80         90        100        110        120 
QSKRGILTLK YPIEHGIVSN WDDMEKIWHH TFYNELRVAP EEHPVLLTEA PLNPKANREK 

       130        140        150        160        170        180 
MTQIMFETFN TPAMYVAIQA VLSLYASGRT TGIVLDSGDG VSHTVPIYEG YALPHAILRL 

       190        200        210        220        230        240 
DLAGRDLTDY LMKILTERGY SFTTSAEREI VRDVKEKLAY IALDYEQEME TANTSSSVEK 

       250        260        270        280        290        300 
SYELPDGQVI TIGGERFRCP EVLFQPSLVG MEAAGIHETT YNSIMKCDVD IRKDLYGNIV 

       310        320        330        340        350        360 
LSGGTTMFPG IADRMSKEIT ALAPSSMKIK VVAPPERKYS VWIGGSILAS LSTFQQMWIA 

       370 
KAEYDESGPS IVHRKCF 

References and documentation are available.

Number of amino acids: 377

Molecular weight: 41674.61

Theoretical pI: 5.23

Amino acid composition: 
Ala (A)  30	  8.0%
Arg (R)  18	  4.8%
Asn (N)   9	  2.4%
Asp (D)  22	  5.8%
Cys (C)   4	  1.1%
Gln (Q)  10	  2.7%
Glu (E)  28	  7.4%
Gly (G)  31	  8.2%
His (H)   9	  2.4%
Ile (I)  27	  7.2%
Leu (L)  27	  7.2%
Lys (K)  19	  5.0%
Met (M)  16	  4.2%
Phe (F)  11	  2.9%
Pro (P)  20	  5.3%
Ser (S)  25	  6.6%
Thr (T)  24	  6.4%
Trp (W)   4	  1.1%
Tyr (Y)  16	  4.2%
Val (V)  27	  7.2%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 50
Total number of positively charged residues (Arg + Lys): 37

Atomic composition:

Carbon      C	      1851
Hydrogen    H	      2909
Nitrogen    N	       491
Oxygen      O	       562
Sulfur      S	        20

Formula: C1851H2909N491O562S20
Total number of atoms: 5833

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    46090
Abs 0.1% (=1 g/l)   1.106, assuming all pairs of Cys residues form cystines


Ext. coefficient    45840
Abs 0.1% (=1 g/l)   1.100, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 34.27
This classifies the protein as stable.



Aliphatic index: 84.59

Grand average of hydropathicity (GRAVY): -0.181