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ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MADQLNNEPG QPTPLMSIRF DQQQHESAAA NGNENGNGNA NGDGDASEDA VDAEKTPGEL

70 80 90 100 110 120
VLPKALEDVL ALKDQRAAEF TVDADSQGGS GGATQDGDEA DVGEDSEEDA DNQVNGSASQ

130 140 150 160 170 180
KTGKQSKAER NKKKKKRKKQ NRKIRHQIEF ARQQQLAQAE ENEPEAKDSE TKAHGSEDEQ

190 200 210 220 230 240
VAEKEKKDKR KESRSKRRKD RSDEKDTDKK AGEANDENVT IEYVPEKITI ADLAPMYRQF

250 260 270 280 290 300
YRVFEIFKLE NKPKPVEKDK SSHDSESHPR DKKATDKQLE DEDDDGDDDE ERKEDKEKLS

310 320 330 340 350 360
KRKLKKLTRL SVAELKQLVS RPDVVEMHDV TARDPKLLVQ LKAYRNTVQV PRHWCFKRKY

370 380 390 400 410 420
LQGKRGIEKP PFDLPAFIKK TGIMEMRESL QEREDAKTLK AKMRERVRPK MGKIDIDYQK

430 440 450 460 470 480
LHDAFFKWQT KPRMTIHGDL YYEGKEFETR LKEKKPGDLS EELRIALGMP VGPNSHKIPP

490 500 510 520 530 540
PWLIAQQRYG PPPSYPNLKI PGLNAPIPDG TSFGYHAGGW GKPPVDENGK PLYGDVFGTN

550 560 570 580 590 600
ILDLDNGVDE ADIERNQWGE LESESEESSE EEEEDGEDLG DQQDETGLVT PVEGLVTPSG

610 620 630 640 650 660
LTSVPAGMET PENIELRKKK IEAEMEDNET PVLYQVLPEK RTDRIGASMM GSTHVYDVSG

670 680 690 700 710 720
SGANKQPPVR STTDREGIVE LALDPSELDL DNDAMAQRYE QQMREQQNHL QKEDLSDMLA

730 740
EHVARQKSKR KRQQTDPAKT TKKYKEFKF


References and documentation are available.

Number of amino acids: 749 Molecular weight: 84781.08 Theoretical pI: 5.21
Amino acid composition: 
Ala (A) 51 6.8% Arg (R) 44 5.9% Asn (N) 29 3.9% Asp (D) 69 9.2% Cys (C) 1 0.1% Gln (Q) 43 5.7% Glu (E) 85 11.3% Gly (G) 50 6.7% His (H) 14 1.9% Ile (I) 24 3.2% Leu (L) 51 6.8% Lys (K) 81 10.8% Met (M) 17 2.3% Phe (F) 16 2.1% Pro (P) 45 6.0% Ser (S) 40 5.3% Thr (T) 33 4.4% Trp (W) 5 0.7% Tyr (Y) 16 2.1% Val (V) 35 4.7% Pyl (O) 0 0.0% Sec (U) 0 0.0% (B) 0 0.0% (Z) 0 0.0% (X) 0 0.0%
Total number of negatively charged residues (Asp + Glu): 154 Total number of positively charged residues (Arg + Lys): 125 Atomic composition: Carbon C 3652 Hydrogen H 5845 Nitrogen N 1067 Oxygen O 1219 Sulfur S 18 Formula: C3652H5845N1067O1219S18 Total number of atoms: 11801 Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 51340 Abs 0.1% (=1 g/l) 0.606, assuming all pairs of Cys residues form cystines Ext. coefficient 51340 Abs 0.1% (=1 g/l) 0.606, assuming all Cys residues are reduced Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo). Instability index: The instability index (II) is computed to be 46.53 This classifies the protein as unstable. Aliphatic index: 59.41 Grand average of hydropathicity (GRAVY): -1.204