ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MADSSFSLPP LCERISYTNY FLRAVYLTVL GLFFSLLLHR IRHTSEYDNV WLVAFFCESC 

        70         80         90        100        110        120 
FFLVCLLITC LKWSPADTKP FPDRLDERVH DLPSVDMFVP TADPVREPPI MVVDTVLSLL 

       130        140        150        160        170        180 
AVNYPANKLA CYVSDDGCSP LTYFSLKEAS KFAKIWVPFC KKYNTRVRAP SRYFLKPISV 

       190        200        210        220        230        240 
ATEDYEFNRD WEKTKREYEK LRRKVEDATG DSHMLDVEDD FEAFSNTKPN DHSTLVKVVW 

       250        260        270        280        290        300 
ENKGGVGDEK EIPHIIYISR EKRPNYVHNQ KCGAMNFLAR VSGLMTNAPY ILNVDCDMYA 

       310        320        330        340        350        360 
NDADVVRQAM CILLQESLNM KHCAFVQFRQ EFYDSSTELI VVLQSHLGRG IAGIQGPIYI 

       370        380        390        400        410        420 
GSGCVHTRRV MYGLSPDDFE VDGSLSSVAT REFLVKDSLA RRFGNSKEMM KSVVDAIQRN 

       430        440        450        460        470        480 
PNPQNILTNS IEAAREVGHC QYEYQTSWGN TIGWLYDSVA EDLNTSIGIH SRGWTSSYIS 

       490        500        510        520        530        540 
PDTPAFLGSM PAGVPEALLQ QRRWATGWIE ILFNKQSPLR GLFSKKIRFR QRLAYLCIIT 

       550        560        570        580        590        600 
CLRSIPELIY CLLPAYCLLH NSTLFPKGLY LGITVTLVGI HCLYTLWEFM SLGYSVQSWL 

       610        620        630        640        650        660 
VSQSVWRIVA TSSWLFSIFD ITLKLLGISE TVFIITKKTV AGTKSALGSG PSQGEDVGPN 

       670        680        690        700        710        720 
SDLFKFEFDG SLCFLPGTFI VLVNIAALAV FSVGLQRSSY SHEGGGSGLA EACGCVLVMM 

       730        740        750 
LFLPFLMGLF KKGKYGTPLS TLSIAGFLAV LFVVFSV 

References and documentation are available.

Number of amino acids: 757

Molecular weight: 85061.32

Theoretical pI: 6.74

Amino acid composition: 
Ala (A)  44	  5.8%
Arg (R)  37	  4.9%
Asn (N)  27	  3.6%
Asp (D)  37	  4.9%
Cys (C)  22	  2.9%
Gln (Q)  19	  2.5%
Glu (E)  37	  4.9%
Gly (G)  48	  6.3%
His (H)  15	  2.0%
Ile (I)  42	  5.5%
Leu (L)  85	 11.2%
Lys (K)  35	  4.6%
Met (M)  17	  2.2%
Phe (F)  45	  5.9%
Pro (P)  36	  4.8%
Ser (S)  68	  9.0%
Thr (T)  39	  5.2%
Trp (W)  14	  1.8%
Tyr (Y)  30	  4.0%
Val (V)  60	  7.9%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 74
Total number of positively charged residues (Arg + Lys): 72

Atomic composition:

Carbon      C	      3868
Hydrogen    H	      5973
Nitrogen    N	       993
Oxygen      O	      1089
Sulfur      S	        39

Formula: C3868H5973N993O1089S39
Total number of atoms: 11962

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   123075
Abs 0.1% (=1 g/l)   1.447, assuming all pairs of Cys residues form cystines


Ext. coefficient   121700
Abs 0.1% (=1 g/l)   1.431, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 44.52
This classifies the protein as unstable.



Aliphatic index: 94.23

Grand average of hydropathicity (GRAVY): 0.100