ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MAEEDYLPVY QLRRDSSLLG TMNKILVANR GEIPIRIFRT AHELSMNTVA IYSHEDRLSM 

        70         80         90        100        110        120 
HRLKADEAYV IGERGQYSPV QAYLAIDEII KIAVKHNVNM IHPGYGFCSE NSEFARKVEE 

       130        140        150        160        170        180 
NGILWVGPSD TVIDAVGDKV SARNLAYAAN VPTVPGTPGP IEDVAQATAF VEEYGYPVII 

       190        200        210        220        230        240 
KAAFGGGGRG MRVVREGDDI EDAFLRASSE AKTAFGNGTV FIERFLDKPK HIEVQLLADN 

       250        260        270        280        290        300 
YGNVIHLFER DCSVQRRHQK VARNCSAKTL PVEVRNAILN DAVKLAKTAN YRNAGTAEFL 

       310        320        330        340        350        360 
VDSQNRHYFI EINPRIQVEH TITEEITGVD IVAAQIQIAA GASLEQLGLL QEKITTRGFA 

       370        380        390        400        410        420 
IQCRITTEDP TKNFQPDTGK IEVYRSSGGN GVRLDGGNGF AGAVISPHYD SMLVKCSTSG 

       430        440        450        460        470        480 
SNYEIRRRKM IRALVEFRIR GVKTNIPFLL ALLTHPVFMT SECWTTFIDD TPELFKILTS 

       490        500        510        520        530        540 
QNRAQKLLAY LGDLAVNGSS IKGQIGLPKL HKEADIPSIT DINGDVIDVS IPPPDGWRQF 

       550        560        570        580        590        600 
LLEKGPEQFA QQVRAFPGLM IMDTTWRDAH QSLLATRVRT HDLLNIAPAT SYALHHAFAL 

       610        620        630        640        650        660 
ECWGGATFDV SMRFLHEDPW QRLRKLRKAV PNIPFSMLLR GGNGVAYYSL PDNAIDHFLK 

       670        680        690        700        710        720 
QAKDTGVDVF RVFDALNDIE QLKVGVDAVK KAGGVVEATM CYSGDMLKPG KKYNLEYYIN 

       730        740        750        760        770        780 
LATEIVEMGT HILAVKDMAG TLKPTAAKQL ISALRRKFPS LPIHVHTHDS AGTGVASMVA 

       790        800        810        820        830        840 
CARAGADVVT VRVNSMSGMT SQPSMSAFIA SLDGEIETGI PEANAREIDA YWAEMRLLYS 

       850        860        870        880        890        900 
CFEADLKGPD PEVYQHEIPG GQLTNLLFQA QQVGLGEKWV ETKKAYEAAN RLLGDIVKVT 

       910        920        930        940        950        960 
PTSKVVGDLA QFMVSNKLSS EDVERLASEL DFPDSVLDFF EGLMGTPYGG FPEPLRTNVI 

       970        980        990       1000       1010       1020 
SGKRRKLTSR PGLTLEPYNI PAIREDLEAR FSKVTENDVA SYNMYPKVYE AYKKQQELYG 

      1030       1040       1050       1060       1070       1080 
DLSVLPTRNF LSPPKIDEER HVTIVTIETR KTLIIKCMAE GELSQSSGTR EVYFELNGEM 

      1090       1100       1110       1120       1130       1140 
RKVTVEDKNG AVETITRPKA DAHNPNEIGA PMAGVVVEVR VHENGEVKKG DPIAVLSAMK 

      1150       1160       1170       1180 
MEMVISSPVA GRIGQIAVKE NDSVDASDLI PKSSRLSKLL MFIILIILY 

References and documentation are available.

Number of amino acids: 1189

Molecular weight: 131400.38

Theoretical pI: 6.00

Amino acid composition: 
Ala (A) 105	  8.8%
Arg (R)  68	  5.7%
Asn (N)  50	  4.2%
Asp (D)  66	  5.6%
Cys (C)  11	  0.9%
Gln (Q)  38	  3.2%
Glu (E)  83	  7.0%
Gly (G)  87	  7.3%
His (H)  27	  2.3%
Ile (I)  82	  6.9%
Leu (L) 100	  8.4%
Lys (K)  65	  5.5%
Met (M)  32	  2.7%
Phe (F)  43	  3.6%
Pro (P)  58	  4.9%
Ser (S)  69	  5.8%
Thr (T)  65	  5.5%
Trp (W)   8	  0.7%
Tyr (Y)  37	  3.1%
Val (V)  95	  8.0%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 149
Total number of positively charged residues (Arg + Lys): 133

Atomic composition:

Carbon      C	      5843
Hydrogen    H	      9294
Nitrogen    N	      1608
Oxygen      O	      1747
Sulfur      S	        43

Formula: C5843H9294N1608O1747S43
Total number of atoms: 18535

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    99755
Abs 0.1% (=1 g/l)   0.759, assuming all pairs of Cys residues form cystines


Ext. coefficient    99130
Abs 0.1% (=1 g/l)   0.754, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 36.99
This classifies the protein as stable.



Aliphatic index: 91.70

Grand average of hydropathicity (GRAVY): -0.179