ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MAEQTLLSKL NALSQKVIPP ASPSQASILT EEVIRNWPER SKTLCSDFTA LESNDEKEDW 

        70         80         90        100        110        120 
LRTLFIELFD FINKNDENSP LKLSDVASFT NELVNHERQV SQASIVGKMF IAVSSTVPNI 

       130        140        150        160        170        180 
NDLTTISLCK LIPSLHEELF KFSWISSKLL NKEQTTLLRH LLKKSKYELK KYNLLVENSV 

       190        200        210        220        230        240 
GYGQLVALLI LAYYDPDNFS KVSAYLKEIY HIMGKYSLDS IRTLDVILNV SSQFITEGYK 

       250        260        270        280        290        300 
FFIALLRKSD SWPSSHVANN SNYSSLNEGG NMIAANIISF NLSQYNEEVD KENYERYMDM 

       310        320        330        340        350        360 
CCILLKNGFV NFYSIWDNVK PEMEFLQEYI QNLETELEEE STKGVENPLA MAAALSTENE 

       370        380        390        400        410        420 
TDEDNALVVN DDVNMKDKIS EETNADIESK GKQKTQQDIL LFGKIKLLER LLIHGCVIPV 

       430        440        450        460        470        480 
IHVLKQYPKV LYVSESLSRY LGRVFEYLLN PLYTSMTSSG ESKDMATALM ITRIDNGILA 

       490        500        510        520        530        540 
HKPRLIHKYK THEPFESLEL NSSYVFYYSE WNSNLTPFAS VNDLFENSHI YLSIIGPYLG 

       550        560        570        580        590        600 
RIPTLLSKIS RIGVADIQKN HGSESLHVTI DKWIDYVRKF IFPATSLLQN NPIATSEVYE 

       610        620        630        640        650        660 
LMKFFPFEKR YFIYNEMMTK LSQDILPLKV SFNKAEREAK SILKALSIDT IAKESRRFAK 

       670        680        690        700        710        720 
LISTNPLASL VPAVKQIENY DKVSELVVYT TKYFNDFAYD VLQFVLLLRL TYNRPAVQFD 

       730        740        750        760        770        780 
GVNQAMWVQR LSIFIAGLAK NCPNMDISNI ITYILKTLHN GNIIAVSILK ELIITVGGIR 

       790        800        810        820        830        840 
DLNEVNMKQL LMLNSGSPLK QYARHLIYDF RDDNSVISSR LTSFFTDQSA ISEIILLLYT 

       850        860        870        880        890        900 
LNLKANTQNS HYKILSTRCD EMNTLLWSFI ELIKHCLKGK AFEENVLPFV ELNNRFHLST 

       910        920        930        940        950        960 
PWTFHIWRDY LDNQLNSNEN FSIDELIEGA EFSDVDLTKI SKDLFTTFWR LSLYDIHFDK 

       970        980        990       1000       1010       1020 
SLYDERKNAL SGENTGHMSN RKKHLIQNQI KDILVTGISH QRAFKKTSEF ISEKSNVWNK 

      1030       1040       1050       1060       1070       1080 
DCGEDQIKIF LQNCVVPRVL FSPSDALFSS FFIFMAFRTE NLMSILNTCI TSNILKTLLF 

      1090       1100       1110       1120       1130       1140 
CCTSSEAGNL GLFFTDVLKK LEKMRLNGDF NDQASRKLYE WHSVITEQVI DLLSEKNYMS 

      1150       1160       1170       1180       1190       1200 
IRNGIEFMKH VTSVFPVVKA HIQLVYTTLE ENLINEERED IKLPSSALIG HLKARLKDAL 

      1210       1220       1230       1240       1250       1260 
ELDEFCTLTE EEAEQKRIRE MELEEIKNYE TACQNEQKQV ALRKQLELNK SQRLQNDPPK 

      1270       1280       1290       1300       1310       1320 
SVASGSAGLN SKDRYTYSRN EPVIPTKPSS SQWSYSKVTR HVDDINHYLA TNHLQKAISL 

      1330       1340       1350       1360       1370       1380 
VENDDETRNL RKLSKQNMPI FDFRNSTLEI FERYFRTLIQ NPQNPDFAEK IDSLKRYIKN 

      1390       1400       1410       1420       1430       1440 
ISREPYPDTT SSYSEAAAPE YTKRSSRYSG NAGGKDGYGS SNYRGPSNDR SAPKNIKPIS 

      1450       1460       1470       1480       1490       1500 
SYAHKRSELP TRPSKSKTYN DRSRALRPTG PDRGDGFDQR DNRLREEYKK NSSQRSQLRF 

      1510       1520       1530       1540       1550       1560 
PEKPFQEGKD SSKANPYQAS SYKRDSPSEN EEKPNKRFKK DETIRNKFQT QDYRNTRDSG 

      1570       1580       1590 
AAHRANENQR YNGNRKSNTQ ALPQGPKGGN YVSRYQR 

References and documentation are available.

Number of amino acids: 1597

Molecular weight: 183930.83

Theoretical pI: 7.55

Amino acid composition: 
Ala (A)  77	  4.8%
Arg (R)  80	  5.0%
Asn (N) 121	  7.6%
Asp (D)  83	  5.2%
Cys (C)  15	  0.9%
Gln (Q)  59	  3.7%
Glu (E) 118	  7.4%
Gly (G)  53	  3.3%
His (H)  32	  2.0%
Ile (I) 111	  7.0%
Leu (L) 171	 10.7%
Lys (K) 122	  7.6%
Met (M)  28	  1.8%
Phe (F)  74	  4.6%
Pro (P)  59	  3.7%
Ser (S) 157	  9.8%
Thr (T)  82	  5.1%
Trp (W)  15	  0.9%
Tyr (Y)  68	  4.3%
Val (V)  72	  4.5%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 201
Total number of positively charged residues (Arg + Lys): 202

Atomic composition:

Carbon      C	      8216
Hydrogen    H	     12910
Nitrogen    N	      2218
Oxygen      O	      2487
Sulfur      S	        43

Formula: C8216H12910N2218O2487S43
Total number of atoms: 25874

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   184695
Abs 0.1% (=1 g/l)   1.004, assuming all pairs of Cys residues form cystines


Ext. coefficient   183820
Abs 0.1% (=1 g/l)   0.999, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 43.16
This classifies the protein as unstable.



Aliphatic index: 86.76

Grand average of hydropathicity (GRAVY): -0.491