ProtParam
User-provided sequence:
10 20 30 40 50 60
MAESDSGEST SSVSSFISSS SSSRLSEFVD AKTELQDIYH DLSNYLSNFL TILEETVLLK
70 80 90 100 110 120
DRQMLEHLCA FSSRVEAIAK VLSRDRMKVA FFGRTSNGKS AVINALLHEK ILPSAMGHTT
130 140 150 160 170 180
SCFCQVQANG SNETEHVKVE QEDEHMELSA LSQLASAHSP GALKPSTLLQ VNMAKNRCSI
190 200 210 220 230 240
LDYDVVLMDT PGVDVTAQLD DCLDSYCMDA DVFILVLNAE STVSRVERQF FKDVASKLSR
250 260 270 280 290 300
PNLFILNNRW DKASSLEPEM EQKVKDQHME RCVNLLVDEL GVYSTAQEAW ERIYHVSALE
310 320 330 340 350 360
ALHIRNGQIT NPSGQTQQRY QEFLRFENDF SNCLAVSALK TKFGPHLLSA QKILNQLKST
370 380 390 400 410 420
LICPFIEKVS RLIDENKERR ANLNAEIEDW LILMQEDREA LQYCFEELTE MTQRVGRCVL
430 440 450 460 470 480
NDQIKTLIPS SVLSFSQPFH PEFPAQIGQY QRSLCAHLDK LLEDRVLQCL SIPLQRKILD
490 500 510 520 530 540
IEKEIGLPIA ENSCDWQLIY GLDCQSYMSD FQPDLRFRFS LGFTALWHRL EGNLPLHASP
550 560 570 580 590 600
FRIQKLQNGH KKCSPLPPLV NGNHWQMLES LVKSKGSLGT VLLSAMAIRS FNWPIVLILG
610 620 630 640 650 660
GLVGSFYIYE YAAWTTAAQE RSFKSQYARL LQQRLRSDVQ QTVSGFELQL RQHLATVRNC
670 680 690 700 710
WEAQSNETLN DLNVRTAELT KQIQSMEVLQ LSLKKFRDKG QLLASRLGDF QETYLTKS
References and
documentation are available.
Number of amino acids: 718
Molecular weight: 81565.01
Theoretical pI: 5.78
Total number of negatively charged residues (Asp + Glu): 88
Total number of positively charged residues (Arg + Lys): 74
Atomic composition:
Carbon C 3603
Hydrogen H 5716
Nitrogen N 996
Oxygen O 1095
Sulfur S 33
Formula: C
3603H
5716N
996O
1095S
33
Total number of atoms: 11443
Extinction coefficients:
Extinction coefficients are in units of M
-1 cm
-1, at 280 nm measured in water.
Ext. coefficient 74340
Abs 0.1% (=1 g/l) 0.911, assuming all pairs of Cys residues form cystines
Ext. coefficient 73340
Abs 0.1% (=1 g/l) 0.899, assuming all Cys residues are reduced
Estimated half-life:
The N-terminal of the sequence considered is M (Met).
The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Instability index:
The instability index (II) is computed to be 45.51
This classifies the protein as unstable.
Aliphatic index: 93.04
Grand average of hydropathicity (GRAVY): -0.261