ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MAGAIENARK EIKRISLEDH AESEYGAIYS VSGPVVIAEN MIGCAMYELV KVGHDNLVGE 

        70         80         90        100        110        120 
VIRIDGDKAT IQVYEETAGL TVGDPVLRTG KPLSVELGPG LMETIYDGIQ RPLKAIKEES 

       130        140        150        160        170        180 
QSIYIPRGID TPALDRTIKW QFTPGKFQVG DHISGGDIYG SVFENSLISS HKILLPPRSR 

       190        200        210        220        230        240 
GTITWIAPAG EYTLDEKILE VEFDGKKSDF TLYHTWPVRV PRPVTEKLSA DYPLLTGQRV 

       250        260        270        280        290        300 
LDALFPCVQG GTTCIPGAFG CGKTVISQSL SKYSNSDAII YVGCFAKGTN VLMADGSIEC 

       310        320        330        340        350        360 
IENIEVGNKV MGKDGRPREV IKLPRGRETM YSVVQKSQHR AHKSDSSREV PELLKFTCNA 

       370        380        390        400        410        420 
THELVVRTPR SVRRLSRTIK GVEYFEVITF EMGQKKAPDG RIVELVKEVS KSYPISEGPE 

       430        440        450        460        470        480 
RANELVESYR KASNKAYFEW TIEARDLSLL GSHVRKATYQ TYAPILYEND HFFDYMQKSK 

       490        500        510        520        530        540 
FHLTIEGPKV LAYLLGLWIG DGLSDRATFS VDSRDTSLME RVTEYAEKLN LCAEYKDRKE 

       550        560        570        580        590        600 
PQVAKTVNLY SKVVRGNGIR NNLNTENPLW DAIVGLGFLK DGVKNIPSFL STDNIGTRET 

       610        620        630        640        650        660 
FLAGLIDSDG YVTDEHGIKA TIKTIHTSVR DGLVSLARSL GLVVSVNAEP AKVDMNGTKH 

       670        680        690        700        710        720 
KISYAIYMSG GDVLLNVLSK CAGSKKFRPA PAAAFARECR GFYFELQELK EDDYYGITLS 

       730        740        750        760        770        780 
DDSDHQFLLA NQVVVHNCGE RGNEMAEVLM EFPELYTEMS GTKEPIMKRT TLVANTSNMP 

       790        800        810        820        830        840 
VAAREASIYT GITLAEYFRD QGKNVSMIAD SSSRWAEALR EISGRLGEMP ADQGFPAYLG 

       850        860        870        880        890        900 
AKLASFYERA GKAVALGSPD RTGSVSIVAA VSPAGGDFSD PVTTATLGIT QVFWGLDKKL 

       910        920        930        940        950        960 
AQRKHFPSIN TSVSYSKYTN VLNKFYDSNY PEFPVLRDRM KEILSNAEEL EQVVQLVGKS 

       970        980        990       1000       1010       1020 
ALSDSDKITL DVATLIKEDF LQQNGYSTYD AFCPIWKTFD MMRAFISYHD EAQKAVANGA 

      1030       1040       1050       1060       1070 
NWSKLADSTG DVKHAVSSSK FFEPSRGEKE VHGEFEKLLS TMQERFAEST D 

References and documentation are available.

Number of amino acids: 1071

Molecular weight: 118636.69

Theoretical pI: 5.82

Amino acid composition: 
Ala (A)  80	  7.5%
Arg (R)  55	  5.1%
Asn (N)  38	  3.5%
Asp (D)  61	  5.7%
Cys (C)  12	  1.1%
Gln (Q)  27	  2.5%
Glu (E)  81	  7.6%
Gly (G)  83	  7.7%
His (H)  20	  1.9%
Ile (I)  63	  5.9%
Leu (L)  87	  8.1%
Lys (K)  71	  6.6%
Met (M)  23	  2.1%
Phe (F)  41	  3.8%
Pro (P)  45	  4.2%
Ser (S)  87	  8.1%
Thr (T)  64	  6.0%
Trp (W)  10	  0.9%
Tyr (Y)  43	  4.0%
Val (V)  80	  7.5%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 142
Total number of positively charged residues (Arg + Lys): 126

Atomic composition:

Carbon      C	      5277
Hydrogen    H	      8310
Nitrogen    N	      1422
Oxygen      O	      1615
Sulfur      S	        35

Formula: C5277H8310N1422O1615S35
Total number of atoms: 16659

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   119820
Abs 0.1% (=1 g/l)   1.010, assuming all pairs of Cys residues form cystines


Ext. coefficient   119070
Abs 0.1% (=1 g/l)   1.004, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 33.01
This classifies the protein as stable.



Aliphatic index: 83.75

Grand average of hydropathicity (GRAVY): -0.294