ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MAGQVLDGKA CAQQFRSNIA NEIKSIQGHV PGFAPNLAII QVGNRPDSAT YVRMKRKAAE 

        70         80         90        100        110        120 
EAGIVANFIH LDESATEFEV LRYVDQLNED PHTHGIIVQL PLPAHLDEDR ITSRVLAEKD 

       130        140        150        160        170        180 
VDGFGPTNIG ELNKKNGHPF FLPCTPKGII ELLHKANVTI EGSRSVVIGR SDIVGSPVAE 

       190        200        210        220        230        240 
LLKSLNSTVT ITHSKTRDIA SYLHDADIVV VAIGQPEFVK GEWFKPRDGT SSDKKTVVID 

       250        260        270        280        290        300 
VGTNYVADPS KKSGFKCVGD VEFNEAIKYV HLITPVPGGV GPMTVAMLMQ NTLIAAKRQM 

       310        320        330        340        350        360 
EESSKPLQIP PLPLKLLTPV PSDIDISRAQ QPKLINQLAQ ELGIYSHELE LYGHYKAKIS 

       370        380        390        400        410        420 
PKVIERLQTR QNGKYILVSG ITPTPLGEGK STTTMGLVQA LTAHLGKPAI ANVRQPSLGP 

       430        440        450        460        470        480 
TLGVKGGAAG GGYSQVIPMD EFNLHLTGDI HAIGAANNLL AAAIDTRMFH ETTQKNDATF 

       490        500        510        520        530        540 
YNRLVPRKNG KRKFTPSMQR RLNRLGIQKT NPDDLTPEEI NKFARLNIDP DTITIKRVVD 

       550        560        570        580        590        600 
INDRMLRQIT IGQAPTEKNH TRVTGFDITV ASELMAILAL SKDLRDMKER IGRVVVAADV 

       610        620        630        640        650        660 
NRSPVTVEDV GCTGALTALL RDAIKPNLMQ TLEGTPVLVH AGPFANISIG ASSVIADRVA 

       670        680        690        700        710        720 
LKLVGTEPEA KTEAGYVVTE AGFDFTMGGE RFFNIKCRSS GLTPNAVVLV ATVRALKSHG 

       730        740        750        760        770        780 
GAPDVKPGQP LPSAYTEENI EFVEKGAANM CKQIANIKQF GVPVVVAINK FETDTEGEIA 

       790        800        810        820        830        840 
AIRKAALEAG AFEAVTSNHW AEGGKGAIDL AKAVIEASNQ PVDFHFLYDV NSSVEDKLTT 

       850        860        870        880        890        900 
IVQKMYGGAA IDILPEAQRK IDMYKEQGFG NLPICIAKTQ YSLSHDATLK GVPTGFTFPI 

       910        920        930        940 
RDVRLSNGAG YLYALAAEIQ TIPGLATYAG YMAVEVDDDG EIDGLF 

References and documentation are available.

Number of amino acids: 946

Molecular weight: 102205.13

Theoretical pI: 6.37

Amino acid composition: 
Ala (A)  91	  9.6%
Arg (R)  41	  4.3%
Asn (N)  43	  4.5%
Asp (D)  52	  5.5%
Cys (C)   7	  0.7%
Gln (Q)  35	  3.7%
Glu (E)  55	  5.8%
Gly (G)  79	  8.4%
His (H)  22	  2.3%
Ile (I)  72	  7.6%
Leu (L)  77	  8.1%
Lys (K)  59	  6.2%
Met (M)  19	  2.0%
Phe (F)  32	  3.4%
Pro (P)  54	  5.7%
Ser (S)  45	  4.8%
Thr (T)  64	  6.8%
Trp (W)   2	  0.2%
Tyr (Y)  21	  2.2%
Val (V)  76	  8.0%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 107
Total number of positively charged residues (Arg + Lys): 100

Atomic composition:

Carbon      C	      4543
Hydrogen    H	      7308
Nitrogen    N	      1252
Oxygen      O	      1369
Sulfur      S	        26

Formula: C4543H7308N1252O1369S26
Total number of atoms: 14498

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    42665
Abs 0.1% (=1 g/l)   0.417, assuming all pairs of Cys residues form cystines


Ext. coefficient    42290
Abs 0.1% (=1 g/l)   0.414, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 33.88
This classifies the protein as stable.



Aliphatic index: 94.34

Grand average of hydropathicity (GRAVY): -0.124