ProtParam
User-provided sequence:
10 20 30 40 50 60
MAGYLSPAAY LYVEEQEYLQ AYEDVLERYK DERDKVQKKT FTKWINQHLM KVRKHVNDLY
70 80 90 100 110 120
EDLRDGHNLI SLLEVLSGDT LPREKGRMRF HRLQNVQIAL DYLKRRQVKL VNIRNDDITD
130 140 150 160 170 180
GNPKLTLGLI WTIILHFQIS DIHVTGESED MSAKERLLLW TQQATEGYAG VRCENFTTCW
190 200 210 220 230 240
RDGKLFNAII HKYRPDLIDM NTVAVQSNLA NLEHAFYVAE KIGVIRLLDP EDVDVSSPDE
250 260 270 280 290 300
KSVITYVSSL YDAFPKVPEG GEGIGANDVE VKWIEYQNMV NYLIQWIRHH VVTMSERTFP
310 320 330 340 350 360
NNPLELKALY NQYLQFKEKE IPPKETEKSK IKRLYKLLEI WIEFGRIKLL QGYHPNDIEK
370 380 390 400 410 420
EWGKLIIAML EREKALRPEV ERLDMLQQIA TRVQRDSVSC EDKLMLARNA LQSDSKRLES
430 440 450 460 470 480
GVQFQNEAEI AGYILECENL LRQHVIDVQI LLDGKYYQAE QLVQRVAKLR DEILALRNEC
490 500 510 520 530 540
SAVYSKGRML TTEQTKLMIS GITQSLNSGF AQTLHPSLNS GLTQSLTPSL TSSSVTSGLS
550 560 570 580 590 600
SGMTSRLTPS VTPAYTPGFP SVVAPNFSVG VEPNSLQTLK LMQIRKPLLK SSLLDQNLTE
610 620 630 640 650 660
EEVNMKFVQD LLNWVDEMQV QLDRTEWGSD LPSVESHLEN HKNVHRAIEE FESSLKEAKI
670 680 690 700 710 720
SEIQMTAPLK LSYTDKLHRL ESQYAKLLNT SRNQERHLDT LHNFVTRATN ELIWLNEKEE
730 740 750 760 770 780
SEVAYDWSER NSNVARKKGY HAELMRELEQ KEESIKAVQE IAEQLLLESH PARLTIEAYK
790 800 810 820 830 840
AAMQTQWSWI LQLCQCVEQH IQENTAYFEF FNDAKEATDY LRNLKDAIQR KYVCDRSSSI
850 860 870 880 890 900
RKLEDLVQES MEKEELLQYR SVVAGLMGRA KTVVQLKPRN PDNPLKTSIP IKAICDYRQI
910 920 930 940 950 960
EITIYKDDEC VLANNSHRAK WKVISPTGNE AMVPSVCFTV PPPNKEAVDF ANRIEQQYQS
970 980 990 1000 1010 1020
VLTLWHESHV NMKSIVSWHY LVNEIDRIRA SNVASIKTML PGEHQQVLSN LQSRLEDFLE
1030 1040 1050 1060 1070 1080
DSQESQIFSG SDITQLEKEV NVCRKYYQEL LKSAEREEQE ESVYNLYVSE VRNIRLRLES
1090 1100 1110 1120 1130 1140
CEDRLIRQIR TPLERDDLHE SMLRITEQEK LKKELERLKD DLEAITNKCE EFFSQAADSP
1150 1160 1170 1180 1190 1200
SVPALRSELS VVLQSMSQIY SMSATYVEKL KTVNLVLKNT QAAEALVKLY ETKLCEEEAV
1210 1220 1230 1240 1250 1260
IADKNNIENL MSTLKQWRSE VDEKREVFHA LEDELQKAKA ISDEMFKTHK ERDLDFDWHK
1270 1280 1290 1300 1310 1320
EKADQLVERW QSVHVQIDNR LRDLEGIGKS LKHYRDSYHP LDDWIQQIET TQRKIQENQP
1330 1340 1350 1360 1370 1380
ENSKALAVQL NQQKMLVSEI EVKQSKMDEC QKYSEQYSAA VKDYELQTMT YRAMVDSQQK
1390 1400 1410 1420 1430 1440
SPMKRRRIQS SADLIIQEFM DLRTRYTALV TLMTQYIKFA GDSLKRLEEE EKSLDEEKKQ
1450 1460 1470 1480 1490 1500
HVEKAKELQK WVSNISETLG DGERAGKPHF SKQQISSKEI SAKKEQFSEA LQNTQIFLAK
1510 1520 1530 1540 1550 1560
HGDKLTEEDR SDLEKQVKTL QEGYNLLFSE SLKQQELQPS GEAKVKVEEK PDKVIAGTIN
1570 1580 1590 1600 1610 1620
QTTGEVLSVF QAVLRGLIDY ETGIRLLEAQ LVISGLISPE LRKCFDLKDA ERHGLVDEQI
1630 1640 1650 1660 1670 1680
LGQLKELNEA KQIISTASPT MIPVLDSLDR GVISESVAIR VLEILLSTDS LVVPATGEHL
1690 1700 1710 1720 1730 1740
TLQKAFQQNL ISSALFSKVL ERQAACKDLI DPCTSEKVSL TDMVQRSILQ ENTRMWLLPV
1750 1760 1770 1780 1790 1800
RPQEAGRITL KCGRSVSILR AAHEGIIDRE TMFRLLGAQL LSGGLVDCNS GQKMTVEEAL
1810 1820 1830 1840 1850 1860
AEGVIDRDTA SSILTYQVRT GGILHSNPAK RLTVDEAVQC ELITSSSALL VLEAQRGYVG
1870 1880 1890 1900 1910 1920
LIWPHSGEIF PTASSLEQEL ITNELACKIL NGRQKIAALY FPETSQVIDL DAARRLGIID
1930 1940 1950 1960 1970 1980
NNTASVLKHV TLPDKMPDLG DLEACKNARK WLSFCKFQPS TAHHYTQEED GSDGDEPVAA
1990 2000 2010 2020 2030 2040
QSSEQTKKLF LSYLMVNSYM DANTGRRLLL HDGDLEEAVG MLLESCGAEL GAGTAVRESL
2050 2060 2070 2080 2090 2100
SVLPVPDASP DCASSREKHG CSTLAAGSDK CHYRHPGHKG PLENAKWDLN GELCEMGNNE
2110 2120 2130 2140 2150 2160
DSGELPRLEN LTDTTVAQKA GGPSSVRVPK PTSYSTQPEL KNQSELDTEA SPDEGIHSGV
2170 2180 2190 2200 2210 2220
CTSETSRLCD ASETEDEDHI QKGPSVFDYS PRLSALLSHD LLRHSQGSFS DTPKNTGYLC
2230 2240 2250 2260 2270 2280
EASTLSSGDQ SVLADQSTGE KLQDQFLGIA AISVSLQGAP CGQTPVDNGC SNCQVHYSSD
2290 2300 2310 2320 2330 2340
EYMSDASAES GTTRQTSETE KTGSEVEDDS CTMIPGDGSC NANPSACRPL SLKGAIDAGD
2350 2360 2370 2380 2390 2400
YETSLLAGQQ SDTATDSDSD DYFYDTPLFE DEDHDSLILQ GDDHDCLQPE DYDTLQEEND
2410 2420 2430 2440 2450 2460
KTPPPDDIFY DVLKENENPE SSPGGMDESL SAGGKVHFPQ GFLVGTKRPE LYVVDQKQFN
2470 2480 2490 2500 2510 2520
LGDSDKMRER LAEPVPESET PSDLEHSESD SLTDGEITGR KESLGTSVTP GGRWRGDREE
2530 2540 2550 2560 2570 2580
CDTSQESQSD TDGVGFVQSI ESSRLYMSDG SDRDEEDNGT YSSEDDDDRG GGGQEVAGEN
2590 2600 2610 2620 2630 2640
GEPSDPASHN QLYTATVKES GAETQSVRDT ILLDRMHGYS PLEKQQRGRV LQPESAGKRG
2650 2660 2670 2680 2690 2700
RDTERSNHPE LTTEADEEDR ASVSTHMATT GVSLSNAQGT ASENVELVQG PGSTDILKDE
2710 2720 2730 2740 2750 2760
DEYLENGSPK NGQPSNKIVC SEAGLGGGPS EESHLSFTVS NRGQRGTGRG QVKGRDGKNS
2770 2780 2790 2800 2810 2820
QGVGEMSIQE TGFREDGGLM SSPEEGEEER CLNPFPNGIA TGSPNTGESL FTPLLTHTEE
2830 2840 2850 2860 2870 2880
LRHRGDPNTA TMTLDCEAKD GQTGLRESPV LLETLAEIFD TSASKETHAD PTSALRSSGV
2890 2900 2910 2920 2930 2940
KSQVKEDSLT GGSEKETGPF TSPERCDKCV NVDVLESNKH TPSCAFIASP PMKDDLPTVT
2950 2960 2970 2980 2990 3000
NAEEKPVIPQ GDWPSGAKIQ PSGACVKGSM SEGKAGIPHF TPEHSDTTLS LLPQKSVAEC
3010 3020 3030 3040 3050 3060
GGNTDFVQAQ LHMNGVRNTS DNTLDVGCPR LESSREKERT EKQPHGERTS SPRPQERVHT
3070 3080 3090 3100 3110 3120
PEFGEDGGTL KSGLDKVQMN LQDVGDPSAC TGTTISIQNL IKRAILSELP NETSNVPSPG
3130 3140 3150 3160 3170 3180
VSPINNSSEE KAENRGDPLC IASLLEILKQ DQHTQETPGT SELIKVLTQT ACNPEERGLV
3190 3200 3210 3220 3230 3240
SGLFPPQLKN VFCKLLLDGY SAEREQAEAL KQTPGAAPEM VEEKPCDCSD LKSKEGNHYT
3250 3260 3270 3280 3290 3300
PNPQTVREAG VEHSGVHTAA LPRDEEFGEL CSEPPDHSEC TSGSKEISSD DNTKEKCSNG
3310 3320 3330 3340 3350 3360
LQQCLQHTEK MHEYLALLQD MKPPLDNQAA MENSLEALKN QLKQLETFEL GLAPMAVFLR
3370 3380 3390 3400 3410 3420
KDLKLAEEFL KSFPSDLPGR HHEELSKSHE RLQNAFESLS SVSSQRMKLI TLAIDTETSK
3430 3440 3450 3460 3470 3480
LAVRHEDFLH RLTSYSDWVS EKSRSVADIQ TVNVQDTELV KNSVKFLKNV LTDLSHTKVQ
3490 3500 3510 3520 3530 3540
LETTAFDIQS FISDYAQDLS PNQSRQLLRL LNTTQKCFLD VQELVTSEVV RLETLLQLEQ
3550 3560 3570 3580 3590 3600
ELGHQKVVAE RQQEYKEKLQ GLCDLLTQTE NRLISHQETF VIGDGTVELK KYQSKQEELQ
3610 3620 3630 3640 3650 3660
RDMQGSTQAL AEIVRNTEIF LKESGDELSQ EDKALIEQKL NEAKVKCEQL NLKAEQSTKE
3670 3680 3690 3700 3710 3720
LDKVVTAALK EETEKVAAAR QLEESKTKIE NLLNWLSNVE KDSEGSGRLH TQPLEQNGTH
3730 3740 3750 3760 3770 3780
LHEGDGTSEA GEEDEVNGNL LETDAEGHGG MTEGNLNQQY EKVKAQHEKI VAQHQAVIMA
3790 3800 3810 3820 3830 3840
TQSAQALLEK QGHHLSPEEK EKLQANVQEL KAHYETVLAE CEKKVKLTHS LQEELEKFDA
3850 3860 3870 3880 3890 3900
DCGEFEHWLQ QSEQELENLE AGADDLSGLT DKLARQKSFS EDVISHKGDL RYITISGNRV
3910 3920 3930 3940 3950 3960
MEAAKSCSKR DGDRIGKDSL ETSATHREVQ TKLDQVTDRF RCLYSKCSVL GNNLKDLVDK
3970 3980 3990 4000 4010 4020
YQHYEDASCG LLSGLQACEA KASRHLLEPI ALDPKNLQRQ LEETKALQGQ ISSQQAAVEK
4030 4040 4050 4060 4070 4080
LKKTAEVLLD AKGSLLPAKN DIQKTLDDIV GRYDDLSKSV NERNEKLQIT LTRSLSVQDG
4090 4100 4110 4120 4130 4140
LDEMLDWMGS VESSLVKQGQ VPLNSTALQD LISKNIMLDQ DITGRQSSIN AMNEKVKTFI
4150 4160 4170 4180 4190 4200
ETTDPSTASS LQAKMKDLSA RFSEASQKHK EKLAKMVELK SKVEEFEKLS DKLQTFLETQ
4210 4220 4230 4240 4250 4260
SQALTEVDMP GKDVPELSQH MQESTTKFLE HRKDLEALHS LLKEISSHGL PGDKALVFEK
4270 4280 4290 4300 4310 4320
TNNLSKKFKE LEDTIQEKKE ALSSCQEQLS AFHDLAQSLK TWIKETTKQV PIVKPSFGTE
4330 4340 4350 4360 4370 4380
DLEKSLEETK KLQEKWSLKT PEIHKANNSG VSLCNLLSAL ISPAKAIAAA RSGGVILNGE
4390 4400 4410 4420 4430 4440
GTDTNTQDFL ANKGLTSIKT DMTDISHSYE DLGLLLKDKI VELNTKLSKL QKAQEESSAM
4450 4460 4470 4480 4490 4500
MQWLQKMNKT ASRWRQTPTP ADSESVKIQV EQNKSFEAEL KQNVNKVQEL KDKLAELLKE
4510 4520 4530 4540 4550 4560
NPEAPEAPSW KQTMAEMDTK WQELNQLTID RQQKLEESSN NLSQFQTTEA QLKQWLVEKE
4570 4580 4590 4600 4610 4620
LMVSVLGPLS TDPNMLNTQK QQAQILLQEF DTRKPQYEQL TAAGQGILSR PGEDPSLHGI
4630 4640 4650 4660 4670 4680
VKEQLAAVTQ KWDNLTGQLR DRCDWIDQAI VKSTQYQSLL RSLSGTLTEL DEKLSSSLIS
4690 4700 4710 4720 4730 4740
GTLPDAVNQQ LEAAQKLKQE IEQQTPKIKE AQTLCEDLSA LVKEEYLRAE LSRQLEGVLK
4750 4760 4770 4780 4790 4800
SFKDIEQKTE NHVQHLQSAC ASSHQFQQMS KDFQAWLDAK KEEQRNSPPI SAKLDVLESL
4810 4820 4830 4840 4850 4860
LKAQKDFGKT FTEQSNIYEK TVAEGENLLS KTQGAEKAAL QLQLNTIKTD WDRFRKQVKE
4870 4880 4890 4900 4910 4920
REEKLKESLE KALRYREQVD TLQPWVDKCQ HSLESVKLSL DPADTERSIT ELKTLQKEMD
4930 4940 4950 4960 4970 4980
HHFGTLELLN NSANSLLSVC EVDKEVVTEG NKSLIQKVNV VTEQLQSKKV SLENMAQKFK
4990 5000 5010 5020 5030 5040
EFQEVSKDAK RQLQDTKEQL EVYQSLGPQA CSNKHLTMLQ AQQKSLQTLK HQVDSARRLA
5050 5060 5070 5080 5090 5100
QDLVMEATDP KGTSDVLSQA ETLAEEHRGL SQQVDEKCSF LETKLQGLGH FQNTIREMFS
5110 5120 5130 5140 5150 5160
QFTEFDDELD SMAPVGRDVE TLQKQKASMQ TFLKKLEALI TSNDSANRTC KMMLATEETS
5170 5180 5190 5200 5210 5220
PDLIGVKRDL EALSKQCNKL LDRAKTREEQ VSGATEKLEE FHRKLEEFST LLQKAEEHEE
5230 5240 5250 5260 5270 5280
SQGPVGTETD AINQQLDVFK IFQKEEIEPL QAKQQDVNWL GQGLIQSAAA NTCTQGLEHD
5290 5300 5310 5320 5330 5340
LDSINARWKT LNKKVAQRTS QLQEALLHCG RFQDALESLL SWMADTEELV ANQKPPSAEF
5350 5360 5370 5380 5390 5400
KVVKAQIQEQ KLLQRLLEDR KSTVEAIKRE GEKIAASAEP ADRVKLSRQL SLLDSRWEML
5410 5420 5430 5440 5450 5460
LSRAEARNRQ LEGISVVAQE FHETLEPLNE WLTAVEKKLA NSEPIGTQAP KLEEQIAQHK
5470 5480 5490 5500 5510 5520
ALQEDILLRK QSVDQALLNG LELLKQTTGD EVLIIQDKLE AIKARYKDIT KLSADVAKTL
5530 5540 5550 5560 5570 5580
EHALQLAGQL QSKHKELCNW LDRVEVELLS YETQGLKGEA ASQVQERQKE LKNEVRNNKA
5590 5600 5610 5620 5630 5640
LLDSLNEVSS ALLETGALEG KRRAXEDGRR GQRTLPIGER HHHTESGRDX CCHSEVSAVX
5650 5660 5670 5680 5690 5700
PSGRCXVILD HXNTEEINVS GLHQAGARPD LCSAAGSKGF HHGYLETQGY HXRTRYLWAX
5710 5720 5730 5740 5750 5760
NHDHIQRRGE AVNEEKTGQG SEEVRRHLPD QLREAPAAGA GAVPRXPVLG DLXGTLAVAN
5770 5780 5790 5800 5810 5820
GNTTNHLSAT GPSPGVRDSE ETARGASATA RADSGTQASH RXDEQDRAAA AGTEPQGRRP
5830 5840 5850 5860 5870 5880
YPGKVCGSRH PLQPNXRRCQ KASRGTGXGH FSVHPVSRQD RPDPXEPGAH RGASTAAAVH
5890 5900 5910 5920 5930 5940
LCRGXKDQGA DWXKQECVRG HGEAAAAVXD SEAEGRGDDR QVXGHRKRHI CQSCAGXVGP
5950 5960 5970 5980 5990 6000
NGFHLGKHPH PGGRQGSQAA GRDGTSREIL VXSHVAGCYH QRHSRFHPGP GGSRNRSLGS
6010 6020 6030 6040 6050 6060
KAAAGSSRGN KRGDXWTARG ARHGHHTGLR AHCRLWGAXX AHRQEEYRRV ELSVGFSKXS
6070 6080 6090 6100 6110 6120
LERPDXQTGR GHASRRPVPG WIAGNIRLGR YRRQXASHNV SHRNGLGDGQ AADXRAEAIX
6130 6140 6150 6160 6170 6180
VRSLPTTDRN GKTEPPSRTF AEESNRGGXQ AHRPGPADGA EIDMGQPGRA NCQQTAQTXG
6190 6200 6210 6220 6230 6240
CSLGAGSVPA RPGRAPRMAD THQGLAEXTE TCWRRPESHR DRTCXASRAP KXRPSPPVHR
6250 6260 6270 6280 6290 6300
GGRQQSRKXP HRVKXGRRSK QPPVQAQNSE SALAGYFGKD RSKEAAAGQR LAPGQRVPWX
6310 6320 6330 6340 6350 6360
NXGSATVADG HRASSPGIQT SGRSTGDSQR AAXRTYGSLH RLCHQRRDIQ EPDAEGTADA
6370 6380 6390 6400 6410 6420
RTMPQVCGNQ HXPRHNQLEG EVGIREKQTQ REEDKIGRGP ALGHGIPQFP PGLHQLAYPG
6430 6440 6450 6460 6470 6480
XANFERGFPA KSYLGHHLVP NXXTQGLCQR SEFTPXADNR ARQNWNPPEV FQSETRRRAH
6490 6500 6510 6520 6530 6540
XEPADQRAES VGKGGSALSR ERKILGRSEE EGQAVPRSLE XADGMAGRLR KIPGFXTGNR
6550 6560 6570 6580 6590 6600
QRSRQNQSTA GSAQGVSEIT RRQTFCVRHH QSDWTFSEGE NFPGRRHPEA GEHAERTQGQ
6610 6620 6630 6640 6650 6660
MGHHLWKVRG KTKQTGGSPV VFRAVHRCPA GPHXLAVSGX APAGRRPTCS RRHXLGDEPD
6670 6680 6690 6700 6710 6720
RXSQGLPERV GEEDQQRAGP EALCQGAHRR QPGXLLLGQG PDAGTKHPLG DGVRALDIKA
6730 6740 6750 6760 6770 6780
DAARISPATG RGIPLCGPHP FGVAGRGRAN AAFPWRAPRR RGCSPDSYXA TXRVHEETGR
6790 6800 6810 6820 6830 6840
EKSRTKXGHR YGGRSPDRLP PXLHYHHXAL DNHHPGQVXR GAGLGKAAPA EVSRGAGRAH
6850 6860 6870 6880 6890 6900
RXAGAAGEFA RLAAVGXNHT DRERXGSHPP GDRRGENPHC RTPDLHGRND QKTAXCXXSY
6910 6920 6930 6940 6950 6960
QDLXEEGRXP SILTVSHPRL GQGTSRKETL PSLRPVSFRV TDANRNQEPQ GXLAGEQVAA
6970 6980 6990 7000 7010 7020
GLAPGLGTKE EAQRRLGQAG GAEGIRXLRF XYLAEKIHEV DESXEVESDG FLPENRXGPG
7030 7040 7050 7060 7070 7080
WEDHSAGIHX RHSVLQVSYQ SSGDERRGRH LXQRRRWVHR LLXIRGRSTS KQRCVQTHHG
7090 7100 7110 7120 7130 7140
RXQNRRXGHE AGGQVXVRQA VPSXADRRQQ IQVLPGKSVW RLPAAATGSD PAKHRDGPCW
7150 7160 7170 7180 7190 7200
RWMDGSGXVL SEKRSVQGSS SREXNVAFGI KLFNYCYSAY SSQRKDQHGA AGEVHLSGRG
7210 7220 7230 7240 7250 7260
QPGYGCLPTT RPPISAFVER SFPQQIHFRI QSRLPGSLPT GACCRQHTQG NANPGKQAAA
7270 7280 7290 7300 7310 7320
ARVLVRERFP LRGGQRLDND RSLQSPNAVC XVQEDAQPPW KQSRKQSREQ SQQPPRQRRV
7330 7340 7350 7360 7370
RLXHFRNPVC VLRRGDRPTD TQTCAPSRFS AIHSQAFXNP HAPEEVTRQQ TRQVFEEI
References and
documentation are available.
Number of amino acids: 7378
Molecular weight: 822441.18
Theoretical pI: 5.80
Total number of negatively charged residues (Asp + Glu): 1094
Total number of positively charged residues (Arg + Lys): 922
Atom composition:
As there is at least one ambiguous position (B,Z or X) in the sequence
considered, the atomic composition cannot be computed.
Extinction coefficients:
Extinction coefficients are in units of M
-1 cm
-1, at 280 nm measured in water.
Ext. coefficient 556290
Abs 0.1% (=1 g/l) 0.676, assuming all pairs of Cys residues form cystines
Ext. coefficient 548790
Abs 0.1% (=1 g/l) 0.667, assuming all Cys residues are reduced
Estimated half-life:
The N-terminal of the sequence considered is M (Met).
The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Instability index:
The instability index (II) is computed to be 48.79
This classifies the protein as unstable.
Aliphatic index: 74.46
Grand average of hydropathicity (GRAVY): -0.732