ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MAIWEQLEVS KAHVAYACVG VFSSIFSLVS LYVKEKLYIG ESTVAGIFGL IVGPVCLNWF 

        70         80         90        100        110        120 
NPLKWGNSDS ITLEITRIVL CLQIFAVAVE LPRKYMLKHW VSVTMLLLPV MTAGWLIIGL 

       130        140        150        160        170        180 
FVWILIPGLN FSASLLISAC ITATDPILAQ SVVSGKFAQR VPGHLRNLLS AESGCNDGMA 

       190        200        210        220        230        240 
FPFLFLSMNL ILHPGNGREI VKDWICVTIL YECLFGCLLG CFIGYVGRIT IRFAEKKNII 

       250        260        270        280        290        300 
DRESFLAFYV VLAFMCAGFG SILGVDDLLV SFAAGATFAW DGWFSQKTQE SNVSTVIDLL 

       310        320        330        340        350        360 
LNYAYFIYFG AIIPWSQFNN GEIGTNVWRL IILSIVVIFL RRIPAVMILR PLIPDIKSWR 

       370        380        390        400        410        420 
EALFVGHFGP IGVGAIFAAI LARGELESTF SDEPTPLNVV PSKEESKHWQ LIACIWPITC 

       430        440        450        460        470        480 
FFIVTSIIVH GSSVAIITLG RHLNTITLTK TFTTHTTNGD NGKSSWMQRL PSLDKAGRSF 

       490        500        510        520        530        540 
SLHRMDTQMT LSGDEGEAEE GGGRKGLAGG EDEEGLNNDQ IGSVATSGIP ARPAGGMPRR 

       550        560        570        580        590        600 
RKLSRKEKRL NRRQKLRNKG REIFSSRSKN EMYDDDELND LGRERLQKEK EARAATFALS 

       610        620        630        640        650        660 
TAVNTQRNEE IGMGGDEEED EYTPEKEYSD NYNNTPSFES SERSSSLRGR TYVPRNRYDG 

       670        680        690        700        710        720 
EETESEIESE DEMENESERS MASSEERRIR KMKEEEMKPG TAYLDGNRMI IENKQGEILN 

       730        740        750        760        770        780 
QVDIEDRNEA RDDEVSVDST AHSSLTTTMT NLSSSSGGRL KRILTPTSLG KIHSLVDKGK 

       790        800        810        820        830        840 
DKNKNSKYHA FKIDNLLIIE NEDGDVIKRY KINPHKSDDD KSKNRPRNDS VVSRALTAVG 

       850        860        870        880        890        900 
LKSKANSGVP PPVDEEKAIE GPSRKGPGML KKRTLTPAPP RGVQDSLDLE DEPSSEEDLG 

       910        920        930        940        950        960 
DSYNMDDSED YDDNAYESET EFERQRRLNA LGEMTAPADQ DDEELPPLPV EAQTGNDGPG 

       970        980 
TAEGKKKQKS AAVKSALSKT LGLNK 

References and documentation are available.

Number of amino acids: 985

Molecular weight: 109369.11

Theoretical pI: 5.36

Amino acid composition: 
Ala (A)  63	  6.4%
Arg (R)  58	  5.9%
Asn (N)  49	  5.0%
Asp (D)  56	  5.7%
Cys (C)  12	  1.2%
Gln (Q)  21	  2.1%
Glu (E)  82	  8.3%
Gly (G)  78	  7.9%
His (H)  14	  1.4%
Ile (I)  69	  7.0%
Leu (L)  92	  9.3%
Lys (K)  57	  5.8%
Met (M)  23	  2.3%
Phe (F)  38	  3.9%
Pro (P)  43	  4.4%
Ser (S)  86	  8.7%
Thr (T)  52	  5.3%
Trp (W)  15	  1.5%
Tyr (Y)  22	  2.2%
Val (V)  55	  5.6%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 138
Total number of positively charged residues (Arg + Lys): 115

Atomic composition:

Carbon      C	      4832
Hydrogen    H	      7663
Nitrogen    N	      1329
Oxygen      O	      1492
Sulfur      S	        35

Formula: C4832H7663N1329O1492S35
Total number of atoms: 15351

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   116030
Abs 0.1% (=1 g/l)   1.061, assuming all pairs of Cys residues form cystines


Ext. coefficient   115280
Abs 0.1% (=1 g/l)   1.054, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 47.31
This classifies the protein as unstable.



Aliphatic index: 86.34

Grand average of hydropathicity (GRAVY): -0.324