ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MALIVASLFL PYQPQFELDT SLPENSQVDS SLVNIQAMAN DQQQQRALSN NISQESLVAP 

        70         80         90        100        110        120 
APEQGVPPAI SRSATRSPSA FNRASSTTNT ATLDDLVSSD IFMENLTANA TTSHTPTSKT 

       130        140        150        160        170        180 
MLKPRKNGSV ERFFSPSSNI PTDRIASPIQ HEHDSGSRIA SPIQQQQQDP TTNLLKNVNK 

       190        200        210        220        230        240 
SLLVHSLLNN TSQTSLEGPN NHIVTPKSRA GNRPTSAATS LVNRTKQGSA SSGSSGSSAP 

       250        260        270        280        290        300 
PSIKRITPHL TASAAKQRPL LAKQPSNLKY SELADISSSE TSSQHNESDP DDLTTAPDEE 

       310        320        330        340        350        360 
YVSDLEMDDA KQDYKVPKFG GYSNKSKLKK YALLRSSQEL FSRLPWSIVP SIKGNGAMKN 

       370        380        390        400        410        420 
AINTAVLENI IPHRHVKWVG TVGIPTDEIP ENILANISDS LKDKYDSYPV LTDDDTFKAA 

       430        440        450        460        470        480 
YKNYCKQILW PTLHYQIPDN PNSKAFEDHS WKFYRNLNQR FADAIVKIYK KGDTIWIHDY 

       490        500        510        520        530        540 
HLMLVPQMVR DVLPFAKIGF TLHVSFPSSE VFRCLAQREK ILEGLTGADF VGFQTREYAR 

       550        560        570        580        590        600 
HFLQTSNRLL MADVVHDEEL KYNGRVVSVR FTPVGIDAFD LQSQLKDGSV MQWRQLIRER 

       610        620        630        640        650        660 
WQGKKLIVCR DQFDRIRGIH KKLLAYEKFL VENPEYVEKS TLIQICIGSS KDVELERQIM 

       670        680        690        700        710        720 
IVVDRINSLS TNISISQPVV FLHQDLDFSQ YLALSSEADL FVVSSLREGM NLTCHEFIVC 

       730        740        750        760        770        780 
SEDKNAPLLL SEFTGSASLL NDGAIIINPW DTKNFSQAIL KGLEMPFDKR RPQWKKLMKD 

       790        800        810        820        830        840 
IINNDSTNWI KTSLQDIHIS WQFNQEGSKI FKLNTKTLME DYQSSKKRMF VFNIAEPPSS 

       850        860        870        880        890        900 
RMISILNDMT SKGNIVYIMN SFPKPILENL YSRVQNIGLI AENGAYVSLN GVWYNIVDQV 

       910        920        930        940        950        960 
DWRNDVAKIL EDKVERLPGS YYKINESMIK FHTENAEDQD RVASVIGDAI THINTVFDHR 

       970        980        990       1000       1010       1020 
GIHAYVYKNV VSVQQVGLSL SAAQFLFRFY NSASDPLDTS SGQITNIQTP SQQNPSDQEQ 

      1030       1040       1050       1060       1070       1080 
QPPASPTVSM NHIDFACVSG SSSPVLEPLF KLVNDEASEG QVKAGHAIVY GDATSTYAKE 

      1090 
HVNGLNELFT IISRIIED 

References and documentation are available.

Number of amino acids: 1098

Molecular weight: 123017.86

Theoretical pI: 6.17

Amino acid composition: 
Ala (A)  69	  6.3%
Arg (R)  46	  4.2%
Asn (N)  70	  6.4%
Asp (D)  68	  6.2%
Cys (C)   7	  0.6%
Gln (Q)  61	  5.6%
Glu (E)  55	  5.0%
Gly (G)  44	  4.0%
His (H)  27	  2.5%
Ile (I)  79	  7.2%
Leu (L)  94	  8.6%
Lys (K)  65	  5.9%
Met (M)  21	  1.9%
Phe (F)  43	  3.9%
Pro (P)  58	  5.3%
Ser (S) 121	 11.0%
Thr (T)  58	  5.3%
Trp (W)  13	  1.2%
Tyr (Y)  31	  2.8%
Val (V)  68	  6.2%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 123
Total number of positively charged residues (Arg + Lys): 111

Atomic composition:

Carbon      C	      5453
Hydrogen    H	      8585
Nitrogen    N	      1499
Oxygen      O	      1686
Sulfur      S	        28

Formula: C5453H8585N1499O1686S28
Total number of atoms: 17251

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   118065
Abs 0.1% (=1 g/l)   0.960, assuming all pairs of Cys residues form cystines


Ext. coefficient   117690
Abs 0.1% (=1 g/l)   0.957, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 45.27
This classifies the protein as unstable.



Aliphatic index: 85.69

Grand average of hydropathicity (GRAVY): -0.397