ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MAQLANIGEL LSMLDSSTLG VRDDVTTIFK ESLNSERGPM LVNTLVDYYL ETNSQPVLHI 

        70         80         90        100        110        120 
LTTLQEPHDK HLLDKMNEYV GKAATRLSIL SLLGHVVRLQ PSWKHKLSQA PLLPSLLKCL 

       130        140        150        160        170        180 
KMDTDVVVLT TGVLVLITML PMIPQSGKQH LLDFFDIFGR LSSWCLKKPG HVTEVYLVHL 

       190        200        210        220        230        240 
HASVYALFHR LYGMYPCNFV SFLRSHYSMK ENVETFEEVV KPMMEHVRIH PELVTGSKDH 

       250        260        270        280        290        300 
ELDPRRWKTL ETHDVVIECA KISLDPTEAS YEDGDAVSHQ LSACFPHRSA DVTTSSYVDT 

       310        320        330        340        350        360 
QNSYGGATST PSSTSRLMLF STPGQLPQSL SSLSTRPLPE PLQASLWSPS AVCGMTTPPT 

       370        380        390        400        410        420 
SPGNVPADLS HPYSKAFGTT TGGKGTPSGT PATSPPPAPP CPQDDCAHGP ASQASATPPR 

       430        440        450        460        470        480 
KEERADSSRP YLPRQQDVPS DRGLEDLPGS KGSVTLRNLP DFLGDLASEE DSIEKDKEEA 

       490        500        510        520        530        540 
AISKELSEIT TAEADPVAPR GGFDSPFYRD SLSGSQRKTH SAASGTQGFS VNPEPLHSSL 

       550        560        570        580        590        600 
DKHGPDTPKQ AFTPIDPPSG SADASPAGDR DRQTSLETSI LTPSPCKIPP QRGVSFGSGQ 

       610        620        630        640        650        660 
LPPYDHLFEV ALPKTACHFV SKKTEELLKK AKGNPEEDCV PSTSPMEVLD RLLEQGAGAH 

       670        680        690        700        710        720 
SKELSRLSLP SKSVDWTHFG GSPPSDEIRT LRDQLLLLHN QLLYERFKRQ QHALRNRRLL 

       730        740        750        760        770        780 
RKVIRAAALE EHNAAMKDQL KLQEKDIQMW KVSLQKEQAR YSQLQQQRDT MVTQLHSQIR 

       790        800        810        820        830        840 
QLQHDREEFY NQSQELQTKL EDCRSMIAEL RVELKKANSK VCHTELLLSQ VSQKLSNSES 

       850        860        870        880        890        900 
VQQQMEFLNR QLLVLGEVNE LYLEQLQSKH PDTTKEVEMM KTAYRKELEK NRSHLLQQNQ 

       910        920        930        940        950        960 
RLDASQRRVL ELESLLAKKD HLLLEQKKYL EDVKSQASGQ LLAAESRYEA QRKITRVLEL 

       970        980        990       1000       1010       1020 
EILDLYGRLE KDGRLQKLEE DRAEAAEAAE ERLDCCTDGC SDSLLGHNEE AAGHNGETRT 

      1030       1040       1050       1060       1070       1080 
SRPGGTRASC GGRVTGGSSS SSSELSTPEK PPNQRFSSRW EPTMGEPSSS IPTTVGSLPS 

      1090       1100       1110       1120       1130       1140 
SKSFLGMKTR ELFRNKSESQ CDEDGMTMSS FSETLKTELG KDSAGMENKT PPSLDAPHPS 

      1150       1160 
SPSSDSMGQL HIMDYNETHH EHS 

References and documentation are available.

Number of amino acids: 1163

Molecular weight: 129022.15

Theoretical pI: 5.90

Amino acid composition: 
Ala (A)  67	  5.8%
Arg (R)  63	  5.4%
Asn (N)  28	  2.4%
Asp (D)  65	  5.6%
Cys (C)  18	  1.5%
Gln (Q)  63	  5.4%
Glu (E)  92	  7.9%
Gly (G)  64	  5.5%
His (H)  42	  3.6%
Ile (I)  25	  2.1%
Leu (L) 140	 12.0%
Lys (K)  67	  5.8%
Met (M)  28	  2.4%
Phe (F)  27	  2.3%
Pro (P)  81	  7.0%
Ser (S) 133	 11.4%
Thr (T)  74	  6.4%
Trp (W)   7	  0.6%
Tyr (Y)  24	  2.1%
Val (V)  55	  4.7%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 157
Total number of positively charged residues (Arg + Lys): 130

Atomic composition:

Carbon      C	      5603
Hydrogen    H	      8955
Nitrogen    N	      1601
Oxygen      O	      1800
Sulfur      S	        46

Formula: C5603H8955N1601O1800S46
Total number of atoms: 18005

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    75385
Abs 0.1% (=1 g/l)   0.584, assuming all pairs of Cys residues form cystines


Ext. coefficient    74260
Abs 0.1% (=1 g/l)   0.576, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 54.73
This classifies the protein as unstable.



Aliphatic index: 74.81

Grand average of hydropathicity (GRAVY): -0.626