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ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MARKHTFPSL KRAEILECID GLGIPFTAKE LDQPTSKAVI PLYEEFLDLF MGLTRQNLEE

70 80 90 100 110 120
KVNSLQDSVE NFEIIHESLR FTVFYQILSQ FMQNICFHDF TIQDLLKPDR NRLQLILSAV

130 140 150 160 170 180
INFAKLREER LQQFDDDIQK RESLLETYTL LDAQRKDLEE KVLLSQDRKL ESEAIIKQNE

190 200 210 220 230 240
ERNEEMFQSL IEDKRLCSQV RTEYDRIRME ASELKIRYHN VDSLMASTLE EIEKLQSSIV

250 260 270 280 290 300
HSPEKLKGKI ADTSLRIQND RSQQVELDKK SKILHTKLNS LQLIEGDLNA CLKVLEECLV

310 320 330 340 350 360
ELDKLEHATV LLSTNQELCD QIEINKKKLE FRKEQLLKQL SNAQEKLEHE QHSRNQKLEA

370 380 390 400 410 420
AKQRMDNIRE EYKVITQERN KKIQETEKKN AMIEMTEQKI AGMREELESQ ISSITMEFEK

430 440
LKSHVELYIA ELLRNLRSSN S


References and documentation are available.

Number of amino acids: 441 Molecular weight: 51911.39 Theoretical pI: 5.44
Amino acid composition: 
Ala (A) 19 4.3% Arg (R) 27 6.1% Asn (N) 21 4.8% Asp (D) 23 5.2% Cys (C) 6 1.4% Gln (Q) 33 7.5% Glu (E) 58 13.2% Gly (G) 6 1.4% His (H) 10 2.3% Ile (I) 33 7.5% Leu (L) 61 13.8% Lys (K) 40 9.1% Met (M) 11 2.5% Phe (F) 15 3.4% Pro (P) 6 1.4% Ser (S) 32 7.3% Thr (T) 18 4.1% Trp (W) 0 0.0% Tyr (Y) 7 1.6% Val (V) 15 3.4% Pyl (O) 0 0.0% Sec (U) 0 0.0% (B) 0 0.0% (Z) 0 0.0% (X) 0 0.0%
Total number of negatively charged residues (Asp + Glu): 81 Total number of positively charged residues (Arg + Lys): 67 Atomic composition: Carbon C 2270 Hydrogen H 3724 Nitrogen N 636 Oxygen O 715 Sulfur S 17 Formula: C2270H3724N636O715S17 Total number of atoms: 7362 Extinction coefficients: This protein does not contain any Trp residues. Experience shows that this could result in more than 10% error in the computed extinction coefficient. Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 10805 Abs 0.1% (=1 g/l) 0.208, assuming all pairs of Cys residues form cystines Ext. coefficient 10430 Abs 0.1% (=1 g/l) 0.201, assuming all Cys residues are reduced Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo). Instability index: The instability index (II) is computed to be 57.19 This classifies the protein as unstable. Aliphatic index: 97.30 Grand average of hydropathicity (GRAVY): -0.648