ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MARNLRNRRG SDVEDASNAK VGYETQIKDE NGIIHTTTRS LRKINYAEIE KVFDFLEDDQ 

        70         80         90        100        110        120 
VMDKDETPVD VTSDEHHNNN QKGDDEDDDV DLVSPHENAR TNEELTNERN LRKRKAHDPE 

       130        140        150        160        170        180 
EDDESFHEED VDDDEEEEEA DEFEDEYLDE DSKDNNRRRR AADRKFVVPD PDDDEEYDED 

       190        200        210        220        230        240 
DEEGDRISHS ASSKRLKRAN SRRTRSSRHP ETPPPVRRAL RSRTRHSRTS NEENDDENDN 

       250        260        270        280        290        300 
SRNEALTLAD EIRELQEDSP IREKRFLRER TKPVNYKLPP PLTASNAEEF IDKNNNALSF 

       310        320        330        340        350        360 
HNPSPARRGR GGWNASQNSG PTRRLFPTGG PFGGNDVTTI FGKNTNFYNQ VPSAFSDNNN 

       370        380        390        400        410        420 
NKLILDSDSS DDEILPLGVT PKTKKENTQK KKKKKPEIAD LDPLGVDMNV NFDDIGGLDN 

       430        440        450        460        470        480 
YIDQLKEMVA LPLLYPELYQ NFNITPPRGV LFHGPPGTGK TLMARALAAS CSSDERKITF 

       490        500        510        520        530        540 
FMRKGADILS KWVGEAERQL RLLFEEAKKH QPSIIFFDEI DGLAPVRSSK QEQIHASIVS 

       550        560        570        580        590        600 
TLLALMDGMD NRGQVIVIGA TNRPDAVDPA LRRPGRFDRE FYFPLPDVKA RFKILQIQTR 

       610        620        630        640        650        660 
KWSSPLSTNF IDKLAFLTKG YGGADLRSLC TEAALISIQR SFPQIYRSND KLLVDPSKIK 

       670        680        690        700        710        720 
VKVSDFMLAL KKIVPSSARS TGSSPQPLPE LIKPLLADQL NNLKNKLDYM LNIKDTTFQR 

       730        740        750        760        770        780 
NTSLLQNFID YEEYSGEEEE HDKYGGNEDT SSFRSYEFFE SMAESQICKP RLLINGPKGN 

       790        800        810        820        830        840 
GQQYVGAAIL NYLEEFNVQN LDLASLVSES SRTIEAAVVQ SFMEAKKRQP SVVFIPNLDI 

       850        860        870        880        890        900 
WINTIPENVI LVLSGLFRSL QSNEKILLLC LAENLDISEV KNGILSDFAF DKNIFQLHKP 

       910        920        930        940        950        960 
SKENITRYFS NLIELLKTKP SDIPMKKRRV KPLPELQKVT SNAAPTNFDE NGEPLSEKVV 

       970        980        990       1000       1010       1020 
LRRKLKSFQH QDMRLKNVLK IKLSGLMDLF KNRYKRFRKP PIDDAFLVHL FEPETSNDPN 

      1030       1040       1050       1060       1070       1080 
WQPAYIKDEN MILEVSTGRK FFNMDLDIVE ERLWNGYYSE PKQFLKDIEL IYRDANTIGD 

      1090       1100       1110       1120       1130       1140 
RERVIKASEM FANAQMGIEE ISTPDFIQEC KATRQRDLER QELFLEDEEK RAAMELEAKE 

      1150       1160       1170       1180       1190       1200 
QSQENILQEP DLKDNKANEF GVAAGNQLQA QLQTTINTAS IVNNSEVPQP IDTNLYKKEI 

      1210       1220       1230       1240       1250       1260 
PAAIPSAVDK EKAVIPEDSG ANEEYTTELI QATCTSEITT DDDERARKEP KENEDSLQTQ 

      1270       1280       1290       1300       1310       1320 
VTEENFSKID ANTNNINHVK EIQSVNKPNS LHETVEKRER SPIPKEVVEP EQGKKSDKEL 

      1330       1340       1350       1360       1370 
ILTPEQIKKV SACLIEHCQN FTVSQLEDVH SSVAKIIWKS KSAWDKTGTV DEIIKFLSE 

References and documentation are available.

Number of amino acids: 1379

Molecular weight: 157406.97

Theoretical pI: 5.06

Amino acid composition: 
Ala (A)  80	  5.8%
Arg (R)  86	  6.2%
Asn (N)  97	  7.0%
Asp (D) 112	  8.1%
Cys (C)   8	  0.6%
Gln (Q)  55	  4.0%
Glu (E) 135	  9.8%
Gly (G)  53	  3.8%
His (H)  21	  1.5%
Ile (I)  84	  6.1%
Leu (L) 119	  8.6%
Lys (K) 106	  7.7%
Met (M)  20	  1.5%
Phe (F)  58	  4.2%
Pro (P)  76	  5.5%
Ser (S) 101	  7.3%
Thr (T)  67	  4.9%
Trp (W)   8	  0.6%
Tyr (Y)  27	  2.0%
Val (V)  66	  4.8%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 247
Total number of positively charged residues (Arg + Lys): 192

Atomic composition:

Carbon      C	      6886
Hydrogen    H	     10937
Nitrogen    N	      1945
Oxygen      O	      2221
Sulfur      S	        28

Formula: C6886H10937N1945O2221S28
Total number of atoms: 22017

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    84730
Abs 0.1% (=1 g/l)   0.538, assuming all pairs of Cys residues form cystines


Ext. coefficient    84230
Abs 0.1% (=1 g/l)   0.535, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 50.74
This classifies the protein as unstable.



Aliphatic index: 77.09

Grand average of hydropathicity (GRAVY): -0.801