ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MASEKPQDLM VTCTAPVNIA VIKYWGKRDE ALILPINPSL SVTLHQDQLK TTTTAAISKD 

        70         80         90        100        110        120 
FTEDRIWLNG REEDVGQPRL QACLREIRRL ARKRRSTGDG DALPLSLGYK VHVASVNNFP 

       130        140        150        160        170        180 
TAAGLASSAA GYACLAYTLA RVYGVEGDLS EVARRGSGSA CRSLYGGFVE WQMGEQADGK 

       190        200        210        220        230        240 
DSIARQIAPE WHWPQLRVLI LVVSAEKKPT GSTVGMQTSV ATSTLLKFRA ESIVPERMKE 

       250        260        270        280        290        300 
MTRCIQEQDF QAFAQLTMKD SNQFHATCLD TFPPISYLND TSRRIIQLVH RFNAHHGQTK 

       310        320        330        340        350        360 
VAYTFDAGPN AVIFTLEDTV AEFVAAVRHS FPPAANGDKF LKGLQVAPVL LSDELKTSLA 

       370        380        390        400 
TEPSPGGVQY IIATQVGPGP QVLDDPHHHL LGPDGLPQRD L 

References and documentation are available.

Number of amino acids: 401

Molecular weight: 43902.98

Theoretical pI: 6.60

Amino acid composition: 
Ala (A)  41	 10.2%
Arg (R)  24	  6.0%
Asn (N)  10	  2.5%
Asp (D)  23	  5.7%
Cys (C)   6	  1.5%
Gln (Q)  22	  5.5%
Glu (E)  20	  5.0%
Gly (G)  28	  7.0%
His (H)  11	  2.7%
Ile (I)  18	  4.5%
Leu (L)  39	  9.7%
Lys (K)  17	  4.2%
Met (M)   7	  1.7%
Phe (F)  14	  3.5%
Pro (P)  24	  6.0%
Ser (S)  26	  6.5%
Thr (T)  28	  7.0%
Trp (W)   5	  1.2%
Tyr (Y)   9	  2.2%
Val (V)  29	  7.2%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 43
Total number of positively charged residues (Arg + Lys): 41

Atomic composition:

Carbon      C	      1945
Hydrogen    H	      3083
Nitrogen    N	       549
Oxygen      O	       583
Sulfur      S	        13

Formula: C1945H3083N549O583S13
Total number of atoms: 6173

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    41285
Abs 0.1% (=1 g/l)   0.940, assuming all pairs of Cys residues form cystines


Ext. coefficient    40910
Abs 0.1% (=1 g/l)   0.932, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 43.82
This classifies the protein as unstable.



Aliphatic index: 86.63

Grand average of hydropathicity (GRAVY): -0.214