ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MAVFTPPSGN SNSTDHTHTQ DDHDKDDNDI KKFYIRPSLG LKLWGPLVPA PDNLPGLYTL 

        70         80         90        100        110        120 
ITIQSAVGFF ALWRLRRLYK LPPPRRIATG THSDLSFGEL PSEMIVNGKT KIKKDIADFP 

       130        140        150        160        170        180 
TLNRFSTTHG DIVLAPPPII PRQSRFVSVR KLLWGLFGSL LLSQSLLELT RLNFLKYDPW 

       190        200        210        220        230        240 
CDEMKSVRDK KFFNNIVKYY HEGIDPTKIK VKDAMNGTPL STNIPEVKQS VALARAQVEA 

       250        260        270        280        290        300 
QNPIIKWFGP LEYKPMSFNE YLNRMEFHLD MFEFFQNKRN IRENSIELIN SISHNPQSSS 

       310        320        330        340        350        360 
TGLEGLSESK KLHLQNVEKR LHFLASSGDS ISAPVKKRSS TTLSRGVILP HDTKGPQDID 

       370        380        390        400        410 
LDTIRSLYDP WMTLALETSL SIKFIPTTMP SHTKTPTSTD QPLPGPTPKA LTNEKTH 

References and documentation are available.

Number of amino acids: 417

Molecular weight: 47156.12

Theoretical pI: 9.33

Amino acid composition: 
Ala (A)  16	  3.8%
Arg (R)  20	  4.8%
Asn (N)  21	  5.0%
Asp (D)  25	  6.0%
Cys (C)   1	  0.2%
Gln (Q)  12	  2.9%
Glu (E)  18	  4.3%
Gly (G)  20	  4.8%
His (H)  13	  3.1%
Ile (I)  27	  6.5%
Leu (L)  47	 11.3%
Lys (K)  32	  7.7%
Met (M)   9	  2.2%
Phe (F)  20	  4.8%
Pro (P)  35	  8.4%
Ser (S)  38	  9.1%
Thr (T)  32	  7.7%
Trp (W)   6	  1.4%
Tyr (Y)   9	  2.2%
Val (V)  16	  3.8%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 43
Total number of positively charged residues (Arg + Lys): 52

Atomic composition:

Carbon      C	      2128
Hydrogen    H	      3354
Nitrogen    N	       574
Oxygen      O	       616
Sulfur      S	        10

Formula: C2128H3354N574O616S10
Total number of atoms: 6682

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    46410
Abs 0.1% (=1 g/l)   0.984, assuming all pairs of Cys residues form cystines


Ext. coefficient    46410
Abs 0.1% (=1 g/l)   0.984, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 43.61
This classifies the protein as unstable.



Aliphatic index: 84.17

Grand average of hydropathicity (GRAVY): -0.443