ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MCNTNMSVST EGAAGTSQIP ASEQETLIIF YIGQYIMTKR LYDEKQQHIV YCSNDLLGDV 

        70         80         90        100        110        120 
FGVPSFSVKE HRKIYAMIYR NLVVVSQQDS GTSPSESRCQ PEGGSDLKDP VQASQEEKPS 

       130        140        150        160        170        180 
SSDVVSRPST SSRRRAISET EENTDELPGE RQRKRHRALS FDESLGLCVL REICCERSSS 

       190        200        210        220        230        240 
SEATDTPSHQ DLDDGVSDHS ADCLDQDSVS DQFSVEFEVE SLDSEDYSLS DEGHELSDED 

       250        260        270        280        290        300 
DEVYRVTVYQ AGESDADSFE GDPEISLADY WKCTSCNEMN PPLPSHCNRC WTLRENWLPD 

       310        320        330        340        350        360 
DKGKDKVEIS EKAKLESSDQ AEEGLDVPDG KKVTEDDAKE SSAEDSEEKV AQMLLSQESD 

       370        380        390        400        410        420 
DYSQPSTSSS IVYSSQESGK ELKEDTQDKE ESMESSFSLN AIEPCVICQG RPKNGCIVHG 

       430        440        450 
KTGHLMSCFT CAKKLKKRNK PCPVCRQPIQ MIVLTYFN 

References and documentation are available.

Number of amino acids: 458

Molecular weight: 51050.92

Theoretical pI: 4.49

Amino acid composition: 
Ala (A)  19	  4.1%
Arg (R)  20	  4.4%
Asn (N)  13	  2.8%
Asp (D)  41	  9.0%
Cys (C)  18	  3.9%
Gln (Q)  24	  5.2%
Glu (E)  49	 10.7%
Gly (G)  22	  4.8%
His (H)   9	  2.0%
Ile (I)  18	  3.9%
Leu (L)  29	  6.3%
Lys (K)  27	  5.9%
Met (M)   9	  2.0%
Phe (F)  10	  2.2%
Pro (P)  21	  4.6%
Ser (S)  65	 14.2%
Thr (T)  20	  4.4%
Trp (W)   3	  0.7%
Tyr (Y)  13	  2.8%
Val (V)  28	  6.1%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 90
Total number of positively charged residues (Arg + Lys): 47

Atomic composition:

Carbon      C	      2159
Hydrogen    H	      3397
Nitrogen    N	       603
Oxygen      O	       774
Sulfur      S	        27

Formula: C2159H3397N603O774S27
Total number of atoms: 6960

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    36995
Abs 0.1% (=1 g/l)   0.725, assuming all pairs of Cys residues form cystines


Ext. coefficient    35870
Abs 0.1% (=1 g/l)   0.703, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 58.46
This classifies the protein as unstable.



Aliphatic index: 61.90

Grand average of hydropathicity (GRAVY): -0.794