ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MDKEIYCGSV PVSYFDPFDL FESLRPEFQQ ILPLDNIHWK AFDGTVRTVN RLPIELIPEG 

        70         80         90        100        110        120 
RGEADKSNDE QPFIRFLIVN CISIDQYRAK VRPLVRQWLP NLESVSSSTG EKMIYKPIIL 

       130        140        150        160        170        180 
LYANSEVVDS NLFKSVSLME KFGKDFPHVQ TLEVRSVYRS PKERQEFWNQ FSQKIKASVL 

       190        200        210        220        230        240 
SIFQKRLTHL QHSLANLQKG NNFEEQLLTR EKLYELYVVF NILEDASLEL QKIKKEILRR 

       250        260        270        280        290        300 
NMNMPDGKLQ VPFESSSKSD ESLGSIIIEG TLDKFQLHKY FFIRRLRLLK LEDQTLTAFV 

       310        320        330        340        350        360 
GAFQLIKNFI ESISIEYRKS VRLLEFKHYF ITSMLSYFEF ENVSNPLLCE IKAELLMLKR 

       370        380        390        400        410        420 
DNWVQGVMAT SGYRLMDKNY PNSDVKYKFD LLKETFVDET VFQENFLTLT KEILSLFNKC 

       430        440        450        460        470        480 
EGKRQRIVDI LSIEIGLLYY QGKKYEEAVS LFLSCYEYYT QTNWNSIGLK ILQVFIDSLS 

       490        500        510        520        530        540 
HCPKLDVLQI DGESVSASAV LTNAFLNILK LCKDNDSKEI WWKKFMDLQM KNNIHLMYPL 

       550        560        570        580        590        600 
DGLFEVTLNS KVHLARANVS AIEVNLKSYG FPEDISTKTM RLSLKNMGGD VIVFGASDFL 

       610        620        630        640        650        660 
LKKGENKLIL ECRDIMYGEF SLLSFEIIVE GITFVKEFPE NQDEFIVVPE IYCKESTKVL 

       670        680        690        700        710        720 
VKQAHNLNLG EYALELKSVQ SDALESLQVE VEVQKNIGNM KNLPVSFSMD EIQARKRYNT 

       730        740        750        760        770        780 
PFENVRLEYY LLDQITAFDL IIKTSFTKKN DQGTFGETKK VRIQCYLQLS VSVEDIFKKD 

       790        800        810        820        830        840 
IFFFKFLLNS SVREEPVILY SSELSAPDTR NDYNIRGDYI ATTPALITFD GNESFINCYE 

       850        860        870        880        890        900 
ITANNNFDSK DIFNLKVRYN TLKEQLDCFI TDAVLIEGDV EWFILFEKWK TFWELEILKK 

       910        920        930        940        950        960 
LKYDYDAFKE NRIIRLLKTS IDLNKTKSKI RNLCIEKAVL DKILICLNKV SRGIAVCNTD 

       970        980        990       1000       1010       1020 
MDEYVRNLVP KQLTVPVQLP GFEQFFHVQF EQMETSHDAL HDTIATIGNS LSYTVIVENL 

      1030       1040       1050       1060       1070       1080 
SGQWGQDVID DGGYIFEILS SNEWLIHGQK RCAIKEKRKE FEVHLIPLKK GYLNFPRVEI 

      1090       1100 
TNINGKSCRV DHSNAFESIL IF 

References and documentation are available.

Number of amino acids: 1102

Molecular weight: 128130.69

Theoretical pI: 5.73

Amino acid composition: 
Ala (A)  36	  3.3%
Arg (R)  44	  4.0%
Asn (N)  66	  6.0%
Asp (D)  61	  5.5%
Cys (C)  17	  1.5%
Gln (Q)  45	  4.1%
Glu (E)  91	  8.3%
Gly (G)  43	  3.9%
His (H)  16	  1.5%
Ile (I)  89	  8.1%
Leu (L) 128	 11.6%
Lys (K)  92	  8.3%
Met (M)  19	  1.7%
Phe (F)  72	  6.5%
Pro (P)  31	  2.8%
Ser (S)  81	  7.4%
Thr (T)  46	  4.2%
Trp (W)  12	  1.1%
Tyr (Y)  41	  3.7%
Val (V)  72	  6.5%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 152
Total number of positively charged residues (Arg + Lys): 136

Atomic composition:

Carbon      C	      5833
Hydrogen    H	      9125
Nitrogen    N	      1481
Oxygen      O	      1686
Sulfur      S	        36

Formula: C5833H9125N1481O1686S36
Total number of atoms: 18161

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   128090
Abs 0.1% (=1 g/l)   1.000, assuming all pairs of Cys residues form cystines


Ext. coefficient   127090
Abs 0.1% (=1 g/l)   0.992, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 38.09
This classifies the protein as stable.



Aliphatic index: 99.01

Grand average of hydropathicity (GRAVY): -0.202