ProtParam
User-provided sequence:
10 20 30 40 50 60
MDNVVDPWYI NPSGFAKDTQ DEEYVQHHDN VNPTIPPPDN YILNNENDDG LDNLLGMDYY
70 80 90 100 110 120
NIDDLLTQEL RDLDIPLVPS PKTGDGSSDK KNIDRTWNLG DENNKVSHYS KKSMSSHKRG
130 140 150 160 170 180
LSGTAIFGFL GHNKTLSISS LQQSILNMSK DPQPMELINE LGNHNTVKNN NDDFDHIREN
190 200 210 220 230 240
DGENSYLSQV LLKQQEELRI ALEKQKEVNE KLEKQLRDNQ IQQEKLRKVL EEQEEVAQKL
250 260 270 280 290 300
VSGATNSNSK PGSPVILKTP AMQNGRMKDN AIIVTTNSAN GGYQFPPPTL ISPRMSNTSI
310 320 330 340 350 360
NGSPSRKYHR QRYPNKSPES NGLNLFSSNS GYLRDSELLS FSPQNYNLNL DGLTYNDHNN
370 380 390 400 410 420
TSDKNNNDKK NSTGDNIFRL FEKTSPGGLS ISPRINGNSL RSPFLVGTDK SRDDRYAAGT
430 440 450 460 470 480
FTPRTQLSPI HKKRESVVST VSTISQLQDD TEPIHMRNTQ NPTLRNANAL ASSSVLPPIP
490 500 510 520 530 540
GSSNNTPIKN SLPQKHVFQH TPVKAPPKNG SNLAPLLNAP DLTDHQLEIK TPIRNNSHCE
550 560 570 580 590 600
VESYPQVPPV THDIHKSPTL HSTSPLPDEI IPRTTPMKIT KKPTTLPPGT IDQYVKELPD
610 620 630 640 650 660
KLFECLYPNC NKVFKRRYNI RSHIQTHLQD RPYSCDFPGC TKAFVRNHDL IRHKISHNAK
670 680 690 700 710 720
KYICPCGKRF NREDALMVHR SRMICTGGKK LEHSINKKLT SPKKSLLDSP HDTSPVKETI
730 740 750 760 770
ARDKDGSVLM KMEEQLRDDM RKHGLLDPPP STAAHEQNSN RTLSNETDAL
References and
documentation are available.
Number of amino acids: 770
Molecular weight: 86633.98
Theoretical pI: 8.47
Total number of negatively charged residues (Asp + Glu): 92
Total number of positively charged residues (Arg + Lys): 97
Atomic composition:
Carbon C 3755
Hydrogen H 5995
Nitrogen N 1107
Oxygen O 1203
Sulfur S 23
Formula: C
3755H
5995N
1107O
1203S
23
Total number of atoms: 12083
Extinction coefficients:
Extinction coefficients are in units of M
-1 cm
-1, at 280 nm measured in water.
Ext. coefficient 41300
Abs 0.1% (=1 g/l) 0.477, assuming all pairs of Cys residues form cystines
Ext. coefficient 40800
Abs 0.1% (=1 g/l) 0.471, assuming all Cys residues are reduced
Estimated half-life:
The N-terminal of the sequence considered is M (Met).
The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Instability index:
The instability index (II) is computed to be 53.52
This classifies the protein as unstable.
Aliphatic index: 71.01
Grand average of hydropathicity (GRAVY): -0.909