ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MDQLAENLEQ ARLQEGEEEE PLGHDLPEHM LVRNSGTEDA VQPLPQQQQT IDTTGNSQVM 

        70         80         90        100        110        120 
AASFMASKTC PYPLSVVWWK TNSGQNRAII GYSDGSICFV GLSPNCPMIA STAIENGSVM 

       130        140        150        160        170        180 
RLVICKDKAY DGVMLLITSS LKQQYKLLLE QKAIKYVYPG DSSPTTREGA WQIVMSVQDK 

       190        200        210        220        230        240 
HQSAATGARQ SNSSDPASDS SQLEEDVFAP PSSDDVVCSG PAAASSDPST VSASAEAATA 

       250        260        270        280        290        300 
DVPPPPAPPS YSEAVARQSG DQGGVRFQQQ QLPAGSMDGI LPATRARLAS LKSLGSKKLQ 

       310        320        330        340        350        360 
AIKMRLSDQR QKFDEFMPDS TMGSFAIMDS PSVTPEPLGT TSGSFYNIQN LRSTFLLSAL 

       370        380        390        400        410        420 
HSNSHSLTVH SIDISLKPLF VYKIPKHTQE ILISSNILYG IHYVDLHCRS DSDHFTAASL 

       430        440        450        460        470        480 
LDDPLVANTE KENRDADIEK IDQADVSAQK SDSTSATTTA TSSLDQSDMP STAINAVSVI 

       490        500        510        520        530        540 
SSAMASLHTS DEDRFNNLAQ LGLFRFENET VLHLYQMAQY RNPSAEPETL TKEEKAKAFE 

       550        560        570        580        590        600 
LKDIHTPMDY IQFYETADVS SEFSLRQMEI MQSEFPKINY DPSYVITNKN VYTIQLKKEP 

       610        620        630        640        650        660 
FELFLDAALQ NEFNQCRDFC NTFDLSFEQC IEFAGDYLLR RKKITQALLT YNKARVKPIR 

       670        680        690        700        710        720 
TALKLAMYGH TYALMQLSAM ALKSTYLLRS RYLGHPLLKG ILGDITYRHS EDVRVILPEK 

       730        740        750        760        770        780 
HEEEDVNSGV FCSDYHYGVD ESISALQMSP SSQFHLANLL LITLAEKAVN DKNYIPLWNF 

       790        800        810        820        830        840 
LVTNSKYHTN MTSIVLCQSG LFSSAIILAK IRGVCLDTFN ALISVVAQEF GWYNELNVCL 

       850        860        870        880        890        900 
YNLSENIFLE TITYLPHVSM DYFAFIQEKL HHIRPCVLQR LSKQLNPFSP ALRPIVSHNS 

       910        920        930        940        950        960 
DCAMSNDNNP QLFEFCKSLI ETYLAVLIHM ESQRVKYDSI VNALSNFRIN YEDNQFAIES 

       970        980        990       1000       1010       1020 
SRFKPISAGC AYCACVVDGT AYFWGSSGIP SYYSAQKSTE PPEPAHAVKS LDLLSQLNLQ 

      1030       1040       1050       1060       1070       1080 
VHAIKCGRQH TLILTNNGLY SLGNNNLCQL GIGRHMQMAL QPMLVTALDG MNITMLEAGQ 

      1090       1100       1110       1120 
YHNAAVADGK LYMWGWGIYG QLGQGSCENI ATPQLVSFFQ I 

References and documentation are available.

Number of amino acids: 1121

Molecular weight: 124395.83

Theoretical pI: 5.32

Amino acid composition: 
Ala (A)  92	  8.2%
Arg (R)  37	  3.3%
Asn (N)  56	  5.0%
Asp (D)  61	  5.4%
Cys (C)  22	  2.0%
Gln (Q)  66	  5.9%
Glu (E)  60	  5.4%
Gly (G)  52	  4.6%
His (H)  30	  2.7%
Ile (I)  64	  5.7%
Leu (L) 115	 10.3%
Lys (K)  49	  4.4%
Met (M)  33	  2.9%
Phe (F)  43	  3.8%
Pro (P)  55	  4.9%
Ser (S) 118	 10.5%
Thr (T)  59	  5.3%
Trp (W)   8	  0.7%
Tyr (Y)  44	  3.9%
Val (V)  57	  5.1%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 121
Total number of positively charged residues (Arg + Lys): 86

Atomic composition:

Carbon      C	      5500
Hydrogen    H	      8589
Nitrogen    N	      1471
Oxygen      O	      1707
Sulfur      S	        55

Formula: C5500H8589N1471O1707S55
Total number of atoms: 17322

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   110935
Abs 0.1% (=1 g/l)   0.892, assuming all pairs of Cys residues form cystines


Ext. coefficient   109560
Abs 0.1% (=1 g/l)   0.881, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 46.92
This classifies the protein as unstable.



Aliphatic index: 85.23

Grand average of hydropathicity (GRAVY): -0.218