ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MDSQLNPSKR RKISVRHRCV ACYKMFNRRE HLVEHMKISY HSLHQPRCGV CLKHCKSFES 

        70         80         90        100        110        120 
VREHLNVPDH LSKGNCKAIF TKRGCTLCLQ IFEEAFALAE HKNKCHLSPP RPLGTSTQRN 

       130        140        150        160        170        180 
PSSSLAGSRL KAMALDCEMV GGGADGTIDQ CASVCLVDDD ENVIFSTHVQ PLLPVTDYRH 

       190        200        210        220        230        240 
EITGLTKEDL KDGMPLEHVR ERVFSFLCGG QNDGAGRLLL VGHDLRHDMS CLKLEYPSHL 

       250        260        270        280        290        300 
LRDTAKYVPL MKTNLVSQSL KYLTKSYLGY KIQCGKHEVY EDCVSAMRLY KRMRDQEHVC 

       310        320        330        340 
SGKAEGNGLN SRKQSDLEKM NAEELYQKST SEYRCWCLDR LSNP 

References and documentation are available.

Number of amino acids: 344

Molecular weight: 39120.94

Theoretical pI: 8.69

Amino acid composition: 
Ala (A)  15	  4.4%
Arg (R)  24	  7.0%
Asn (N)  13	  3.8%
Asp (D)  19	  5.5%
Cys (C)  19	  5.5%
Gln (Q)  12	  3.5%
Glu (E)  22	  6.4%
Gly (G)  21	  6.1%
His (H)  18	  5.2%
Ile (I)   8	  2.3%
Leu (L)  40	 11.6%
Lys (K)  26	  7.6%
Met (M)  11	  3.2%
Phe (F)   8	  2.3%
Pro (P)  13	  3.8%
Ser (S)  29	  8.4%
Thr (T)  13	  3.8%
Trp (W)   1	  0.3%
Tyr (Y)  12	  3.5%
Val (V)  20	  5.8%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 41
Total number of positively charged residues (Arg + Lys): 50

Atomic composition:

Carbon      C	      1688
Hydrogen    H	      2708
Nitrogen    N	       504
Oxygen      O	       506
Sulfur      S	        30

Formula: C1688H2708N504O506S30
Total number of atoms: 5436

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    24505
Abs 0.1% (=1 g/l)   0.626, assuming all pairs of Cys residues form cystines


Ext. coefficient    23380
Abs 0.1% (=1 g/l)   0.598, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 42.29
This classifies the protein as unstable.



Aliphatic index: 75.64

Grand average of hydropathicity (GRAVY): -0.541