ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MEANEERCIL LKYPHPSSDI SSEYLLLELD DDLLKTLEEN PEEEIVFKSD FDKKASVLCT 

        70         80         90        100        110        120 
SDKTYAVRQV VQSNSYLLFD ELSPTDWVLN DTCYSFLEVE RIYGFIFSDD KISYWDEDSV 

       130        140        150        160        170        180 
ELKPISLTKD QFIRSVPASR NEVDSFLQKN FFMVKNEFLY RLSPSYICSI IDWIFVIAQQ 

       190        200        210        220        230        240 
LHIDFASFEF KILKKPAMDD EFDWDSVICV LESISSPIKD NVLPKKFNID LELTTFWYGR 

       250        260        270        280        290        300 
FLLEGINSIS SDEFIQLWDN RLPYPCKGLP SLNLLKVGHF SQLMLKLFRV IIFTIPQIRF 

       310        320        330        340 
SIYQEISYRE NQVGGFNLCF NLSRNGYMKN FGVSLKILPC RNQELKLLY 

References and documentation are available.

Number of amino acids: 349

Molecular weight: 40937.99

Theoretical pI: 4.75

Amino acid composition: 
Ala (A)   7	  2.0%
Arg (R)  13	  3.7%
Asn (N)  18	  5.2%
Asp (D)  26	  7.4%
Cys (C)   8	  2.3%
Gln (Q)  12	  3.4%
Glu (E)  26	  7.4%
Gly (G)   9	  2.6%
His (H)   3	  0.9%
Ile (I)  29	  8.3%
Leu (L)  44	 12.6%
Lys (K)  23	  6.6%
Met (M)   5	  1.4%
Phe (F)  27	  7.7%
Pro (P)  15	  4.3%
Ser (S)  35	 10.0%
Thr (T)   9	  2.6%
Trp (W)   6	  1.7%
Tyr (Y)  15	  4.3%
Val (V)  19	  5.4%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 52
Total number of positively charged residues (Arg + Lys): 36

Atomic composition:

Carbon      C	      1881
Hydrogen    H	      2873
Nitrogen    N	       453
Oxygen      O	       543
Sulfur      S	        13

Formula: C1881H2873N453O543S13
Total number of atoms: 5763

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    55850
Abs 0.1% (=1 g/l)   1.364, assuming all pairs of Cys residues form cystines


Ext. coefficient    55350
Abs 0.1% (=1 g/l)   1.352, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 35.18
This classifies the protein as stable.



Aliphatic index: 99.37

Grand average of hydropathicity (GRAVY): -0.104