ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MEATTTTTPD LNRGDATRKS VRLYAARKGA APAPPKLSVA PSSNQNSNHS SNNNNSSSNL 

        70         80         90        100        110        120 
PETEKEMELR QTHLANKDLD GATEDDSIVE LRRRDAQATP LPRIAVSALP TLQPHPTPKE 

       130        140        150        160        170        180 
RQKPPMPRLL STEDDAGVSF ALGSIEKHIH NVEESFKQQQ QNQQSQSSMD VMKLEIKRKQ 

       190        200        210        220        230        240 
SKRYGETENL LRPGISDMSS ENDFQYLGGR RAGELDDSNE LMLSEFQRGS DGRNSIGAYS 

       250        260        270        280        290        300 
KNSAAAANGA NAVKAKLART ASDTKNNDTV LAMRATFKQK QHLQDEKQPA VWRPAGTGPT 

       310        320        330        340        350        360 
PAARSSSSTT STSGSASRGG SSSSVVDGVA PSKLTATTIS ASKRREENLR QFEALLAQKS 

       370        380        390        400        410        420 
SHRHGASGAS GTGSNAASSK RRSDRPIVAP IPPYNSSRAE HVTSSTRHSV DPRSHSGHES 

       430        440        450        460        470        480 
RSGTASTHPP VGHHPTSRVP SVVANRSNVY SNNAAQGSPN MQMRSSAPMR WRATEEHIGK 

       490        500        510        520        530        540 
YKLIKTIGKG NFAKVKLAKH LPTGKEVAIK IIDKTQLNPG SLQKLFREVR IMKMLDHPNI 

       550        560        570        580        590        600 
VKLFQVIETE KTLYLIMEYA SGGEVFDYLV LHGRMKEKEA RVKFRQIVSA VQYCHQKRII 

       610        620        630        640        650        660 
HRDLKAENLL LDSELNIKIA DFGFSNEFTP GSKLDTFCGS PPYAAPELFQ GKKYDGPEVD 

       670        680        690        700        710        720 
VWSLGVILYT LVSGSLPFDG STLRELRERV LRGKYRIPFY MSTDCENLLR KFLVLNPAKR 

       730        740        750        760        770        780 
ASLETIMGDK WMNMGFEEDE LKPYIEPKAD LADPKRIEAL VAMGYNRSEI EASLSQVRYD 

       790        800        810        820        830        840 
DVFATYLLLG RKSTDPESDG SRSGSSLSLR NISGNDAGAN AGSASVQSPT HRGVHRSISA 

       850        860        870        880        890        900 
SSTKPSRRAS SGAETLRVGP TNAAATVAAA TGAVGAVNPS NNYNAAGSAA DRASVGSNFK 

       910        920        930        940        950        960 
RQNTIDSATI KENTARLAAQ NQRPASATQK MLTTADTTLN SPAKPRTATK YDPTNGNRTV 

       970        980        990       1000       1010       1020 
SGTSGIIPRR STTLYEKTSS TEKTNVIPAE TNSGSAAPAG KGHTKSASVS SPRPSTDGCV 

      1030       1040       1050       1060       1070       1080 
SVSNDPLGTR MASAVKSSRH FPRNVPSRST FHSGQTRARN NTALEYSGTS GASGDSSHPG 

      1090 
RMSFFSKLSS RFSKRPNQ 

References and documentation are available.

Number of amino acids: 1098

Molecular weight: 118779.61

Theoretical pI: 9.86

Amino acid composition: 
Ala (A) 108	  9.8%
Arg (R)  82	  7.5%
Asn (N)  61	  5.6%
Asp (D)  48	  4.4%
Cys (C)   4	  0.4%
Gln (Q)  38	  3.5%
Glu (E)  58	  5.3%
Gly (G)  74	  6.7%
His (H)  27	  2.5%
Ile (I)  38	  3.5%
Leu (L)  76	  6.9%
Lys (K)  68	  6.2%
Met (M)  23	  2.1%
Phe (F)  27	  2.5%
Pro (P)  65	  5.9%
Ser (S) 141	 12.8%
Thr (T)  78	  7.1%
Trp (W)   4	  0.4%
Tyr (Y)  24	  2.2%
Val (V)  54	  4.9%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 106
Total number of positively charged residues (Arg + Lys): 150

Atomic composition:

Carbon      C	      5094
Hydrogen    H	      8241
Nitrogen    N	      1569
Oxygen      O	      1653
Sulfur      S	        27

Formula: C5094H8241N1569O1653S27
Total number of atoms: 16584

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    58010
Abs 0.1% (=1 g/l)   0.488, assuming all pairs of Cys residues form cystines


Ext. coefficient    57760
Abs 0.1% (=1 g/l)   0.486, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 50.07
This classifies the protein as unstable.



Aliphatic index: 64.59

Grand average of hydropathicity (GRAVY): -0.695