ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MEDPDIKRCK LSCVATVDDV IEQVMTYITD PKDRDSASLV CRRWFKIDSE TREHVTMALC 

        70         80         90        100        110        120 
YTATPDRLSR RFPNLRSLKL KGKPRAAMFN LIPENWGGYV TPWVTEISNN LRQLKSVHFR 

       130        140        150        160        170        180 
RMIVSDLDLD RLAKARADDL ETLKLDKCSG FTTDGLLSIV THCRKIKTLL MEESSFSEKD 

       190        200        210        220        230        240 
GKWLHELAQH NTSLEVLNFY MTEFAKISPK DLETIARNCR SLVSVKVGDF EILELVGFFK 

       250        260        270        280        290        300 
AAANLEEFCG GSLNEDIGMP EKYMNLVFPR KLCRLGLSYM GPNEMPILFP FAAQIRKLDL 

       310        320        330        340        350        360 
LYALLETEDH CTLIQKCPNL EVLETRNVIG DRGLEVLAQY CKQLKRLRIE RGADEQGMED 

       370        380        390        400        410        420 
EEGLVSQRGL IALAQGCQEL EYMAVYVSDI TNESLESIGT YLKNLCDFRL VLLDREERIT 

       430        440        450        460        470        480 
DLPLDNGVRS LLIGCKKLRR FAFYLRQGGL TDLGLSYIGQ YSPNVRWMLL GYVGESDEGL 

       490        500        510        520        530        540 
MEFSRGCPNL QKLEMRGCCF SERAIAAAVT KLPSLRYLWV QGYRASMTGQ DLMQMARPYW 

       550        560        570        580        590 
NIELIPSRRV PEVNQQGEIR EMEHPAHILA YYSLAGQRTD CPTTVRVLKE PI 

References and documentation are available.

Number of amino acids: 592

Molecular weight: 67665.28

Theoretical pI: 6.06

Amino acid composition: 
Ala (A)  33	  5.6%
Arg (R)  46	  7.8%
Asn (N)  21	  3.5%
Asp (D)  34	  5.7%
Cys (C)  19	  3.2%
Gln (Q)  20	  3.4%
Glu (E)  48	  8.1%
Gly (G)  36	  6.1%
His (H)   8	  1.4%
Ile (I)  30	  5.1%
Leu (L)  79	 13.3%
Lys (K)  31	  5.2%
Met (M)  20	  3.4%
Phe (F)  20	  3.4%
Pro (P)  24	  4.1%
Ser (S)  34	  5.7%
Thr (T)  29	  4.9%
Trp (W)   7	  1.2%
Tyr (Y)  20	  3.4%
Val (V)  33	  5.6%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 82
Total number of positively charged residues (Arg + Lys): 77

Atomic composition:

Carbon      C	      2992
Hydrogen    H	      4789
Nitrogen    N	       825
Oxygen      O	       881
Sulfur      S	        39

Formula: C2992H4789N825O881S39
Total number of atoms: 9526

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    69425
Abs 0.1% (=1 g/l)   1.026, assuming all pairs of Cys residues form cystines


Ext. coefficient    68300
Abs 0.1% (=1 g/l)   1.009, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 44.22
This classifies the protein as unstable.



Aliphatic index: 93.55

Grand average of hydropathicity (GRAVY): -0.240