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ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MEESKTKRKE DRIDLKNTPP QKKSKRDSTN DETARTSLRS IMPRGYKMME NMGYKEGETL

70 80 90 100 110 120
GSNESALKEP IKVEINTKRR GIRAEKPDPS TMNDMQMSEQ RFIKRESEMK NNKRLKKIWY

130 140 150 160 170 180
RIQKVAFEMM GDSDLYNPGE DPRDFNVLWR SYVMQLNEEV AKNDLNNHSN NDNEDKNNMI

190 200 210 220 230 240
PMVNESLEAS PAIKGEKFGR PSTLIDCDTS IIGSRITKDT ELAELEELSI EKRITKLNIF

250 260 270
LRSEKYYCFF CGIKYKDEGD LYEHCPGVNE DDHK


References and documentation are available.

Number of amino acids: 274 Molecular weight: 32004.15 Theoretical pI: 6.11
Amino acid composition: 
Ala (A) 8 2.9% Arg (R) 19 6.9% Asn (N) 22 8.0% Asp (D) 20 7.3% Cys (C) 4 1.5% Gln (Q) 5 1.8% Glu (E) 31 11.3% Gly (G) 13 4.7% His (H) 3 1.1% Ile (I) 18 6.6% Leu (L) 17 6.2% Lys (K) 30 10.9% Met (M) 14 5.1% Phe (F) 7 2.6% Pro (P) 12 4.4% Ser (S) 20 7.3% Thr (T) 13 4.7% Trp (W) 2 0.7% Tyr (Y) 9 3.3% Val (V) 7 2.6% Pyl (O) 0 0.0% Sec (U) 0 0.0% (B) 0 0.0% (Z) 0 0.0% (X) 0 0.0%
Total number of negatively charged residues (Asp + Glu): 51 Total number of positively charged residues (Arg + Lys): 49 Atomic composition: Carbon C 1375 Hydrogen H 2212 Nitrogen N 396 Oxygen O 446 Sulfur S 18 Formula: C1375H2212N396O446S18 Total number of atoms: 4447 Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 24660 Abs 0.1% (=1 g/l) 0.771, assuming all pairs of Cys residues form cystines Ext. coefficient 24410 Abs 0.1% (=1 g/l) 0.763, assuming all Cys residues are reduced Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo). Instability index: The instability index (II) is computed to be 46.46 This classifies the protein as unstable. Aliphatic index: 60.15 Grand average of hydropathicity (GRAVY): -1.104