ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MEGQKSNASW ESSIIEGQLS KNLARYTLLL DKLSTLSQID KLSEVIANDY AKQSKQLNAF 

        70         80         90        100        110        120 
VQQSQSSLNK ESRKLELQRT NLTTTLTQFH ETVATISSSN ARAKAIHDDI ETVDQERALV 

       130        140        150        160        170        180 
NKTLQFVKDV RTLKNNISLA HSALETKDYL VAATAINEIR SLPDKKLIVS EFAKKVVPSS 

       190        200        210        220        230        240 
EIPEEPAILI KNWCKELTSL FQEQFMEATR TQDIKELTLM FKMFPMIGQD VLGLDLYSKY 

       250        260        270        280        290        300 
VCDIIADESR KIMSNSMENS TKFQGFFSQV LLHLFKIVST IINDHSKVIA TCYGKKHMVH 

       310        320        330        340        350        360 
VMEKVEKEAD LQASLILDIF METRKIERTI HDINEWEHSQ KNEDVNIDSN QSDIETDGET 

       370        380        390        400        410        420 
EKSSIISIHD LALLIMEFSQ ILQNWSMYSR FYSVKWNEFS DLHPHVLQPP PPIADGKFAL 

       430        440        450        460        470        480 
KLKQDKVFDE FQVFVLNHLQ RSFRNSISLE ELPSLNDLIT AVPLNDHDNI SYPVTSVLDD 

       490        500        510        520        530        540 
LILLVRKNLI SVVNTGQFKL LASFLNELVK FFQNRFLVKF MQNKFKLLQS KLASNVSLKR 

       550        560        570        580        590        600 
YIPKGEEQSA TSRSVSPPAN KFSPLSRFTF RGAAASALTN IQSNLQAVVA EDEDSILALH 

       610        620        630        640        650        660 
HYLIYLNTLY LSKVYVHRLL SIEILEDDSQ RILRDNFPFD NDAAQLQNLI INSEKLVLEQ 

       670        680        690        700        710        720 
TDKLSKWAVK YLFQNILQNR VRNLLGTVFV NSASSNSSTS NQKNVSRDYS AGSNQKNYIT 

       730        740        750        760        770        780 
SIEDFEDLSQ INSFNSKWNQ LIIPYKNILH NEAYAELLSV IVDYIVTTLE QRIWTLEFNE 

       790        800        810        820        830        840 
LGVTKLDREL SLFIGNMCGL NYNLREKFLK LTQIVLLLGL DDDNFDLTTG DIKDDFNGTF 

       850        860 
DWVINSQERI KARNMKIDRT Q 

References and documentation are available.

Number of amino acids: 861

Molecular weight: 98665.52

Theoretical pI: 5.75

Amino acid composition: 
Ala (A)  45	  5.2%
Arg (R)  32	  3.7%
Asn (N)  62	  7.2%
Asp (D)  54	  6.3%
Cys (C)   4	  0.5%
Gln (Q)  48	  5.6%
Glu (E)  56	  6.5%
Gly (G)  19	  2.2%
His (H)  18	  2.1%
Ile (I)  66	  7.7%
Leu (L) 107	 12.4%
Lys (K)  63	  7.3%
Met (M)  15	  1.7%
Phe (F)  43	  5.0%
Pro (P)  19	  2.2%
Ser (S)  84	  9.8%
Thr (T)  45	  5.2%
Trp (W)   9	  1.0%
Tyr (Y)  21	  2.4%
Val (V)  51	  5.9%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 110
Total number of positively charged residues (Arg + Lys): 95

Atomic composition:

Carbon      C	      4417
Hydrogen    H	      7019
Nitrogen    N	      1175
Oxygen      O	      1342
Sulfur      S	        19

Formula: C4417H7019N1175O1342S19
Total number of atoms: 13972

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    81040
Abs 0.1% (=1 g/l)   0.821, assuming all pairs of Cys residues form cystines


Ext. coefficient    80790
Abs 0.1% (=1 g/l)   0.819, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 41.79
This classifies the protein as unstable.



Aliphatic index: 100.77

Grand average of hydropathicity (GRAVY): -0.269