ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MEISERVRAR LAVLSGHLSE GKQDSPAIER WCTSADTSVA PLGSLKGTLT IVDERTGKNY 

        70         80         90        100        110        120 
KVPVSDDGTV KAVDFKKIVT GKEDKGLKLY DPGYLNTAPV RSSISYIDGD EGILRYRGYP 

       130        140        150        160        170        180 
IEEMAENSTF LEVAYLLMYG NLPSESQLSD WEFAVSQHSA VPQGVLDIIQ SMPHDAHPMG 

       190        200        210        220        230        240 
VLVSAMSALS IFHPDANPAL RGQDIYDSKQ VRDKQIIRII GKAPTIAAAA YLRMAGRPPV 

       250        260        270        280        290        300 
LPSGNLPYAD NFLYMLDSLG NRSYKPNPRL ARVLDILFIL HAEHEMNCST AAARHLASSG 

       310        320        330        340        350        360 
VDVYTAVAGA VGALYGPLHG GANEAVLKML SEIGTVENIP EFIEGVKNRK RKMSGFGHRV 

       370        380        390        400        410        420 
YKNYDPRAKV IKNLADEVFS IVGKDPLIEV AVALEKAALS DDYFVKRKLY PNVDFYSGLI 

       430        440        450        460        470        480 
YRAMGFPPEF FTVLFAIPRM AGYLSHWKES LDDPDTKIMR PQQVYTGVWL RHYTPVRERI 

       490        500 
VTDDSKESDK LGQVATSNAS RRRLAGSSV 

References and documentation are available.

Number of amino acids: 509

Molecular weight: 56175.23

Theoretical pI: 7.21

Amino acid composition: 
Ala (A)  47	  9.2%
Arg (R)  31	  6.1%
Asn (N)  17	  3.3%
Asp (D)  33	  6.5%
Cys (C)   2	  0.4%
Gln (Q)  11	  2.2%
Glu (E)  27	  5.3%
Gly (G)  37	  7.3%
His (H)  12	  2.4%
Ile (I)  29	  5.7%
Leu (L)  46	  9.0%
Lys (K)  29	  5.7%
Met (M)  14	  2.8%
Phe (F)  15	  2.9%
Pro (P)  30	  5.9%
Ser (S)  41	  8.1%
Thr (T)  19	  3.7%
Trp (W)   4	  0.8%
Tyr (Y)  24	  4.7%
Val (V)  41	  8.1%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 60
Total number of positively charged residues (Arg + Lys): 60

Atomic composition:

Carbon      C	      2512
Hydrogen    H	      3965
Nitrogen    N	       687
Oxygen      O	       742
Sulfur      S	        16

Formula: C2512H3965N687O742S16
Total number of atoms: 7922

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    57885
Abs 0.1% (=1 g/l)   1.030, assuming all pairs of Cys residues form cystines


Ext. coefficient    57760
Abs 0.1% (=1 g/l)   1.028, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 41.05
This classifies the protein as unstable.



Aliphatic index: 90.06

Grand average of hydropathicity (GRAVY): -0.210