ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MEISSSPWND GGYSPYERNR VAVSPFSSAL EGEERIETSR SLGDHCFEPL PYVTNYLSIF 

        70         80         90        100        110        120 
ALFGKEIFGD KGNVSSRNEY LLKKYYSLKK PFVLRHNGHA LKNPDMPLQR NDILQTNFMV 

       130        140        150        160        170        180 
DKFLNRTVRS VNFNNFKIIS DMQSKSGRGT KSGTNQNQSA DAIQNICLPS IPSALPYFQY 

       190        200        210        220        230        240 
YRKLLTVNTK EWDILKLHSL WVPKLRKDFK DFSLYGDKNS LKPIDSHYDE DNTMKKNLFF 

       250        260        270        280        290        300 
ERSPSRQTLD GKGCASKGYD ISSGNMIIPS LFSEDKLPAL TYHCSVELNG NIYIFGGLMP 

       310        320        330        340        350        360 
CYSYEEDAPM LNDFFVDGIK NLPPPLLPQV INNPSMVNNP HLYVASIPSC RFSKPKMGGY 

       370        380        390        400        410        420 
IPPPLLCVQG SKLTDRHIFF YGGFEIRTET RGDENGKYHL KKRLYVNNTG YILDIMSFKF 

       430        440        450        460        470        480 
TKIDIIVQPS KYNAYPTMSS RFGHLQISID NPNRRASVHS SSMNEIHKMG SASMKQGSSI 

       490        500        510        520        530        540 
TSGRLEKAAV LSSLPHNTVH TVIIFGGYRQ TGDDRYEAMN DLWKIEIPVI RRGKKGYCKF 

       550        560        570        580        590        600 
SETANAILLT PSEKDKSDWP EERAFSAFSV HGTSLMDRSS LDMRLLNNLK NHFVLKPSYI 

       610        620        630        640        650        660 
SQDRVVSPKP VFPMMVHGTH QDLFNSGSAA QESPKAGASA SSASAASFDP DMDDNLENYI 

       670        680        690        700        710        720 
VNPGRKSSSI PMTAIGRQRL ILSQEKPVGK TVVLHGGSNG LNVLDDMWLM DLECETWTPI 

       730        740        750        760        770        780 
ETFAKADSSE DGDEKLDSVN VGLVGHRMES IGRICVCIGG MVQEDVDQFY SENDDEPPRK 

       790        800        810        820        830        840 
RKVDTLPLGG NFLNTIDLST QCWEEHKITL SKKEDDEDRQ DSENEDTNSN IVVGVGGTSL 

       850        860        870        880 
QCDKSIILIG GLISRRSNVK EIYLHGTITK SIFPSVNPSA 

References and documentation are available.

Number of amino acids: 880

Molecular weight: 98655.74

Theoretical pI: 6.76

Amino acid composition: 
Ala (A)  33	  3.8%
Arg (R)  41	  4.7%
Asn (N)  57	  6.5%
Asp (D)  58	  6.6%
Cys (C)  13	  1.5%
Gln (Q)  24	  2.7%
Glu (E)  46	  5.2%
Gly (G)  61	  6.9%
His (H)  22	  2.5%
Ile (I)  57	  6.5%
Leu (L)  74	  8.4%
Lys (K)  60	  6.8%
Met (M)  26	  3.0%
Phe (F)  38	  4.3%
Pro (P)  51	  5.8%
Ser (S)  95	 10.8%
Thr (T)  38	  4.3%
Trp (W)   8	  0.9%
Tyr (Y)  32	  3.6%
Val (V)  46	  5.2%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 104
Total number of positively charged residues (Arg + Lys): 101

Atomic composition:

Carbon      C	      4364
Hydrogen    H	      6824
Nitrogen    N	      1196
Oxygen      O	      1335
Sulfur      S	        39

Formula: C4364H6824N1196O1335S39
Total number of atoms: 13758

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    92430
Abs 0.1% (=1 g/l)   0.937, assuming all pairs of Cys residues form cystines


Ext. coefficient    91680
Abs 0.1% (=1 g/l)   0.929, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 44.00
This classifies the protein as unstable.



Aliphatic index: 76.97

Grand average of hydropathicity (GRAVY): -0.472