ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MEKNVEILSR EIVKPSSPTP DDKRILNLSL LDILSSPMYT GALLFYAADP QNLLGFSTEE 

        70         80         90        100        110        120 
TSLKLKKSLS KTLPIFYPLA GRIIGSFVEC NDEGAVFIEA RVDHLLSEFL KCPVPESLEL 

       130        140        150        160        170        180 
LIPVEAKSRE AVTWPVLLIQ ANFFSCGGLV ITICVSHKIT DATSLAMFIR GWAESSRGLG 

       190        200        210        220        230        240 
ITLIPSFTAS EVFPKPLDEL PSKPMDRKEE VEEMSCVTKR FVFDASKIKK LRAKASRNLV 

       250        260        270        280        290        300 
KNPTRVEAVT ALFWRCVTKV SRLSSLTPRT SVLQILVNLR GKVDSLCENT IGNMLSLMIL 

       310        320        330        340        350        360 
KNEEAAIERI QDVVDEIRRA KEIFSLNCKE MSKSSSRIFE LLEEIGKVYG RGNEMDLWMS 

       370        380        390        400        410        420 
NSWCKLGLYD ADFGWGKPVW VTGRGTSHFK NLMLLIDTKD GEGIEAWITL TEEQMSLFEC 

       430 
DQELLESASL NPPVLI 

References and documentation are available.

Number of amino acids: 436

Molecular weight: 48824.80

Theoretical pI: 5.51

Amino acid composition: 
Ala (A)  24	  5.5%
Arg (R)  22	  5.0%
Asn (N)  16	  3.7%
Asp (D)  19	  4.4%
Cys (C)  10	  2.3%
Gln (Q)   6	  1.4%
Glu (E)  39	  8.9%
Gly (G)  22	  5.0%
His (H)   3	  0.7%
Ile (I)  30	  6.9%
Leu (L)  56	 12.8%
Lys (K)  30	  6.9%
Met (M)  12	  2.8%
Phe (F)  19	  4.4%
Pro (P)  21	  4.8%
Ser (S)  42	  9.6%
Thr (T)  23	  5.3%
Trp (W)   8	  1.8%
Tyr (Y)   5	  1.1%
Val (V)  29	  6.7%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 58
Total number of positively charged residues (Arg + Lys): 52

Atomic composition:

Carbon      C	      2189
Hydrogen    H	      3524
Nitrogen    N	       568
Oxygen      O	       645
Sulfur      S	        22

Formula: C2189H3524N568O645S22
Total number of atoms: 6948

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    52075
Abs 0.1% (=1 g/l)   1.067, assuming all pairs of Cys residues form cystines


Ext. coefficient    51450
Abs 0.1% (=1 g/l)   1.054, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 45.32
This classifies the protein as unstable.



Aliphatic index: 101.72

Grand average of hydropathicity (GRAVY): 0.006