ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MEKPNYFQSY NKVIGATGEQ LAPGAVPPHP VLAPSIAPGG VAGVSAANMA NIMQTPGFAN 

        70         80         90        100        110        120 
LVQQAIRTQL ENQAAQQLAV NQQFQLNGAT AVQQQLLLTP QQSLAQPIAL APQPTVVLNG 

       130        140        150        160        170        180 
VSETLKKVTE LAHRQFQSGN YVEAEKYCNL VFQSDPNNLP TLLLLSAINF QTKNLEKSMQ 

       190        200        210        220        230        240 
YSMLAIKVNN QCAEAYSNLG NYYKEKGQLQ DALENYKLAV KLKPEFIDAY INLAAALVSG 

       250        260        270        280        290        300 
GDLEQAVTAY FNALQINPDL YCVRSDLGNL LKAMGRLEEA KVCYLKAIET QPQFAVAWSN 

       310        320        330        340        350        360 
LGCVFNSQGE IWLAIHHFEK AVTLDPNFLD AYINLGNVLK EARIFDRAVS AYLRALNLSG 

       370        380        390        400        410        420 
NHAVVHGNLA CVYYEQGLID LAIDTYKKAI DLQPHFPDAY CNLANALKEK GSVVEAEQMY 

       430        440        450        460        470        480 
MKALELCPTH ADSQNNLANI KREQGKIEDA TRLYLKALEI YPEFAAAHSN LASILQQQGK 

       490        500        510        520        530        540 
LNDAILHYKE AIRIAPTFAD AYSNMGNTLK EMGDSSAAIA CYNRAIQINP AFADAHSNLA 

       550        560        570        580        590        600 
SIHKDAGNMA EAIQSYSTAL KLKPDFPDAY CNLAHCHQII CDWNDYDKRV RKLVQIVEDQ 

       610        620        630        640        650        660 
LCKKRLPSVH PHHSMLYPLS HAARIAIAAK HASLCFDKVH VQMLGKTPLI HADRFSVQNG 

       670        680        690        700        710        720 
QRLRIGYVSS DFGNHPTSHL MQSIPGMHDR SRVEVFCYAL SVNDGTNFRS KLMNESEHFV 

       730        740        750        760        770        780 
DLSQIPCNGK AAEKIAQDGI HILINMNGYT KGARNEIFAL RPAPIQVMWL GYPSTSGATF 

       790        800        810        820        830        840 
MDYIITDAVT SPLRLANAFT EKLAYMPHTF FIGDHAQMLR HLTDKVVVKD KETTERDSCL 

       850        860        870        880        890        900 
IMNTANMDPI LAKSEIKEQV LDTEVVSGPN KELVRAEMVL PVLEVPTEPI KQMIMTGQMT 

       910        920        930        940        950        960 
MNVMEDMNVQ NGLGQSQMHH KAATGEEIPN SVLLTSRAQY QLPDDAIVFC NFNQLYKIDP 

       970        980        990       1000       1010       1020 
STLDMWIKIL ENVPKSILWL LRFPYQGEEH IRKYCVERGL DPSRIVFSNV AAKEEHVRRG 

      1030       1040       1050       1060       1070       1080 
QLADVCLDTP LCNGHTTGMD ILWTGTPMVT MPLESLASRV ATSQLYALGV PELVAKTRQE 

      1090       1100       1110       1120       1130       1140 
YVSIAVRLGT DADHLANMRA KVWMARTSST LFDVKQYCHD MEDLLGQMWK RYESGMPIDH 

      1150 
ITNNTETPHG L 

References and documentation are available.

Number of amino acids: 1151

Molecular weight: 128011.70

Theoretical pI: 6.14

Amino acid composition: 
Ala (A) 121	 10.5%
Arg (R)  40	  3.5%
Asn (N)  72	  6.3%
Asp (D)  56	  4.9%
Cys (C)  22	  1.9%
Gln (Q)  68	  5.9%
Glu (E)  62	  5.4%
Gly (G)  57	  5.0%
His (H)  38	  3.3%
Ile (I)  65	  5.6%
Leu (L) 120	 10.4%
Lys (K)  61	  5.3%
Met (M)  40	  3.5%
Phe (F)  34	  3.0%
Pro (P)  55	  4.8%
Ser (S)  62	  5.4%
Thr (T)  54	  4.7%
Trp (W)   9	  0.8%
Tyr (Y)  43	  3.7%
Val (V)  72	  6.3%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 118
Total number of positively charged residues (Arg + Lys): 101

Atomic composition:

Carbon      C	      5678
Hydrogen    H	      8955
Nitrogen    N	      1557
Oxygen      O	      1687
Sulfur      S	        62

Formula: C5678H8955N1557O1687S62
Total number of atoms: 17939

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   114945
Abs 0.1% (=1 g/l)   0.898, assuming all pairs of Cys residues form cystines


Ext. coefficient   113570
Abs 0.1% (=1 g/l)   0.887, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 36.30
This classifies the protein as stable.



Aliphatic index: 91.34

Grand average of hydropathicity (GRAVY): -0.182