ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MEPEPQPEPV TLLVKSPNQR HRDLELSGDR GWSVSRLKAH LSRVYPERPR PEDQRLIYSG 

        70         80         90        100        110        120 
KLLLDHQCLQ DLLPKQEKRH VLHLVCNVRS PSKKPEASTK GAESTEQPDN TSQAQYPGDS 

       130        140        150        160        170        180 
SSDGLREREV LRNLPPSGWE NVSRPEAVQQ TFQGLGPGFS GYTTYGWLQL SWFQQIYARQ 

       190        200        210        220        230        240 
YYMQYLAATA ASGAFGPTPS AQEIPVVSTP APAPIHNQFP AENQPANQNA AAQAVVNPGA 

       250        260        270        280        290        300 
NQNLRMNAQG GPLVEEDDEI NRDWLDWTYS AATFSVFLSI LYFYSSLSRF LMVMGATVVM 

       310        320        330        340        350        360 
YLHHVGWFPF RQRPVQNFPD DGPPQEAANQ DPNNNLQGGL DPEMEDPNRL PVGREVLDPE 

       370        380        390 
HTSPSFMSTA WLVFKTFFAS LLPEGPPALA N 

References and documentation are available.

Number of amino acids: 391

Molecular weight: 43704.84

Theoretical pI: 5.26

Amino acid composition: 
Ala (A)  31	  7.9%
Arg (R)  22	  5.6%
Asn (N)  21	  5.4%
Asp (D)  18	  4.6%
Cys (C)   2	  0.5%
Gln (Q)  29	  7.4%
Glu (E)  25	  6.4%
Gly (G)  24	  6.1%
His (H)   9	  2.3%
Ile (I)   6	  1.5%
Leu (L)  38	  9.7%
Lys (K)   9	  2.3%
Met (M)   8	  2.0%
Phe (F)  16	  4.1%
Pro (P)  41	 10.5%
Ser (S)  31	  7.9%
Thr (T)  16	  4.1%
Trp (W)   8	  2.0%
Tyr (Y)  13	  3.3%
Val (V)  24	  6.1%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 43
Total number of positively charged residues (Arg + Lys): 31

Atomic composition:

Carbon      C	      1948
Hydrogen    H	      2964
Nitrogen    N	       542
Oxygen      O	       588
Sulfur      S	        10

Formula: C1948H2964N542O588S10
Total number of atoms: 6052

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    63495
Abs 0.1% (=1 g/l)   1.453, assuming all pairs of Cys residues form cystines


Ext. coefficient    63370
Abs 0.1% (=1 g/l)   1.450, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 59.56
This classifies the protein as unstable.



Aliphatic index: 69.62

Grand average of hydropathicity (GRAVY): -0.590