ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MEQNIISTIR DECIRHRSKY LTIAQLTAIA EAKINEFIIT GKAKDQDLSS LLDKCIDILS 

        70         80         90        100        110        120 
IYKKNSKDIK NIISCKNKGA MISSNSVMII QLNYVYYKVI HIIVTTNIPH LSEFAKIKLH 

       130        140        150        160        170        180 
KSTSDEGNGN NNNNEFQLMN IYNTLLETLL KDENIAKIKS FIKSSIKQTK LNHEQEECNL 

       190        200        210        220        230        240 
MRTGSYITSN QLNSLISSSA NSASSQMEIL LIDIRSRLEF NKSHIDTKNI ICLEPISFKM 

       250        260        270        280        290        300 
SYSDHDLEKK SLITSPNSEI KMFQSRNLFK FIILYTDANE YNVKQQSVLL DILVNHSFEK 

       310        320        330        340        350        360 
PISDDFTKIF ILESGFPGWL KSNYGRQVSS SFPSNNNIKD DSVYINGNTS GLSLQHLPKM 

       370        380        390        400        410        420 
SPSIRHSMDD SMKEMLVAPT PLNHLQQQQQ QQSDNDHVLK RSSSFKKLFS NYTSPNPKNS 

       430        440        450        460        470        480 
NSNLYSISSL SISSSPSPLP LHSPDPVKGN SLPINYPETP HLWKNSETDF MTNQREQLNH 

       490        500        510        520        530        540 
NSFAHIAPIN TKAITSPSRT ATPKLQRFPQ TISMNLNMNS NGHSSATSTI QPSCLSLSNN 

       550        560        570        580        590        600 
DSLDHTDVTP TSSHNYDLDF AVGLENLGNS CYMNCIIQCI LGTHELTQIF LDDSYAKHIN 

       610        620        630        640        650        660 
INSKLGSKGI LAKYFARLVH MMYKEQVDGS KKISISPIKF KLACGSVNSL FKTASQQDCQ 

       670        680        690        700        710        720 
EFCQFLLDGL HEDLNQCGSN PPLKELSQEA EARREKLSLR IASSIEWERF LTTDFSVIVD 

       730        740        750        760        770        780 
LFQGQYASRL KCKVCSHTST TYQPFTVLSI PIPKKNSRNN ITIEDCFREF TKCENLEVDE 

       790        800        810        820        830        840 
QWLCPHCEKR QPSTKQLTIT RLPRNLIVHL KRFDNLLNKN NDFVIYPFLL DLTPFWANDF 

       850        860        870        880        890        900 
DGVFPPGVND DELPIRGQIP PFKYELYGVA CHFGTLYGGH YTAYVKKGLK KGWLYFDDTK 

       910        920 
YKPVKNKADA INSNAYVLFY HRVYGV 

References and documentation are available.

Number of amino acids: 926

Molecular weight: 105191.68

Theoretical pI: 8.44

Amino acid composition: 
Ala (A)  33	  3.6%
Arg (R)  27	  2.9%
Asn (N)  78	  8.4%
Asp (D)  49	  5.3%
Cys (C)  20	  2.2%
Gln (Q)  42	  4.5%
Glu (E)  43	  4.6%
Gly (G)  32	  3.5%
His (H)  29	  3.1%
Ile (I)  79	  8.5%
Leu (L)  91	  9.8%
Lys (K)  73	  7.9%
Met (M)  18	  1.9%
Phe (F)  42	  4.5%
Pro (P)  43	  4.6%
Ser (S) 106	 11.4%
Thr (T)  50	  5.4%
Trp (W)   6	  0.6%
Tyr (Y)  33	  3.6%
Val (V)  32	  3.5%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 92
Total number of positively charged residues (Arg + Lys): 100

Atomic composition:

Carbon      C	      4674
Hydrogen    H	      7352
Nitrogen    N	      1264
Oxygen      O	      1420
Sulfur      S	        38

Formula: C4674H7352N1264O1420S38
Total number of atoms: 14748

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    83420
Abs 0.1% (=1 g/l)   0.793, assuming all pairs of Cys residues form cystines


Ext. coefficient    82170
Abs 0.1% (=1 g/l)   0.781, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 48.68
This classifies the protein as unstable.



Aliphatic index: 85.18

Grand average of hydropathicity (GRAVY): -0.425