ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MESQQLHQNP HSLHGSAAAS VTSKEVPSNQ DPLAVSASNL PEFDRDSTKV NSQQETTPGT 

        70         80         90        100        110        120 
SAVPENHHHV SPQPASVPPP QNGQYQQHGM MTPNKAMASN WAHYQQPSMM TCSHYQTSPA 

       130        140        150        160        170        180 
YYQPDPHYPL PQYIPPLSTS SPDPIDSQNQ HSEVPQAKTK VRNNVLPPHT LTSEENFSTW 

       190        200        210        220        230        240 
VKFYIRFLKN SNLGDIIPND QGEIKRQMTY EEHAYIYNTF QAFAPFHLLP TWVKQILEIN 

       250        260        270        280        290        300 
YADILTVLCK SVSKMQTNNQ ELKDWIALAN LEYDGSTSAD TFEITVSTII QRLKENNINV 

       310        320        330        340        350        360 
SDRLACQLIL KGLSGDFKYL RNQYRTKTNM KLSQLFAEIQ LIYDENKIMN LNKPSQYKQH 

       370        380        390        400        410        420 
SEYKNVSRTS PNTTNTKVTS RNYHRTNSSK PRAAKAHNIA TSSKFSRVNN DHINESTVSS 

       430 
QYLSDDNELS LRPATERI 

References and documentation are available.

Number of amino acids: 438

Molecular weight: 49724.34

Theoretical pI: 7.32

Amino acid composition: 
Ala (A)  26	  5.9%
Arg (R)  15	  3.4%
Asn (N)  38	  8.7%
Asp (D)  18	  4.1%
Cys (C)   3	  0.7%
Gln (Q)  33	  7.5%
Glu (E)  22	  5.0%
Gly (G)   9	  2.1%
His (H)  18	  4.1%
Ile (I)  22	  5.0%
Leu (L)  31	  7.1%
Lys (K)  25	  5.7%
Met (M)  10	  2.3%
Phe (F)  11	  2.5%
Pro (P)  32	  7.3%
Ser (S)  48	 11.0%
Thr (T)  33	  7.5%
Trp (W)   4	  0.9%
Tyr (Y)  20	  4.6%
Val (V)  20	  4.6%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 40
Total number of positively charged residues (Arg + Lys): 40

Atomic composition:

Carbon      C	      2179
Hydrogen    H	      3383
Nitrogen    N	       619
Oxygen      O	       691
Sulfur      S	        13

Formula: C2179H3383N619O691S13
Total number of atoms: 6885

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    51925
Abs 0.1% (=1 g/l)   1.044, assuming all pairs of Cys residues form cystines


Ext. coefficient    51800
Abs 0.1% (=1 g/l)   1.042, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 48.29
This classifies the protein as unstable.



Aliphatic index: 66.37

Grand average of hydropathicity (GRAVY): -0.804