ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MESQQLSNYP HISHGSACAS VTSKEVHTNQ DPLDVSASKI QEYDKASTKA NSQQTTTPAS 

        70         80         90        100        110        120 
SAVPENPHHA SPQPASVPPP QNGPYPQQCM MTQNQANPSG WSFYGHPSMI PYTPYQMSPM 

       130        140        150        160        170        180 
YFPPGPQSQF PQYPSSVGTP LSTPSPESGN TFTDSSSADS DMTSTKKYVR PPPMLTSPND 

       190        200        210        220        230        240 
FPNWVKTYIK FLQNSNLGGI IPTVNGKPVR QITDDELTFL YNTFQIFAPS QFLPTWVKDI 

       250        260        270        280        290        300 
LSVDYTDIMK ILSKSIEKMQ SDTQEANDIV TLANLQYNGS TPADAFETKV TNIIDRLNNN 

       310        320        330        340        350        360 
GIHINNKVAC QLIMRGLSGE YKFLRYTRHR HLNMTVAELF LDIHAIYEEQ QGSRNSKPNY 

       370        380        390        400        410        420 
RRNRSDEKND SRSYTNTTKP KVIARNPQKT NNSKSKTARA HNVSTSINSP STDNDSISKS 

       430        440        450        460        470        480 
TTEPIQLNNK HDLHLRPETY IYSKSYSFTP WTPPSRFRSI TNPYKICSSH TLSIISHKRS 

       490        500        510        520        530        540 
CSKKKYTNRY WPTISLPGQH QNINKGIAHS HSLLTQFEIG CSRYHSMLYQ KRLRTIRHCT 

       550        560        570        580        590        600 
CTYRKIWRLL LGIKVLASIK YLRTHHQCPY KKYTQISLSF HSSNACACQC TDNSILTKHH 

       610        620        630        640        650        660 
HVFRIRCRLV CYLSMSLFNR QKHQTQTYQR FTTKIPKFIR TLSIPTYHIW SSSQPTKCTI 

       670        680        690        700        710        720 
LFHLIYDNKI PLGLSITRPS RGLYPRCFYY DTSFYKPVSG QCLGYTNGPW FVYQNSPIPK 

       730        740        750        760        770        780 
KWYNSMLYNH SGFPSTWSRT AKPYLIRLPY STAMWFTEPF MVLCNRIFYY CEKFTSFTKQ 

       790        800        810        820        830        840 
KICKTTCWLG RTYQYFVTFR STCYRQSQPL QNTSSWHPRL RSTSVSKLLW IYHLSSILKE 

       850        860        870        880        890        900 
DSRYNLCYSS GQGLQIRSIQ LRRTHFRRLK PFNCFISIVH CVKDPTIQSH RIRPLSIYTI 

       910        920        930        940        950        960 
SATEKCPFKS CESNRFHTPV NSYRFETCFN QYSRTQRSPQ HIIYSSIEEI HPPNFRYREY 

       970        980        990       1000       1010       1020 
RFGWYAIRCS FTCSHVPIHT VVVRQIRFQT LRLVQKDSYK RTNIQYGWYQ QQNCSADKPR 

      1030       1040       1050       1060       1070       1080 
DEKDYTPFTF NRCFSTGKFI AQYCSYQNAN YCFTEYRGIY HRSPTPSTSR ISYRIPPIRT 

      1090       1100       1110       1120       1130       1140 
PTDKFSSNFQ FGWYWLCLYY YQQEKIIRRN NGITRHMEYE YAFRTSEIEE TNSPDCSCKS 

      1150       1160       1170       1180       1190       1200 
SKINQTNTDN FKIRGNHLRY RKGKIYRSIP QRSQPTIENE YLGHQILQKR NRPKSNKLNV 

      1210       1220       1230       1240       1250       1260 
YLQQETRNSS ICCKRHSASY VRYRYAIQHC TSLCVDDIPV TCIRQLLYYT IRHIFGIFVC 

      1270       1280       1290       1300       1310       1320 
RHQRRIIHKT STTFRNEVDT FEEITLWIET KWSELVRNYQ IIPDKTVWYG RSSWMVMRIE 

      1330       1340       1350       1360       1370       1380 
SSNNLLIRYD IVQQRLKCKE NHNNTQETIR YKDNKSGKRN SVRHTWLRNQ ISKRIHEIRY 

      1390       1400       1410       1420       1430       1440 
GKILDRKITQ TKRTFEPKRK ETSSRSTRSL YRPGTRNRRI QRESANAKVD WSSFICWIII 

      1450       1460       1470       1480       1490       1500 
LTILHQHTCS TYTIPLASFR HDIVNTIHVG HRTINMAQKQ TYQARTSRNK CFIWPTILQV 

      1510       1520       1530       1540       1550       1560 
TNWHFPTQRK SDWRKVDKGF VNMHFNYRSR NTRSQSYSAI EPQSPCARTQ ETNYRLTYIN 

      1570       1580       1590       1600       1610 
DQYNVYKREI KQIFWHKGNE TRSIRFIRIL HRDQEEHCCD DKTSSDKNIT INKQMDSL 

References and documentation are available.

Number of amino acids: 1618

Molecular weight: 190675.60

Theoretical pI: 9.80

Amino acid composition: 
Ala (A)  43	  2.7%
Arg (R) 128	  7.9%
Asn (N) 100	  6.2%
Asp (D)  51	  3.2%
Cys (C)  50	  3.1%
Gln (Q)  96	  5.9%
Glu (E)  55	  3.4%
Gly (G)  45	  2.8%
His (H)  62	  3.8%
Ile (I) 128	  7.9%
Leu (L)  89	  5.5%
Lys (K) 100	  6.2%
Met (M)  23	  1.4%
Phe (F)  67	  4.1%
Pro (P)  93	  5.7%
Ser (S) 169	 10.4%
Thr (T) 140	  8.7%
Trp (W)  29	  1.8%
Tyr (Y)  98	  6.1%
Val (V)  52	  3.2%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 106
Total number of positively charged residues (Arg + Lys): 228

Atomic composition:

Carbon      C	      8481
Hydrogen    H	     13093
Nitrogen    N	      2451
Oxygen      O	      2434
Sulfur      S	        73

Formula: C8481H13093N2451O2434S73
Total number of atoms: 26532

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   308645
Abs 0.1% (=1 g/l)   1.619, assuming all pairs of Cys residues form cystines


Ext. coefficient   305520
Abs 0.1% (=1 g/l)   1.602, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 50.84
This classifies the protein as unstable.



Aliphatic index: 64.28

Grand average of hydropathicity (GRAVY): -0.747