ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MESQQLSQHS PISHGSACAS VTSKEVHTNQ DPLDVSASKT EECEKASTKA NSQQTTTPAS 

        70         80         90        100        110        120 
SAVPENPHHA SPQPASVPPP QNGPYPQQCM MTQNQANPSG WSFYGHPSMI PYTPYQMSPM 

       130        140        150        160        170        180 
YFPPGPQSQF PQYPSSVGTP LSTPSPESGN TFTDSSSADS DMTSTKKYVR PPPMLTSPND 

       190        200        210        220        230        240 
FPNWVKTYIK FLQNSNLGGI IPTVNGKPVR QITDDELTFL YNTFQIFAPS QFLPTWVKDI 

       250        260        270        280        290        300 
LSVDYTDIMK ILSKSIEKMQ SDTQEANDIV TLANLQYNGS TPADAFETKV TNIIDRLNNN 

       310        320        330        340        350        360 
GIHINNKVAC QLIMRGLSGE YKFLRYTRHR HLNMTVAELF LDIHAIYEEQ QGSRNSKPNY 

       370        380        390        400        410        420 
RRNLSDEKND SRSYTNTTKP KVIARNPQKT NNSKSKTARA HNVSTSNNSP STDNDSISKS 

       430        440        450        460        470        480 
TTEPIQLNNK HDLHLRPGTY IYGKSHSFTP WTPPSRFRSI TNPYKICSSH TLSIISHKRS 

       490        500        510        520        530        540 
CSKKKYTNRY WPTISLPGQH QNINKGIAHS HSLLTQFEIG CSRYHSMLYQ KRLRTIRHCT 

       550        560        570        580        590        600 
CTYRKIWRLL LGIKVLASIK YLRTHHQCPY KKYTQISLSF HSSNACTCQC TDNSILTKHH 

       610        620        630        640        650        660 
HVFRIRCRLV CYLSMSLFNR QKHQTQTYQR FTTKIPKFIR TLSIPTYHIW SSSQPTKKCT 

       670        680        690        700        710        720 
ILFHLIYDNK IPLGLSITRP SRGLYPRCFY YDTSFYEPVS GQCLGYTNGP WFVYQNSPIP 

       730        740        750        760        770        780 
KKWYNSMLYN HSGFPSTWSR TAQPYLIRLP YSTAMWFTEP FMVLCNRIFY YCEKFTSFTK 

       790        800        810        820        830        840 
QKICKTTCWL GRTYQYFVTF RSTCYRQSQP LQNTSSWHPR LRSTSVSKLL WIYHLSSILK 

       850        860        870        880        890        900 
EDSRYNLCYS SGQGIQIRSI QLRRTHFRRL KPFNCFISIV HCVKDPTIRS HRIPLPIHRT 

       910        920        930        940        950        960 
TSATEKCPFK SCESNRFHTS VNSYRFETCF NQYSRTQRSP QHIIYSSIKE EIHPPNFQYR 

       970        980        990       1000       1010       1020 
EYRFGWYAIK CSFTCSHVPI HTVVARQIRF QTLRLVQKDS YKRTNIQYGW YQQQNCSADK 

      1030       1040       1050       1060       1070       1080 
PRDEKDYTPF TFNRCFSTGK FIAQYCSYQN ANYCFTEYRG IYHRSPTPST SRISYRIPPI 

      1090       1100       1110       1120       1130       1140 
RTPTDKFSSN FQFGWYWLCL YYYQQEKIIR RNNGITRHME YEYAFRTSEI EETNSPDCSC 

      1150       1160       1170       1180       1190       1200 
KSSKINQTNT DNLTIRGNHL RYRKRKIYRG IPQRSQSTVE DENLGHRILQ KRNRPKSNKL 

      1210       1220       1230       1240       1250       1260 
NVYLQQETRY SSICCKRYSA SHLRLRHAIQ YRTSLCINDI PVTCIRQLLY YTIRHIFGIF 

      1270       1280       1290       1300       1310       1320 
VCRHQRRIIH KTSTTFRNEV DTFEEITLWI ETKWSELVRN YQIIPDKTVW YGRSSWMVMR 

      1330       1340       1350       1360       1370       1380 
IESSNNMFIC RHDFIQQRLK CKENHNNTQE TIRYKDNKSG KRNSVRHTWL RNQISKRIHE 

      1390       1400       1410       1420       1430       1440 
IRYGKLINEN TQIKRTFESK RKKTRSRSTR SLYRPGTRNR RIQREGTNAK VDWSSFICWI 

      1450       1460       1470       1480       1490       1500 
IILTILHQHT CSTYTIPLAS FRHDIVDTIH VGHRTTDMAQ KQTYRARTSR NKCFVWQPTV 

      1510       1520       1530       1540       1550       1560 
LITNWQHIFT WKGNWRKVHQ GFINMYFNYG SRNTRDKICP IIKSKLPDTR TQETNYRLTY 

      1570       1580       1590       1600       1610 
INDQYNVYKR EIKQIFWHKG NETRSIRFIR ILHRDQEEHC CDDKTSSDKN ITINQMDSL 

References and documentation are available.

Number of amino acids: 1619

Molecular weight: 190671.65

Theoretical pI: 9.81

Amino acid composition: 
Ala (A)  40	  2.5%
Arg (R) 128	  7.9%
Asn (N) 101	  6.2%
Asp (D)  51	  3.2%
Cys (C)  51	  3.2%
Gln (Q)  94	  5.8%
Glu (E)  56	  3.5%
Gly (G)  50	  3.1%
His (H)  65	  4.0%
Ile (I) 128	  7.9%
Leu (L)  91	  5.6%
Lys (K) 101	  6.2%
Met (M)  24	  1.5%
Phe (F)  68	  4.2%
Pro (P)  90	  5.6%
Ser (S) 164	 10.1%
Thr (T) 146	  9.0%
Trp (W)  30	  1.9%
Tyr (Y)  92	  5.7%
Val (V)  49	  3.0%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 107
Total number of positively charged residues (Arg + Lys): 229

Atomic composition:

Carbon      C	      8470
Hydrogen    H	     13093
Nitrogen    N	      2459
Oxygen      O	      2431
Sulfur      S	        75

Formula: C8470H13093N2459O2431S75
Total number of atoms: 26528

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   305205
Abs 0.1% (=1 g/l)   1.601, assuming all pairs of Cys residues form cystines


Ext. coefficient   302080
Abs 0.1% (=1 g/l)   1.584, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 47.42
This classifies the protein as unstable.



Aliphatic index: 64.00

Grand average of hydropathicity (GRAVY): -0.751