ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MFASKKERKV HYSIRKFSIG VASVVVASLF MGSVVHATER GGSTPVATSS NKANKSQTEH 

        70         80         90        100        110        120 
MKAAEQVDEY VNKMIQLDKR KHTQNLALNI KLSAIKTKYL RELNVLEKKS KKEELTSKTK 

       130        140        150        160        170        180 
KEIDAAFEQF KKDTLKPGEK VEEAQKKVEE AEKKAKDQKE EDRRNYPTIT YKTLELEIAE 

       190        200        210        220        230        240 
SDVEVKKAEL ELVKVKAKGS RNEEKIKKAK AEVESKKAEA TKLEEIKTER KKAEEEAKRK 

       250        260        270        280        290        300 
AEAEEEVKDK LKKRTKRGAL GEPATPDKKE NDAKSSDSSV GEETLPSPSL KPEKKVAEAE 

       310        320        330        340        350        360 
KKVAEAEKKA KDQKEEDRRN YPTNTYKTLE LEIAESDVKV KEAELELVKE EAKEPQNEEK 

       370        380        390        400        410        420 
IKQAKAKVES KKAEATRLEK IKTDRKKAEE AKRKVAEEDK VKEKPAEQPQ PAPAEKPAPA 

       430        440        450        460        470        480 
PQPEKPAEQP KAEKPADQQA EEDYARRSEE EYNRLTQQQP PKTEKPAQPS TPKTGWKQEN 

       490        500        510        520        530        540 
GMWYFYNTDG SMATGWLQNN GSWYYLNSNG AMATGWLQNN GSWYYLNANG SMATGWLQNN 

       550        560        570        580        590        600 
GSWYYLNANG SMATGWLQYN GSWYYLNANG SMATGWLQNN GSWYYLNANG SMATGWLQYN 

       610        620        630        640        650        660 
GSWYYLNANG DMATGWLQYN GSWYYLNANG DMATGWLQNN GSWYYLNANG DMATGWLQYN 

       670        680        690        700        710        720 
GSWYYLNANG DMATGWLQYN GSWYYLNANG SMATDWVKDG DTWYYLEASG AMKASQWFKV 

       730        740        750 
SDKWYYVNGS GALAVNTTVD SYRVNANGEW VN 

References and documentation are available.

Number of amino acids: 752

Molecular weight: 85321.16

Theoretical pI: 8.58

Amino acid composition: 
Ala (A)  82	 10.9%
Arg (R)  21	  2.8%
Asn (N)  55	  7.3%
Asp (D)  28	  3.7%
Cys (C)   0	  0.0%
Gln (Q)  32	  4.3%
Glu (E)  84	 11.2%
Gly (G)  47	  6.2%
His (H)   4	  0.5%
Ile (I)  13	  1.7%
Leu (L)  47	  6.2%
Lys (K)  97	 12.9%
Met (M)  17	  2.3%
Phe (F)   7	  0.9%
Pro (P)  26	  3.5%
Ser (S)  48	  6.4%
Thr (T)  41	  5.5%
Trp (W)  27	  3.6%
Tyr (Y)  41	  5.5%
Val (V)  35	  4.7%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 112
Total number of positively charged residues (Arg + Lys): 118

Atomic composition:

Carbon      C	      3771
Hydrogen    H	      5850
Nitrogen    N	      1034
Oxygen      O	      1194
Sulfur      S	        17

Formula: C3771H5850N1034O1194S17
Total number of atoms: 11866

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient   209590
Abs 0.1% (=1 g/l)   2.456

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 41.01
This classifies the protein as unstable.



Aliphatic index: 55.52

Grand average of hydropathicity (GRAVY): -1.069