ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MFTSQRQLRQ NGSPMSSSRS SQHSSGTASP ISDSPASNRS YGRDLRGLMG IDIPANEPAF 

        70         80         90        100        110        120 
NRANSSDTIY FRPKKIYKME HEHPSRSTLV QLQTRSQPDD VASSQVNPEG GTDDLELGDP 

       130        140        150        160        170        180 
CGNQSLYTIG AEYVPDLDFT KLVNEWQKST EDLYEFRSSA TPQVQIKDSG KGNYELWSSP 

       190        200        210        220        230        240 
DAILTQNKLR RDSFSQENSD SLSPEDSILS RNLHSKVKPI PLPRNSQQIF TPLSNLEAER 

       250        260        270        280        290        300 
RSSYTTSSNN NSITQNNKFS FAKLKYSLPT QSSAVPASFD SNASSLNFLP TTTLSTLSEL 

       310        320        330        340        350        360 
QISPNDMMDL IQKLPRNFLN LPYTQRKKVI IEHAPSHDYK AMMSLVKKFM LTSSRSNFSL 

       370        380        390        400        410        420 
AGFANNASVS QATANDDNIN SRNTPNNSND TYVNTRPLQR SRHGSIASQF LSSFSPSMTS 

       430        440        450        460        470        480 
IAKMNSNPLS GSAGGSARPD DKGMEILGHR LGKIIGFGAW GIIRECFDIE TGVGRVIKIV 

       490        500        510        520        530        540 
KFKGHQNIKK HVLREVAIWR TLKHNRILPL LDWKLDDNYA MYCLTERIND GTLYDLVISW 

       550        560        570        580        590        600 
DEFKRSKIPF AERCRLTIFL SLQLLSALKY MHSKTIVHGD IKLENCLLQK EGKKSDWKVF 

       610        620        630        640        650        660 
LCDFGMSCHF DEKHVYRNDT FDENLSSGNS HRKRKSIEQT NLIKYPTTNF LPDDRTNDFD 

       670        680        690        700        710        720 
ASENLKYQFE NRKHQPFTPK GMVSSSSHSL KHLNQPSSSS SSNLFHKPAS QPQPQHRSPF 

       730        740        750        760        770        780 
HGRHKTTDFS NLEPEPSKYI GSLPYASPEL LRYSDARRSK SVEMHIYDSP DSSQSEISAA 

       790        800        810        820        830        840 
SSSSSNLSSL SSSTKASAVT NSGVTTSSPS GSSTDFPCIV SPLGPASDIW ALGVMLYTML 

       850        860        870        880        890        900 
VGKLPFNHEF EPRLRSLIKV GEFDRFSLAQ VCKFDRKKNE GTIGQGLYDT VIGCLTIDLD 

       910        920 
KRWKLKRIEE VLQNEMNLSE AIHDNNGS 

References and documentation are available.

Number of amino acids: 928

Molecular weight: 103956.49

Theoretical pI: 8.92

Amino acid composition: 
Ala (A)  42	  4.5%
Arg (R)  51	  5.5%
Asn (N)  61	  6.6%
Asp (D)  55	  5.9%
Cys (C)  10	  1.1%
Gln (Q)  38	  4.1%
Glu (E)  43	  4.6%
Gly (G)  45	  4.8%
His (H)  26	  2.8%
Ile (I)  49	  5.3%
Leu (L)  85	  9.2%
Lys (K)  59	  6.4%
Met (M)  20	  2.2%
Phe (F)  40	  4.3%
Pro (P)  52	  5.6%
Ser (S) 136	 14.7%
Thr (T)  50	  5.4%
Trp (W)   9	  1.0%
Tyr (Y)  25	  2.7%
Val (V)  32	  3.4%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 98
Total number of positively charged residues (Arg + Lys): 110

Atomic composition:

Carbon      C	      4547
Hydrogen    H	      7156
Nitrogen    N	      1300
Oxygen      O	      1435
Sulfur      S	        30

Formula: C4547H7156N1300O1435S30
Total number of atoms: 14468

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    87375
Abs 0.1% (=1 g/l)   0.840, assuming all pairs of Cys residues form cystines


Ext. coefficient    86750
Abs 0.1% (=1 g/l)   0.834, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 57.47
This classifies the protein as unstable.



Aliphatic index: 70.84

Grand average of hydropathicity (GRAVY): -0.635