ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MGNRSLTEAD HALLSKPLVP TSAEHTQTQE YPRPFVDGSN SQSGSELQAS PQGQFGEKAL 

        70         80         90        100        110        120 
TSTNRFIPLA NDDPGMQHEM GLDPSMRRRR EEWAERGAAK IVKDVVDPAT GELTKHVVKM 

       130        140        150        160        170        180 
GIKDFKFGEQ LGDGSYSSVV LATARDSGKK YAVKVLSKEY LIRQKKVKYV TVEKLALQKL 

       190        200        210        220        230        240 
NGTKGIFKLF FTFQDEASLY FLLEYAPHGD FLGLIKKYGS LNETCARYYA SQIIDAVDSL 

       250        260        270        280        290        300 
HNIGIIHRDI KPENILLDKN MKVKLTDFGT AKILPEEPSN TADGKPYFDL YAKSKSFVGT 

       310        320        330        340        350        360 
AEYVSPELLN DNYTDSRCDI WAFGCILYQM LAGKPPFKAA NEYLTFQKVM KIQYAFTAGF 

       370        380        390        400        410        420 
PQIVKDLVKK LLVRDPNDRL TIKQIKAHLF FHEVNFEDGS VWDDNPPEIQ PYKINAEAMK 

       430        440        450        460        470        480 
PLQKVSESDT TVKMANLQLA GNGHADTPLQ APAATSQEHS VISMTAATAA FNKDYTSQPK 

       490        500        510        520        530        540 
LGSKSSTSVR SASNNTDREV IQKKVSKNRA SVSSPSISTT SRGKDNRSRS SDAFWSRYLQ 

       550        560        570        580        590        600 
NMDERVLLMK EVALSTRNLE DSPVGLENVA LDYKNPLDIE PPTDSAGKFY KKMFLITNLG 

       610        620        630        640        650        660 
RALVFVKRRS LSMWEEQEFE LQFELELNDV EKIRFISDQV LEIDGSRTIF IGCKERAVLM 

       670        680        690        700        710        720 
KLWKLIHNGM TAKPKVVSPK SDHKMFDKFI LQKRQNTKKK NQAPPVPQSN RLINGLPDRC 

       730        740        750        760 
ILKTPEEGAL HTKRPTSLQT RSSSNYSKLL ARSTQMRKNM TRTDEK 

References and documentation are available.

Number of amino acids: 766

Molecular weight: 86252.52

Theoretical pI: 9.26

Amino acid composition: 
Ala (A)  54	  7.0%
Arg (R)  38	  5.0%
Asn (N)  37	  4.8%
Asp (D)  46	  6.0%
Cys (C)   5	  0.7%
Gln (Q)  34	  4.4%
Glu (E)  46	  6.0%
Gly (G)  39	  5.1%
His (H)  14	  1.8%
Ile (I)  36	  4.7%
Leu (L)  71	  9.3%
Lys (K)  73	  9.5%
Met (M)  20	  2.6%
Phe (F)  33	  4.3%
Pro (P)  39	  5.1%
Ser (S)  64	  8.4%
Thr (T)  45	  5.9%
Trp (W)   6	  0.8%
Tyr (Y)  23	  3.0%
Val (V)  43	  5.6%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 92
Total number of positively charged residues (Arg + Lys): 111

Atomic composition:

Carbon      C	      3831
Hydrogen    H	      6106
Nitrogen    N	      1058
Oxygen      O	      1154
Sulfur      S	        25

Formula: C3831H6106N1058O1154S25
Total number of atoms: 12174

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    67520
Abs 0.1% (=1 g/l)   0.783, assuming all pairs of Cys residues form cystines


Ext. coefficient    67270
Abs 0.1% (=1 g/l)   0.780, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 41.36
This classifies the protein as unstable.



Aliphatic index: 77.81

Grand average of hydropathicity (GRAVY): -0.541