ProtParam
User-provided sequence:
10 20 30 40 50 60
MGQLVDQRIK VGGLNYKSGT SIMIEQLFKN LPVRLKNFVK NSKKEFSKAI NFVINYLIIY
70 80 90 100 110 120
PQIKFTIYNV LNNHKKLILA TKGGDNTTII DNLISIYGNN NNKNLLSLDL EITEDIKLVG
130 140 150 160 170 180
YISSYSFGLG RSAPDRQFLY LNKRPIVFKK LYKLINEIYK SYNHVQYPIY IIDIVINPNL
190 200 210 220 230 240
VDINLLPDKT NVLIKDETTI LQTIETKLSE FFEVQDTMII PKNENYQVKN SEIEIVEKTD
250 260 270 280 290 300
NKNIAVHDDI DTSYKTKINA TRLEGPSEDK DDLNGNDKQE KTGDQDEQEQ ENDDEQQRPE
310 320 330 340 350 360
VDNDVINLSE PVRKTDKDSD NKKVSEIDNN ENVANQISTV NQPSNSQGVL STNEQNEMSE
370 380 390 400 410 420
NIKITTFEPI LESAEPSTIE NKHIILDEPV VLESSQENNN NSIFSSHDIK SSPQNTCTAD
430 440 450 460 470 480
TLEMNKLFCH QEHDEEEDKC DHQDNHGKNF YPVKHKLDDS EEENMTVISI GDETFQQYDE
490 500 510 520 530 540
RRPSKRLKRD MLRNMYNKKI VNSSQDILSS INKNLQSPQN QSESIVIKKE PDEVKPNSVE
550 560 570 580 590 600
DLQTNQQQQY EEVESYQINK QDFLKMKLIG QFNLGFIIVD FDDNNNLFII DQHASDEKYN
610 620 630 640 650 660
FEKLMASFKI NYQLLIKPIK LELSVIDQML VIDNQEIFHN NGFKLKINST PVDNEILLLT
670 680 690 700 710 720
LPIYQNITFN LDDFNELLNL VSQQQDQVNP NLKCSKIKKI LAMKACRSSI MIGTFLSKSK
730 740 750 760 770
MREIISNLST LDKPWNCPHG RPTMRHLIDI KNWQPTSSAS RTSSNGFPST SVDYEL
References and
documentation are available.
Number of amino acids: 776
Molecular weight: 89427.65
Theoretical pI: 5.04
Total number of negatively charged residues (Asp + Glu): 118
Total number of positively charged residues (Arg + Lys): 88
Atomic composition:
Carbon C 3936
Hydrogen H 6265
Nitrogen N 1061
Oxygen O 1269
Sulfur S 21
Formula: C
3936H
6265N
1061O
1269S
21
Total number of atoms: 12552
Extinction coefficients:
Extinction coefficients are in units of M
-1 cm
-1, at 280 nm measured in water.
Ext. coefficient 47135
Abs 0.1% (=1 g/l) 0.527, assuming all pairs of Cys residues form cystines
Ext. coefficient 46760
Abs 0.1% (=1 g/l) 0.523, assuming all Cys residues are reduced
Estimated half-life:
The N-terminal of the sequence considered is M (Met).
The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Instability index:
The instability index (II) is computed to be 45.36
This classifies the protein as unstable.
Aliphatic index: 89.12
Grand average of hydropathicity (GRAVY): -0.673