ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MGSEHYCLRW NNYQSNLLGV FSQLLQDGSL VDVTLVCSEG TSIRAHKVVL SACSSYFQSL 

        70         80         90        100        110        120 
FLEHPEGHLI VILKDVRFAE LQTLVEFMYK GEVNVQYCQL SALLKTAESL KVKGLAEMTN 

       130        140        150        160        170        180 
QNTTLREPER EPDRLRPQGG GGSGGSAHKA ADSPAAALDA TAATQAATAT ATATAAAATS 

       190        200        210        220        230        240 
TSTSATSAAA TAAATAATSA STTATAAAGS SNTTTTTAAT TTATCATAAT STSTAATSSS 

       250        260        270        280        290        300 
SSVTSAAAAA AAAASASGVA HSEEATSSSS STGGQKREAS DRSSPTPAKR SSRMHPADKV 

       310        320        330        340        350        360 
DVAEDREQEQ NQADELLSEE LLGRNLKDEE DDDVDELDEN EETKLRGRDE DDDDEDEEDD 

       370        380        390        400        410        420 
TPMPLDLYQR PNVEPKSAAA ATAAQQGGSN SLSGSSNACH TNSSSNSNNN NNNNNNSSSN 

       430        440        450        460        470        480 
NNNNTSSGKT SASSNGGTAS SGGTADSVVA VDDDDDDDDG GHHHQRQVMD DRLEQDVDEE 

       490        500        510        520        530        540 
DLDDDVVVVG PATAMARGIA QRLAHQNLQR LHHTHHHAQH QHSQHHHPHS QHHHTPHHQQ 

       550        560        570        580        590        600 
HHTHSDDEDA MPVIAKSEIL DDDYDDEMDL EDDDEADNSS NDLGLNMKMG SGGAGGGGGV 

       610        620        630        640        650        660 
DLSTGSTLIP SPLITLPSSS AAAAAAAAAA MESQRSTPAM SAAQAAGAGA SDLSIGGCGG 

       670        680        690        700        710        720 
RPASRSSRDG GGNDGGRGGA SSSSLLSPGT VANLLPVQSV PLSLKKEIDC SEDDNSSHSR 

       730        740        750        760        770        780 
HMQQRSASAG GGLGGDLDYR ASHESETSES PHQQQQPPPH AVGVGAGGGS AAAAAAAAAA 

       790        800        810        820        830        840 
LLHQQQQQQP PHSPPPPPLH MFPCIYCRSA FPNQSKLTRH LLTHSLKTLE YREPTTTALL 

       850        860        870        880        890        900 
HSHLLGDLNM AAAGLPSPFA FQMNAAAMAA TSGSDTQEQV AALAAAFGID MEAALSLAST 

       910        920        930        940        950        960 
GCTFQSLTAS CLEASSGGGS GGGGQGSLSR SATSAGNGGG LMLGSGSGSG SRAAAATGGS 

       970        980        990       1000       1010       1020 
GSSGCGGGGG TATSGSLSPS TSAAAAAAAA AQSQSAALLG AASSDPNSVV MCDRPFKCEF 

      1030       1040       1050       1060       1070       1080 
CGKAFKLRHH MKDHCRVHTG ERPFRCNMCG KTFSRSTILK AHEKTHFPKY VRKFLSPSSP 


VDTKDELPQ 

References and documentation are available.

Number of amino acids: 1089

Molecular weight: 111421.52

Theoretical pI: 5.13

Amino acid composition: 
Ala (A) 162	 14.9%
Arg (R)  41	  3.8%
Asn (N)  43	  3.9%
Asp (D)  74	  6.8%
Cys (C)  19	  1.7%
Gln (Q)  53	  4.9%
Glu (E)  55	  5.1%
Gly (G) 100	  9.2%
His (H)  49	  4.5%
Ile (I)  13	  1.2%
Leu (L)  83	  7.6%
Lys (K)  30	  2.8%
Met (M)  23	  2.1%
Phe (F)  18	  1.7%
Pro (P)  48	  4.4%
Ser (S) 146	 13.4%
Thr (T)  80	  7.3%
Trp (W)   1	  0.1%
Tyr (Y)  11	  1.0%
Val (V)  40	  3.7%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 129
Total number of positively charged residues (Arg + Lys): 71

Atomic composition:

Carbon      C	      4632
Hydrogen    H	      7359
Nitrogen    N	      1437
Oxygen      O	      1681
Sulfur      S	        42

Formula: C4632H7359N1437O1681S42
Total number of atoms: 15151

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    23015
Abs 0.1% (=1 g/l)   0.207, assuming all pairs of Cys residues form cystines


Ext. coefficient    21890
Abs 0.1% (=1 g/l)   0.196, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 50.99
This classifies the protein as unstable.



Aliphatic index: 59.91

Grand average of hydropathicity (GRAVY): -0.528