ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MGVINVQGSP SFSIHSSESN LRKSRALKKP FCSIRNRVYC AQSSSAAVDE SKNITMGDSF 

        70         80         90        100        110        120 
IRPHLRQLAA YQPILPFEVL SAQLGRKPED IVKLDANENP YGPPPEVFEA LGNMKFPYVY 

       130        140        150        160        170        180 
PDPQSRRLRD ALAQDSGLES EYILVGCGAD ELIDLIMRCV LDPGEKIIDC PPTFSMYVFD 

       190        200        210        220        230        240 
AAVNGAGVIK VPRNPDFSLN VDRIAEVVEL EKPKCIFLTS PNNPDGSIIS EDDLLKILEM 

       250        260        270        280        290        300 
PILVVLDEAY IEFSGVESRM KWVKKYENLI VLRTFSKRAG LAGLRVGYGA FPLSIIEYLW 

       310        320        330        340        350        360 
RAKQPYNVSV AGEVAALAAL SNGKYLEDVR DALVRERERL FGLLKEVPFL NPYPSYSNFI 

       370        380        390        400        410 
LCEVTSGMDA KKLKEDLAKM GVMVRHYNSQ ELKGYVRVSA GKPEHTDVLM ECLKQFY 

References and documentation are available.

Number of amino acids: 417

Molecular weight: 46634.85

Theoretical pI: 5.81

Amino acid composition: 
Ala (A)  30	  7.2%
Arg (R)  24	  5.8%
Asn (N)  18	  4.3%
Asp (D)  23	  5.5%
Cys (C)   8	  1.9%
Gln (Q)  10	  2.4%
Glu (E)  31	  7.4%
Gly (G)  25	  6.0%
His (H)   4	  1.0%
Ile (I)  24	  5.8%
Leu (L)  44	 10.6%
Lys (K)  26	  6.2%
Met (M)  11	  2.6%
Phe (F)  17	  4.1%
Pro (P)  28	  6.7%
Ser (S)  33	  7.9%
Thr (T)   6	  1.4%
Trp (W)   2	  0.5%
Tyr (Y)  18	  4.3%
Val (V)  35	  8.4%
Pyl (O)   0	  0.0%
Sec (U)   0	  0.0%

 (B)   0	  0.0%
 (Z)   0	  0.0%
 (X)   0	  0.0%


Total number of negatively charged residues (Asp + Glu): 54
Total number of positively charged residues (Arg + Lys): 50

Atomic composition:

Carbon      C	      2095
Hydrogen    H	      3315
Nitrogen    N	       553
Oxygen      O	       611
Sulfur      S	        19

Formula: C2095H3315N553O611S19
Total number of atoms: 6593

Extinction coefficients:

Extinction coefficients are in units of  M-1 cm-1, at 280 nm measured in water.

Ext. coefficient    38320
Abs 0.1% (=1 g/l)   0.822, assuming all pairs of Cys residues form cystines


Ext. coefficient    37820
Abs 0.1% (=1 g/l)   0.811, assuming all Cys residues are reduced

Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 42.66
This classifies the protein as unstable.



Aliphatic index: 95.13

Grand average of hydropathicity (GRAVY): -0.132