ProtParam
User-provided sequence:
10 20 30 40 50 60
MLETLRGNKL HSGTSKGANK KLNELLESSD NLPSASSELG SIQVSINELR RRVFQLRSKN
70 80 90 100 110 120
KASKDYTKAH YLLANSGLSF EDVDAFIKDL QTNQFLEPNP PKIIESEELE FYIRTKKEEN
130 140 150 160 170 180
ILMSIEQLLN GATKDFDNFI NHNLNLDWAQ HKNEVMKNFG ILIQDKKTVD HKKSISSLDP
190 200 210 220 230 240
KLPSWGNKGN NILNSNESRL NVNENNILRE KFENYARIVF QFNNSRQANG NFDIANEFIS
250 260 270 280 290 300
ILSSANGTRN AQLLESWKIL ESMKSKDINI VEVGKQYLEQ QFLQYTDNLY KKNMNEGLAT
310 320 330 340 350 360
NVNKIKSFID TKLKKADKSW KISNLTVING VPIWALIFYL LRAGLIKEAL QVLVENKANI
370 380 390 400 410 420
KKVEQSFLTY FKAYASSKDH GLPVEYSTKL HTEYNQHIKS SLDGDPYRLA VYKLIGRCDL
430 440 450 460 470 480
SRKNIPAVTL SIEDWLWMHL MLIKEKDAEN DPVYERYSLE DFQNIIISYG PSRFSNYYLQ
490 500 510 520 530 540
TLLLSGLYGL AIDYTYTFSE MDAVHLAIGL ASLKLFKIDS STRLTKKPKR DIRFANILAN
550 560 570 580 590 600
YTKSFRYSDP RVAVEYLVLI TLNEGPTDVE LCHEALRELV LETKEFTVLL GKIGRDGARI
610 620 630 640 650 660
PGVIEERQPL LHVRDEKEFL HTITEQAARR ADEDGRIYDS ILLYQLAEEY DIVITLVNSL
670 680 690 700 710 720
LSDTLSASDL DQPLVGPDDN SETNPVLLAR RMASIYFDNA GISRQIHVKN KEICMLLLNI
730 740 750 760 770 780
SSIRELYFNK QWQETLSQME LLDLLPFSDE LSARKKAQDF SNLDDNIVKN IPNLLIITLS
790 800 810 820 830
CISNMIHILN ESKYQSSTKG QQIDSLKNVA RQCMIYAGMI QYRMPRETYS TLINIDVSL
References and
documentation are available.
Number of amino acids: 839
Molecular weight: 96173.86
Theoretical pI: 6.38
Total number of negatively charged residues (Asp + Glu): 108
Total number of positively charged residues (Arg + Lys): 103
Atomic composition:
Carbon C 4302
Hydrogen H 6848
Nitrogen N 1156
Oxygen O 1298
Sulfur S 20
Formula: C
4302H
6848N
1156O
1298S
20
Total number of atoms: 13624
Extinction coefficients:
Extinction coefficients are in units of M
-1 cm
-1, at 280 nm measured in water.
Ext. coefficient 94910
Abs 0.1% (=1 g/l) 0.987, assuming all pairs of Cys residues form cystines
Ext. coefficient 94660
Abs 0.1% (=1 g/l) 0.984, assuming all Cys residues are reduced
Estimated half-life:
The N-terminal of the sequence considered is M (Met).
The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Instability index:
The instability index (II) is computed to be 45.18
This classifies the protein as unstable.
Aliphatic index: 100.08
Grand average of hydropathicity (GRAVY): -0.365