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ProtParam

User-provided sequence:

        10         20         30         40         50         60 
MLKIKRVPTV VSNYQKDDGA EDPVGCGRNC LGACCLNGAR LPLYACKNLV KSGEKLVISH

70 80 90 100 110 120
EAIEPPVAFL ESLVLGEWED RFQRGLFRYD VTACETKVIP GKYGFVAQLN EGRHLKKRPT

130 140 150 160 170 180
EFRVDKVLQS FDGSKFNFTK VGQEELLFQF EAGEDAQVQF FPCMPIDPEN SPSVVAINVS

190 200 210 220 230 240
PIEYGHVLLI PRVLDCLPQR IDHKSLLLAV HMAAEAANPY FRLGYNSLGA FATINHLHFQ

250 260 270 280 290 300
AYYLAMPFPL EKAPTKKITT TVSGVKISEL LSYPVRSLLF EGGSSMQELS DTVSDCCVCL

310 320 330 340 350 360
QNNNIPFNIL ISDCGRQIFL MPQCYAEKQA LGEVSPEVLE TQVNPAVWEI SGHMVLKRKE

370 380 390 400 410 420
DYEGASEDNA WRLLAEASLS EERFKEVTAL AFEAIGCSNQ EEDLEGTIVH QQNSSGNVNQ

430 440
KSNRTHGGPI TNGTAAECLV LQ


References and documentation are available.

Number of amino acids: 442 Molecular weight: 48969.90 Theoretical pI: 5.29
Amino acid composition: 
Ala (A) 33 7.5% Arg (R) 18 4.1% Asn (N) 23 5.2% Asp (D) 17 3.8% Cys (C) 15 3.4% Gln (Q) 21 4.8% Glu (E) 38 8.6% Gly (G) 30 6.8% His (H) 10 2.3% Ile (I) 20 4.5% Leu (L) 46 10.4% Lys (K) 23 5.2% Met (M) 7 1.6% Phe (F) 21 4.8% Pro (P) 24 5.4% Ser (S) 29 6.6% Thr (T) 17 3.8% Trp (W) 3 0.7% Tyr (Y) 12 2.7% Val (V) 35 7.9% Pyl (O) 0 0.0% Sec (U) 0 0.0% (B) 0 0.0% (Z) 0 0.0% (X) 0 0.0%
Total number of negatively charged residues (Asp + Glu): 55 Total number of positively charged residues (Arg + Lys): 41 Atomic composition: Carbon C 2176 Hydrogen H 3414 Nitrogen N 586 Oxygen O 655 Sulfur S 22 Formula: C2176H3414N586O655S22 Total number of atoms: 6853 Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 35255 Abs 0.1% (=1 g/l) 0.720, assuming all pairs of Cys residues form cystines Ext. coefficient 34380 Abs 0.1% (=1 g/l) 0.702, assuming all Cys residues are reduced Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo). Instability index: The instability index (II) is computed to be 45.14 This classifies the protein as unstable. Aliphatic index: 88.67 Grand average of hydropathicity (GRAVY): -0.163